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Parathyroid hormone

Parathyroid Hormone, PTH
The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, fibrillin-1, FGF23
Papers using Parathyroid Hormone antibodies
Pseudohypoparathyroidism and GNAS epigenetic defects: clinical evaluation of Albright hereditary osteodystrophy and molecular analysis in 40 patients
Friedman Peter A et al., In Journal of Bone and Mineral Research, 2009
... Human PTH(1–34) and PTH(7–34) were obtained from Bachem (Torrance, CA, USA) ...
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum
Lane Nancy E et al., In Journal of Bone and Mineral Research, 2007
... = 10 to 11) or 40 µg/kg human PTH(1-34) (n = 12) (Bachem Bioscience, Inc., Torrance, CA, ...
Effect of surrounding tissue on density evaluation via microcomputed tomography
Ito K. et al., In Osteoporosis International, 2006
... Synthetic human PTH (1–34; Bachem, Bubendorf, Switzerland) was dissolved ...
Cotreatment of parathyroid hormone with osteoprotegerin or alendronate increases its anabolic effect on the skeleton of oophorectomized mice
Manolagas Stavros C et al., In Journal of Bone and Mineral Research, 2006
... mice were infused for 5 days with 0.001% β-mercaptoethanol, 0.06% acetic acid (PTH vehicle), 470 ng/h PTH(1-84) (Bachem, Torrance, CA, USA), or ...
Low IGF-I in synovial fluid and serum in patients with aseptic prosthesis loosening
Lerner Ulf H et al., In Arthritis Research & Therapy, 2004
... Synthetic bovine parathyroid hormone [PTH-(1–34)] was obtained from Bachem AG (Bubendorf, Switzerland); recombinant ...
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Papers on Parathyroid Hormone
The effects of combined human parathyroid hormone (1-34) and simvastatin treatment on the interface of hydroxyapatite-coated titanium rods implanted into osteopenic rats femurs.
Yang et al., Wenzhou, China. In J Mater Sci Mater Med, Mar 2016
The effect of human parathyroid hormone 1-34 (PTH) and simvastatin (SIM) alone could promote bone healing in osteoporotic implant fixation, but there are no reports about the combined use of PTH and SIM for promotion of bone healing around implant in osteoporotic settings.
Epidemiology and determinants of pruritus in pre-dialysis chronic kidney disease patients.
Erdem et al., Sakarya, Turkey. In Int Urol Nephrol, Feb 2016
25 (OH) Vitamin D, urea, creatinine, uric acid, calcium, phosphorus, intact parathyroid hormone (PTH), magnesium, albumin, C-reactive protein (CRP), complete blood count and differential and other laboratory tests were studied for each participant.
The effects of cinacalcet treatment on bone mineral metabolism, anemia parameters, left ventricular mass index and parathyroid gland volume in hemodialysis patients with severe secondary hyperparathyroidism.
Ozelsancak et al., Adana, Turkey. In Saudi J Kidney Dis Transpl, Jan 2016
The indication to start calcimimetic therapy was persistent serum levels of parathyroid hormone (PTH) >1000 pg/mL, refractory to intravenous (i.v.) vitamin D and phosphate-binding therapy.
Effects of a Combination Therapy of Sclerostin Antibody III and Raloxifene on Bone Formation Markers in Ovariectomized Rats.
Gad Allam, Riyadh, Saudi Arabia. In J Coll Physicians Surg Pak, Jan 2016
At the end of treatment, serum levels of Bone Specific Alkaline Phosphatase (BSAP), alkaline phosphatase, osteocalcin, Insulin-like Growth Factor-1 (IGF-1), Parathyroid Hormone (PTH), Ca2+ and phosphorus were measured.
On the evolution of the pulmonary alveolar lipofibroblast.
Rehan et al., Torrance, United States. In Exp Cell Res, Jan 2016
Namely, Parathyroid Hormone-related Protein (PTHrP) signaling, expression of Adipocyte Differentiation Related Protein, leptin, peroxisome proliferator activator receptor gamma, and the prostaglandin E2 receptor EP2- which are all stretch-regulated, explaining how and why surfactant production is 'on-demand' in service to ventilation-perfusion matching.
Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism.
Chang et al., San Francisco, United States. In Semin Cell Dev Biol, Jan 2016
UNASSIGNED: Parathyroid hormone (PTH)-related peptide (PTHrP) controls the pace of pre- and post-natal growth plate development by activating the PTH1R in chondrocytes, while PTH maintains mineral and skeletal homeostasis by modulating calciotropic activities in kidneys, gut, and bone.
T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone.
Pacifici, Atlanta, United States. In Ann N Y Acad Sci, Jan 2016
In addition, T cells regulate the differentiation and life span of stromal cells (SCs) and their responsiveness to parathyroid hormone (PTH) via costimulatory molecules expressed on their surface.
GENETICS IN ENDOCRINOLOGY: Gain and Loss of Function Mutations of the Calcium Sensing Receptor and Associated Proteins: Current Treatment Concepts.
Schöfl et al., Erlangen, Germany. In Eur J Endocrinol, Jan 2016
Therapeutic concepts for these rare diseases range from general therapies of hyper- and hypocalcemic conditions to more pathophysiology oriented approaches such as PTH substitution and allosteric CASR modulators.
PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.
Spiegelman et al., Boston, United States. In Cell Metab, Jan 2016
Here, we show that PTH is involved in stimulating a thermogenic gene program in 5/6 nephrectomized mice that suffer from cachexia.
Heterochrony as Diachronically Modified Cell-Cell Interactions.
Torday, Los Angeles, United States. In Biology (basel), Dec 2015
These tissue-specific remodeling events occurred as a result of the duplication of the Parathyroid Hormone-related Protein Receptor (PTHrPR) gene, expressed in mesodermal fibroblasts in close proximity to ubiquitously expressed endodermal PTHrP, amplifying this signaling pathway.
IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice.
Pacifici et al., Atlanta, United States. In Cell Metab, Dec 2015
Primary hyperparathyroidism (PHPT) is a common cause of bone loss that is modeled by continuous PTH (cPTH) infusion.
International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.
Vilardaga et al., Pittsburgh, United States. In Pharmacol Rev, 2014
The type-1 parathyroid hormone receptor (PTHR1) is a family B G protein-coupled receptor (GPCR) that mediates the actions of two polypeptide ligands; parathyroid hormone (PTH), an endocrine hormone that regulates the levels of calcium and inorganic phosphate in the blood by acting on bone and kidney, and PTH-related protein (PTHrP), a paracrine-factor that regulates cell differentiation and proliferation programs in developing bone and other tissues.
Bone development and mineral homeostasis in the fetus and neonate: roles of the calciotropic and phosphotropic hormones.
Kovacs, St. John's, Canada. In Physiol Rev, 2014
Parathyroid hormone (PTH) and calcitriol circulate at low concentrations in the fetal circulation.
Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.
Spiegelman et al., Boston, United States. In Nature, 2014
Here, using a Lewis lung carcinoma model of cancer cachexia, we show that tumour-derived parathyroid-hormone-related protein (PTHrP) has an important role in wasting, through driving the expression of genes involved in thermogenesis in adipose tissues.
Bone-specific alkaline phosphatase concentrations are less variable than those of parathyroid hormone in stable hemodialysis patients.
Lamb et al., Canterbury, United Kingdom. In Kidney Int, 2012
Biological variation of bone ALP is less than half that reported for PTH, supporting the use of bone ALP as an alternative marker of bone mineral metabolism in the setting of chronic kidney disease-mineral and bone disorder.
Temporal trends and determinants of longitudinal change in 25-hydroxyvitamin D and parathyroid hormone levels.
CaMos Research Group et al., Montréal, Canada. In J Bone Miner Res, 2012
Secular increases in supplemental vitamin D intake influenced both changes in serum 25-hydroxyvitamin D and PTH levels.
Association of intact parathyroid hormone levels with subsequent hip BMD loss: the Osteoporotic Fractures in Men (MrOS) Study.
Orwoll et al., Birmingham, United States. In J Clin Endocrinol Metab, 2012
Older men with higher iPTH levels had approximately a 2-fold greater rate of bone mineral density loss compared with men with lower iPTH levels, irrespective of estimated glomerular filtration rate and 25(OH)D.
Relationship between disease activity and serum levels of vitamin D and parathyroid hormone in rheumatoid arthritis.
Ghorbani et al., Semnān, Iran. In Endocr Regul, 2012
Serum level of vitamin D was inversely related to rheumatoid arthritis activity and this relationship might be independent of PTH secretion or activity.
Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice.
Lanske et al., Boston, United States. In Plos Genet, 2011
our results demonstrate for the first time that PTH directly impacts the mineralization disorders and skeletal deformities of Kl(-/-), but not of Fgf23(-/-) mice, possibly by regulating Opn expression
Phosphate and FGF-23.
Jüppner, Boston, United States. In Kidney Int, 2011
In humans and animals with CKD, elevated FGF-23 levels increase fractional phosphate excretion, reduce serum phosphate levels, and reduce 1α-hydroxylase activity, which reduces 1,25(OH)2D3 formation thereby increasing parathyroid hormone (PTH) secretion.
More papers using Parathyroid Hormone antibodies
Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings
Morreale de Escobar G. et al., In Cerebral Cortex (New York, NY), 2003
... the day of thyroidectomy until delivery (at P0), they were infused with rat 1–84 parathormone (PTH H3086; Bachem GmbH, Weil am Rhein, ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Calbet Jose, In PLoS ONE, 2000
... Human PTH(1–34) (Bachem) was dissolved in HBSS+0.1% ...
Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP
Taylor Colin W. et al., In The Journal of Cell Biology, 1995
... Human PTH fragments were obtained from Bachem; unless specifically stated, “PTH” ...
Factors affecting callus distraction in limb lengthening
Hvid Ivan et al., In Acta Orthopaedica, 1992
... The animals in the first group (PTH) received a subcutaneous injection of 25 µg/kg PTH (human PTH(1–34) (Bachem, Bubendorf, Switzerland) dissolved in ...
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