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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


PATJ, PDZ domain protein, CIPP
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Stardust, MUPP1, CAN, PSD-95, V1a
Papers on PATJ
Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics.
Rao et al., Edinburgh, United Kingdom. In Am J Physiol Cell Physiol, Feb 2016
Periaxin (Prx), a PDZ domain protein expressed preferentially in myelinating Schwann cells and lens fibers, plays a key role in membrane scaffolding and cytoarchitecture.
Glutamate receptor interacting protein 1 regulates CD4(+) CTLA-4 expression and transplant rejection.
Morrell et al., Rochester, United States. In Am J Transplant, Dec 2015
Glutamate receptor interacting protein 1 (GRIP1), a 7 PDZ domain protein scaffold regulates glutamate receptor surface expression and trafficking in neurons.
Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry.
Kreek et al., New York City, United States. In Cns Neurosci Ther, Nov 2015
SNP rs3915568 in NTSR1, which encodes neurotensin receptor, and SNP rs1389752 in MPDZ, which encodes the multiple PDZ domain protein, were previously associated with heroin addiction or alcohol addiction, respectively.
Biochemical Large-Scale Interaction Analysis of Murine Olfactory Receptors and Associated Signaling Proteins with Post-Synaptic Density 95, Drosophila Discs Large, Zona-Occludens 1 (PDZ) Domains.
Osterloh et al., Bochum, Germany. In Mol Cell Proteomics, Aug 2015
This system includes the 13 individual PDZ domains of the multiple PDZ domain protein 1 (MUPP1; the largest PDZ protein), a broad range of murine olfactory receptors (a multifaceted gene cluster within the family of GPCRs), and associated olfactory signaling proteins.
PDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target Proteins.
Banerjee et al., Stillwater, United States. In Biology (basel), 2014
Human Tax-interacting protein 1 (TIP-1), also known as glutaminase interaction protein (GIP), is a Class I PDZ domain protein that recognizes the consensus binding motif X-S/T-X-V/I/L-COOH of the C-terminus of its target proteins.
Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules.
Hague et al., Seattle, United States. In Cell Discov, 2014
Unexpectedly, a second PDZ domain protein, scribble (SCRIB), was detected in ADRA1D complexes.
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.
Xu et al., Los Angeles, United States. In Nat Med, 2013
Sorting nexin 27 (SNX27), a brain-enriched PDZ domain protein, regulates endocytic sorting and trafficking.
Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability.
Hong et al., Pittsburgh, United States. In Development, 2012
dPatj possesses an as yet unidentified function that is essential for pupal development.
The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival.
Tepass, Toronto, Canada. In Annu Rev Cell Dev Biol, 2011
APRs compose a diverse set of molecules including a transmembrane protein (Crumbs), a serine/threonine kinase (aPKC), a lipid phosphatase (PTEN), a small GTPase (Cdc42), FERM domain proteins (Moesin, Yurt), and several adaptor or scaffolding proteins (Bazooka/Par3, Par6, Stardust, Patj).
Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models.
Buck et al., Portland, United States. In Alcohol Clin Exp Res, 2011
Analyses of neuronal activation associated with alcohol withdrawal and site-directed lesions in mice implicate the rostroventral caudate putamen, a ventrolateral segment of the DMS, in genetically determined differences in risk for alcohol withdrawal involved in physical association of the multi-PDZ domain protein, MPDZ, with 5-HT(2C) receptors and/or NR2B.
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions.
Kissil et al., Philadelphia, United States. In Cancer Cell, 2011
We have identified a tight-junction-associated protein complex comprising Merlin, Angiomotin, Patj, and Pals1.
Protein complexes that control renal epithelial polarity.
Margolis et al., Ann Arbor, United States. In Am J Physiol Renal Physiol, 2011
The apical Crumbs complex consists of three proteins, Crumbs, PALS1, and PATJ, whereas the apical Par complex consists of Par-3, Par-6, and atypical protein kinase C. The lateral Scribble complex consists of Scribble, discs large, and lethal giant larvae.
The paradox of dopamine and angiotensin II-mediated Na(+), K(+)-ATPase regulation in renal proximal tubules.
Wang et al., China. In Clin Exp Hypertens, 2009
The antagonistic actions were mediated by the phosphorylation of different position of NKA α₁-subunit and different Pals-associated tight junction protein (PATJ) PDZ domains, the different protein kinase C (PKC) isoforms (PKC-β, PKC-ζ), the common adenylyl cyclase (AC) pathway, and the crosstalk and balance between DA and Ang II to NKA regulation.
Pals-associated tight junction protein functionally links dopamine and angiotensin II to the regulation of sodium transport in renal epithelial cells.
Bertorello et al., Stockholm, Sweden. In Br J Pharmacol, 2009
Signalling molecules and effectors can be integrated into a functional network by the scaffold organizer protein PATJ via its multiple PDZ domains.
Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins.
Tsukita et al., Kyoto, Japan. In Mol Cell Biol, 2009
Results suggest that signaling mediated by Pals1, which has a higher affinity for Patj than for MUPP1 and is involved in the activation of the Par6-aPKC complex, is of principal importance for the function of Patj in epithelial cells.
Channel-interacting PDZ protein, 'CIPP', interacts with proteins involved in cytoskeletal dynamics.
Dente et al., Pisa, Italy. In Biochem J, 2009
Data show taht channel-interacting PDZ protein, 'CIPP', interacts with proteins involved in cytoskeletal dynamics, in particular, with the small G-protein effector IRSp53
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.
Holmgren et al., Stockholm, Sweden. In Blood, 2009
the directional migration of capillaries in the embryo is governed by the Amot:Patj/Mupp1:Syx signaling that controls local GTPase activity
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization.
Knoblich et al., Vienna, Austria. In Cell, 2008
Phosphorylated Lgl is released from aPKC and thereby allows the PDZ domain protein Bazooka to enter the complex.
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.
Pawson et al., Toronto, Canada. In Cell, 2006
Rich1 binds the scaffolding protein angiomotin (Amot) and is thereby targeted to a protein complex at tight junctions (TJs) containing the PDZ-domain proteins Pals1, Patj, and Par-3.
A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.
Adams et al., Baltimore, United States. In Nat Genet, 2004
Cell adhesion to extracellular matrix (ECM) proteins is crucial for the structural integrity of tissues and epithelial-mesenchymal interactions mediating organ morphogenesis.
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