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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Proprotein convertase subtilisin/kexin type 5

PC6, PC5
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: CAN, PC1, PC2, PCS, PACE4
Papers using PC6 antibodies
Analyzing real-time PCR data by the comparative C(T) method
Arumäe U et al., In Cell Death & Disease, 2007
... PC6 cells were grown in DMEM (Invitrogen) containing 10% of horse serum (PAA Laboratories, Pasching, Austria), 5% of fetal bovine serum (HyClone, Thermo Scientific, Loughborough, UK) and 100  ...
Papers on PC6
Short-term complementary and alternative medicine on quality of life in women with fibromyalgia.
Guimarães et al., Fortaleza, Brazil. In J Integr Med, Jan 2016
AC, EAC and MX were delivered for 30 min, once a week, for 8 weeks, bilaterally at Neiguan (PC6), Hegu (LI4), Yanglingquan (GB34), Sanyinjiao (SP6) and Taichong (LR3) acupoints.
Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition.
Lindberg et al., Baltimore, United States. In Bone, Jan 2016
In vitro, PC1/3 and PC2, but not furin, efficiently cleaved glycosylated FGF23; surprisingly, PC5/6 accomplished a small amount of conversion.
Phosphorylation of Fe65 amyloid precursor protein-binding protein in response to neuronal differentiation.
Iverfeldt et al., Stockholm, Sweden. In Neurosci Lett, Jan 2016
Similar effects were observed in rat PC6.3 cells treated with nerve growth factor.
Have First-Year Emergency Medicine Residents Achieved Level 1 on Care-Based Milestones?
Seamon et al., In J Grad Med Educ, Dec 2015
The majority did not achieve Level 1 on faculty assessment of milestones PC-2, PC-3, PC-5a, and PC-6, and on self-assessment of PC-3 and PC-5a.
Nerve growth factor (NGF) and pro-NGF increase low-density lipoprotein (LDL) receptors in neuronal cells partly by different mechanisms: role of LDL in neurite outgrowth.
Lindholm et al., Helsinki, Finland. In J Neurochem, Nov 2015
Here we show that NGF increases LDLR levels in PC6.3 cells and in cultured septal neurons from embryonic rat brain.
Electroacupuncture alleviates cisplatin-induced nausea in rats.
Guo et al., Beijing, China. In Acupunct Med, Oct 2015
EA was performed at CV12 (n=12), bilateral PC6 (n=12), or sham points (n=12) 3 days before and 1-2 days after cisplatin administration (4-5 times in total), at 0.5-1 mA intensity and 2/15 Hz frequency for 10 min.
[Protection of Transcutaneous Acupoint Electrical Stimulation for Brain Injury Undergoing Intervention: a Clinical Observation].
Chen et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Aug 2015
Patients in the EA group were needled at bilateral Neiguan (PC6), Lieque (LU7), and Yunmen (LU2).
[Effect of Acupuncture on Prognosis and Immune Function of Sepsis Patients].
Yang Yan et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Jul 2015
Needling at related points such as Zusanli (ST36), Yanglingquan (GB34), Neiguan (PC6), Guanyuan (RN4), and so on, was performed in patients of the acupuncture treatment group, once per day for 6 successive days.
Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting.
Fan et al., Hong Kong, Hong Kong. In Cochrane Database Syst Rev, 2014
An alternative approach is to stimulate the PC6 acupoint on the wrist.
Tongue acupuncture in treatment of post-stroke dysphagia.
Gao et al., China. In Int J Clin Exp Med, 2014
Acupoits on the body are Fengchi (GB20) and Neiguan (PC6).
The effectiveness of acupuncture in postoperative gastroparesis syndrome--a systematic review and meta-analysis.
Huang et al., Guangzhou, China. In Complement Ther Med, 2014
ST36, CV12 and PC6 seemed to be the common acupoints selected.
The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.
Mbikay et al., Montréal, Canada. In J Biol Chem, 2013
The secretory proprotein convertase (PC) family comprises nine members: PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9.
Immunophenotyping of selected hematologic disorders--focus on lymphoproliferative disorders with more than one malignant cell population.
Porwit, Toronto, Canada. In Int J Lab Hematol, 2013
The B-cell-oriented panel includes the following antibodies: Kappa-FITC/lambda-PE/CD19-ECD/CD38-PC5.5/CD20-PC7/CD34-APC/CD23
The effectiveness of acupuncture in prevention and treatment of postoperative nausea and vomiting--a systematic review and meta-analysis.
Zhang et al., Guangzhou, China. In Plos One, 2012
Meta-analysis showed that PC6 acupuncture significantly reduced the number of cases of early vomiting (postoperative 0-6h) (RR=0.36,
The biology and therapeutic targeting of the proprotein convertases.
Prat et al., Montréal, Canada. In Nat Rev Drug Discov, 2012
Seven of these (proprotein convertase 1 (PC1), PC2, furin, PC4, PC5, paired basic amino acid cleaving enzyme 4 (PACE4) and PC7) activate cellular and pathogenic precursor proteins by cleavage at single or paired basic residues, whereas subtilisin kexin isozyme 1 (SKI-1) and proprotein convertase subtilisin kexin 9 (PCSK9) regulate cholesterol and/or lipid homeostasis via cleavage at non-basic residues or through induced degradation of receptors.
Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions.
Nie et al., Australia. In Endocrinology, 2011
PC6 plays a key role in regulating fundamental cellular remodeling processes, such as plasma membrane transformation and membrane-cytoskeletal interface reorganization.
Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.
Prat et al., Montréal, Canada. In J Mol Med (berl), 2011
Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
Seidah et al., Montréal, Canada. In J Biol Chem, 2011
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.
PCSK5 and GDF11 expression in the hindgut region of mouse embryos with anorectal malformations.
Kubota et al., Kyoto, Japan. In Eur J Pediatr Surg, 2011
PCSK5 and GDF11 expression during hindgut morphogenesis could be key factors for normal anorectal development, which can be disturbed by the administration of an overdose of all-trans retinoic acid, leading to anorectal malformations.
Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin α- and β-subunits as candidate substrates.
Woodruff et al., Chicago, United States. In Plos One, 2010
These data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis.
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