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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Paired box 2

PAX2, pax2.1
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, PAX8, HAD, p27, cytokeratin
Papers using PAX2 antibodies
Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins.
Means Robert E., In PLoS ONE, 2000
... The PAX2 antibodies for westernblot analysis were obtained from Abcam (Cambridge, United Kingdom), for ...
Analysis of relative gene expression data using real time quantitative PCR and the 2-ΔΔct method.
Mattson Mark, In PLoS ONE, 2000
... In a few instances, we used Pax2-GFP transgenic mice to visualize GABAergic ...
Papers on PAX2
Proper Notch activity is necessary for the establishment of proximal cells and differentiation of intermediate, distal, and connecting tubule in Xenopus pronephros development.
Sakurai et al., In Dev Dyn, Feb 2016
Although Notch did not affect the expression of pan-pronephric progenitor marker, pax2, its activation inhibited lumen formation in the pronephros.
The conserved genetic background for pluteus arm development in brittle stars and sea urchin.
Wada et al., Tsukuba, Japan. In Evol Dev, Feb 2016
Several genes are known to be involved in the development of pluteus arms in sea urchins, including fgfA, pax2/5/8, pea3, otp, wnt5, and tet.
Glyphosate induces neurotoxicity in zebrafish.
Ochs et al., Fairfield, United States. In Environ Toxicol Pharmacol, Feb 2016
Concomitant with structural changes in the developing brain, using in situ hybridization analysis, we detect decreases in genes expressed in the eye, fore and midbrain regions of the brain including pax2, pax6, otx2 and ephA4.
How to approach the many faces of endometrioid carcinoma.
Malpica, Houston, United States. In Mod Pathol, Jan 2016
Variants with distinct architectural and cytologic features include the following: (1) ECa with a villoglandular pattern (tumor with finger-like papillae lined by bland cells with a tendency for vascular/lymphatic invasion and lymph node metastasis once this pattern is seen within the myoinvasive component); (2) papillary ECa of intermediate grade (grade 2) (tumor that can be mistaken for serous carcinoma, as it contains papillae showing slightly irregular contours, moderately atypical cells, and it is associated with vascular/lymphatic invasion/lymph node metastasis, but with common association with mucinous metaplasia, MELF (microcystic, elongated, and fragmented) pattern of invasion, and wild p53 expression); (3) ECa with non-villous papillae (tumor containing pseudopapillae within glands with bland-appearing cytology commonly associated with abortive squamous differentiation and otherwise not different from usual ECa); (4) ECa with microglandular-like pattern (tumor that mimics microglandular hyperplasia of the cervix, often lacking the typical appearance of microglandular hyperplasia and showing Ki-67 index >10%, strong CD10 expression, and negative PAX-2, p63, and CD34); and (5) ECa with sex cord-like formations and hyalinization (tumor with interconnected cords and nests of bland epithelioid and spindled cells that merge with a typical component of low-grade ECa, usually associated with squamous differentiation and hyalinization).
Exome Sequencing on 298 Probands With Early-Onset High Myopia: Approximately One-Fourth Show Potential Pathogenic Mutations in RetNet Genes.
Zhang et al., In Invest Ophthalmol Vis Sci, Jan 2016
Of the 71 probands, 44 (62.0%) had mutations in 11 genes responsible for ocular diseases accompanied by high myopia, including COL2A1, COL11A1, PRPH2, FBN1, GNAT1, OPA1, PAX2, GUCY2D, TSPAN12, CACNA1F, and RPGR.
Thyroid-like follicular carcinoma of the kidney: one case report and review of the literature.
Nodit et al., Pittsburgh, United States. In Am J Clin Pathol, Nov 2015
The tumor cells strongly expressed CK7, PAX-8, PAX-2, vimentin, EMA, and CK19 immunostains.
Nephron organoids derived from human pluripotent stem cells model kidney development and injury.
Bonventre et al., Boston, United States. In Nat Biotechnol, Nov 2015
By recapitulating metanephric kidney development in vitro, we generate SIX2(+)SALL1(+)WT1(+)PAX2(+) NPCs with 90% efficiency within 9 days of differentiation.
[Clinicopathologic study of primary renal hemangioblastoma].
Rao et al., Nanjing, China. In Zhonghua Bing Li Xue Za Zhi, Jun 2015
Immunohistochemical study showed that the stromal cells were positive for alpha-inhibin (3/3), S-100 protein (3/3), EGFR (2/2), PAX-2 (2/2), PAX-8 (2/2) and CA9 (2/2) but negative for CKpan (2/2) and HMB45 (2/2).
Renal dysplasia.
Chang et al., Taiwan. In Arch Pathol Lab Med, Apr 2015
Immunohistochemical expression of the paired box genes 2 and 8 (PAX2/8) and Wilms tumor 1 (WT1) is increased in the primitive ducts and fibromuscular collar, respectively.
Metanephric adenofibroma in a 10-year-old boy: report of a case and review of the literature.
Guo et al., Nanjing, China. In Int J Clin Exp Pathol, 2014
Epithelial and stromal elements were both positive for WT-1, Vimentin, PAX2, and the epithelial tumor cells were also positive for S100, AE1/AE3, PAX8, CK8/18, EMA and a few cells were positive for CK7.
Through the glass darkly: intraepithelial neoplasia, top-down differentiation, and the road to ovarian cancer.
Xian et al., Boston, United States. In J Pathol, 2013
Both direct and indirect ('surrogate') precursors suggest that the benign tube undergoes important biological changes after menopause, acquiring abnormalities in gene expression that are often shared with malignancy, including PAX2, ALDH1, LEF1, RCN1, RUNX2, beta-catenin, EZH2, and others.
c-Met and NF-κB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease.
Kreidberg et al., Boston, United States. In J Am Soc Nephrol, 2012
Hyperactivated Wnt signaling increased expression of the transcription factor Pax2 in the cells lining cysts in autosomal dominant polycystic kidney disease.
Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation.
Nechiporuk et al., Portland, United States. In Development, 2012
Pax2a and Pax8 regulate cell differentiation during sensory placode formation
Utility of PAX8 and PAX2 immunohistochemistry in the identification of renal cell carcinoma in diagnostic cytology.
Roh et al., Ann Arbor, United States. In Diagn Cytopathol, 2012
PAX8 and PAX2 are diagnostically useful adjuncts in confirming the diagnosis of renal cell carcinoma in cytology specimens.
PAX2 is an antiapoptotic molecule with deregulated expression in medulloblastoma.
Steinbach et al., Frankfurt am Main, Germany. In Int J Oncol, 2012
PAX2 expression was detected in the majority of medulloblastoma samples and correlated with less differentiated histology
Biomarkers of progestin therapy resistance and endometrial hyperplasia progression.
Garcia et al., Seattle, United States. In Am J Obstet Gynecol, 2012
No association was found between Pax-2 expression and disease persistance/progression in endometrial hyperplasia treated with progestins.
Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Carroll et al., Cambridge, United Kingdom. In Nature, 2009
We implicate the paired box 2 gene product (PAX2), in a previously unrecognized role, as a crucial mediator of ER repression of ERBB2 by the anti-cancer drug tamoxifen.
Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis.
Shang, Beijing, China. In Nat Rev Cancer, 2006
Ultimately, oestrogen and SERMs affect the transduction of cellular signalling pathways that govern cell growth and proliferation, through downstream effectors such as PAX2 (paired box 2).
Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis.
Shang et al., Beijing, China. In Nature, 2006
Among the overlapping target genes, we identify a paired-box gene, PAX2, that is crucially involved in cell proliferation and carcinogenesis in the endometrium.
Derivation of nephrogenic adenomas from renal tubular cells in kidney-transplant recipients.
Susani et al., Vienna, Austria. In N Engl J Med, 2002
The presence of aquaporin 1, PAX2, and lectin-binding capacity for peanut agglutinin, Lotus tetragonolobus agglutinin, and Sophora japonica agglutinin in nephrogenic adenomas indicated an origin from renal tubular cells.
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