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Protocadherin alpha subfamily C, 1

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Alpha-1, Protocadherin, Pcdh-alpha, Protocadherins, Inactive
Papers on Pcdh-alphaC1
Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-alpha gene cluster.
Yagi et al., Suita, Japan. In J Biol Chem, 2008
In vivo, the promoter and 5'-regions of the Pcdh-alphaC1 and alphaC2 exons, which are transcribed in all neurons, were extensively hypomethylated.
Identification of long-range regulatory elements in the protocadherin-alpha gene cluster.
Maniatis et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 2007
The two remaining V exons in the cluster (Pcdh-alphaC1 and alphaC2) are expressed biallelically in every neuron.
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