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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Chromosome 9 open reading frame 86

ParF, partner of ARF, Rab-like protein 1, RBEL1
This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: PARG, V1a, p16, p53, mdm2
Papers on ParF
RBEL1 is required for osteosarcoma cell proliferation via inhibiting retinoblastoma 1.
Yue et al., Nanjing, China. In Mol Med Report, Jan 2016
The present study shows that RBEL1, a newly identified Rab‑like GTPase, may be a key regulator of osteosarcoma cell proliferation.
CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis.
Wadhwa et al., Tsukuba, Japan. In Mol Oncol, Nov 2015
Collaborator of ARF (CARF), initially identified as a binding partner of ARF (Alternate Reading Frame), has been shown to activate ARF-p53 pathway by multiple ways including stabilization of ARF and p53 tumor suppressor proteins, and transcriptional repression of a p53 antagonist, HDM2.
Bioinformatics analysis of transcriptional regulation of circadian genes in rat liver.
Androulakis et al., United States. In Bmc Bioinformatics, 2013
With the assumption that transcription factors (TFs) that are differentially expressed and contain CLOCK:BMAL1 binding sites on their proximal promoters are likely to be clock-controlled TFs, we were able to use promoter analysis to putatively identify additional clock-controlled TFs besides PARF and RORA families.
Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics.
Hayes et al., Manchester, United Kingdom. In J Biol Chem, 2013
Here, we establish that hyperactive ATPase variants of the ParA homolog ParF display altered segrosome dynamics that block accurate DNA segregation.
Structural mechanism of ATP-induced polymerization of the partition factor ParF: implications for DNA segregation.
Hayes et al., Durham, United States. In J Biol Chem, 2012
Segregation of the bacterial multidrug resistance plasmid TP228 requires the centromere-binding protein ParG, the parH centromere, and the Walker box ATPase ParF.
Region specific and worldwide distribution of collagen-binding M proteins with PARF motifs among human pathogenic streptococcal isolates.
Nitsche-Schmitz et al., Braunschweig, Germany. In Plos One, 2011
Moreover, their potential to trigger collagen autoimmunity has been implicated in the pathogenesis of acute rheumatic fever and attributed to a collagen-binding motif called PARF (peptide associated with rheumatic fever).
Segrosome assembly at the pliable parH centromere.
Hayes et al., Manchester, United Kingdom. In Nucleic Acids Res, 2011
The segrosome of multiresistance plasmid TP228 comprises ParF, which is a member of the ParA ATPase superfamily, and the ParG ribbon-helix-helix factor that assemble jointly on the parH centromere.
Identification of active variants of PARF in human pathogenic group C and group G streptococci leads to an amended description of its consensus motif.
Chhatwal et al., Braunschweig, Germany. In Int J Med Microbiol, 2009
Therefore, the octapeptide motif was named peptide associated with rheumatic fever (PARF).
Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation.
Huang et al., Syracuse, United States. In J Biol Chem, 2009
characterization of all four RBEL1 splice variants in terms of their GTPase activities, subcellular localizations, regulations & potential functions; results indicate RBEL1 proteins are linked to cell growth & survival & possess unique characteristics
CARF: an emerging regulator of p53 tumor suppressor and senescence pathway.
Wadhwa et al., Tsukuba, Japan. In Mech Ageing Dev, 2009
CARF was first discovered as a binding partner of ARF and has since been shown to have both ARF-dependent and -independent functions that converge to regulate p53 pathway.
Crucial role of the CB3-region of collagen IV in PARF-induced acute rheumatic fever.
Chhatwal et al., Braunschweig, Germany. In Plos One, 2008
Because of its role in the induction of disease-related collagen autoimmunity the motif is referred to as "peptide associated with rheumatic fever" (PARF).
RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer.
Huang et al., Syracuse, United States. In J Biol Chem, 2008
RBEL1A and RBEL1B are novel Rab-like proteins that localize in the nucleus and cytosol and may play an important role in breast tumorigenesis
Promiscuous stimulation of ParF protein polymerization by heterogeneous centromere binding factors.
Hayes et al., Manchester, United Kingdom. In J Mol Biol, 2007
The segrosome of plasmid TP228 comprises ParF and ParG proteins that assemble on the parH centromere.
The tail of the ParG DNA segregation protein remodels ParF polymers and enhances ATP hydrolysis via an arginine finger-like motif.
Hayes et al., York, United Kingdom. In Proc Natl Acad Sci U S A, 2007
The ParF protein of plasmid TP228 belongs to the ubiquitous superfamily of ParA ATPases that drive DNA segregation in bacteria.
CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints.
Wadhwa et al., Tsukuba, Japan. In Ann N Y Acad Sci, 2006
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen.
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