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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Jumping translocation breakpoint

PAR protein, JTB
Top mentioned proteins: Plasminogen, Par6, CAN, PAR-2, Actin
Papers on PAR protein
Protein cold adaptation: Role of physico-chemical parameters in adaptation of proteins to low temperatures.
Jahandideh et al., Tehrān, Iran. In J Theor Biol, Nov 2015
During years 2007 and 2008, we published three papers (Jahandideh, 2007a, JTB, 246, 159-166; Jahandideh, 2007b, JTB, 248, 721-726; Jahandideh, 2008, JTB, 255, 113-118) investigating sequence and structural parameters in adaptation of proteins to low temperatures.
An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity.
Nance et al., New York City, United States. In Nat Cell Biol, Jun 2015
In Caenorhabditis elegans, contacts polarize early embryonic cells by recruiting the RhoGAP PAC-1 to the adjacent cortex, inducing PAR protein asymmetry.
Protein abundance may regulate sensitivity to external cues in polarized cells.
Dawes et al., Columbus, United States. In J R Soc Interface, Jun 2015
A key player in this process is the Par protein family whose asymmetric localization to anterior and posterior parts of the cell is crucial for proper division and cell fate specification.
CDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryo.
Labbé et al., Montréal, Canada. In Plos One, 2014
Depletion of any PAR protein causes a loss of polarity and embryonic lethality.
Radiosensitization of Pancreatic Cancer Cells In Vitro and In Vivo through Poly (ADP-ribose) Polymerase Inhibition with ABT-888.
Herman et al., Baltimore, United States. In Transl Oncol, 2014
ABT-888 inhibited PAR protein polymerization resulting in dose-dependent feedback up-regulation of PARP and p-ATM suggesting increased DNA damage.
miR-219 regulates neural precursor differentiation by direct inhibition of apical par polarity proteins.
Appel et al., Aurora, United States. In Dev Cell, 2013
This correlates with Par protein disappearance, but mechanisms that cause downregulation are unknown.
Cortical geometry may influence placement of interface between Par protein domains in early Caenorhabditis elegans embryos.
Iron et al., Columbus, United States. In J Theor Biol, 2013
elegans) polarize shortly after fertilization, creating distinct regions of Par protein family members.
Expression and activity of PARP family members in the hippocampus during systemic inflammation: their role in the regulation of prooxidative genes.
Strosznajder et al., Warsaw, Poland. In Neurochem Int, 2013
A higher level of PAR and PARP/PAR protein interaction may affect the functioning of several transcription factors.
[Par polarity complex in mammalian neurogenesis].
Chen et al., Hangzhou, China. In Yi Chuan, 2013
Par polarity complex is the most investigated Par protein among these polarity proteins.
The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold.
Lingel et al., San Francisco, United States. In J Mol Biol, 2012
The JTB structure has a distant relationship to the midkine/pleiotrophin fold, particularly in the conservation of distinctive disulfide bridge patterns.
PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.
Platica et al., United States. In Int J Oncol, 2011
Due to its involvement in cell cycle and its overexpression in several human cancers PAR could represent an attractive target for therapeutic intervention.
Elaborating polarity: PAR proteins and the cytoskeleton.
Zallen et al., New York City, United States. In Development, 2011
Here, we review recent findings on the role of PAR proteins in cell polarity in C. elegans and Drosophila, and emphasize the links that exist between PAR networks and cytoskeletal proteins that both regulate PAR protein localization and act as downstream effectors to elaborate polarity within the cell.
Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma.
Guan et al., Hong Kong, Hong Kong. In Acta Pharmacol Sin, 2010
Our research group and others, focused on the identification and characterization of 1q21 target genes such as JTB, CKS1B, and CHD1L in HCC progression.
Interacting with HBsAg compromises resistance of jumping translocation breakpoint protein to ultraviolet radiation-induced apoptosis in 293FT cells.
Ren et al., Xiamen, China. In Cancer Lett, 2009
Overexpression of JTB conferred resistance to apoptosis induced by ultraviolet radiation
Structural biology of plasmid partition: uncovering the molecular mechanisms of DNA segregation.
Schumacher, Houston, United States. In Biochem J, 2008
Thus, in the present review, the known Par protein and Par-protein complex structures are discussed with regard to their functions in DNA segregation in an attempt to begin to define, at a detailed atomic level, the molecular mechanisms involved in plasmid segregation.
Asymmetric cell divisions in the early embryo of the leech Helobdella robusta.
Weisblat, Berkeley, United States. In Prog Mol Subcell Biol, 2006
Finally, we propose a model in which the unequal second cleavage in Helobdella may be regulated by the polarized distribution of PAR protein homologs, convergent with the unequal first cleavage of the nematode Caenorhabditis elegans (super-phylum Ecdysozoa).
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Kaibuchi et al., Nagoya, Japan. In Nat Cell Biol, 2005
However, little is known about the downstream signals of the Cdc42-PAR protein complex.
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.
Knoblich et al., Vienna, Austria. In Nature, 2003
In Drosophila neuroblasts, the Par protein complex localizes apically and directs localization of the cell fate determinants Prospero and Numb and the adaptor proteins Miranda and Pon to the basal cell cortex, to ensure their segregation into the basal daughter cell.
Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression.
Johnson et al., Hong Kong, Hong Kong. In J Hepatol, 2003
Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and COPA in the tumors than the paired adjacent non-malignant liver tissues.
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