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Acyl-Coenzyme A binding domain containing 3

PAP7, ACBD3, GCP60, acyl-coenzyme A binding domain containing 3
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, ACID, STEP, CAN, mPGES-2
Papers on PAP7
Towards understanding peroxisomal phosphoregulation in Arabidopsis thaliana.
Lillo et al., Stavanger, Norway. In Planta, Jan 2016
A putative protein phosphatase, purple acid phosphatase 7 (PAP7), was found to be dually targeted to ER and peroxisomes and experiments indicated a possible trafficking to peroxisomes via the ER depending on peroxisomal PTS1.
Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes.
Kuypers et al., Oakland, United States. In J Lipid Res, Oct 2015
In contrast to ACBD1 and ACBD3, ligand binding did not result in the dimerization of ACBD6.
Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.
Kim et al., Philadelphia, United States. In Biochem J, Aug 2015
In the present study, we showed that overexpressed acyl-CoA-binding domain containing 3 (ACBD3), a Golgi-bound protein, significantly reduced cellular NAD(+) content via enhancing PARP1's polymerase activity and enhancing auto-modification of the enzyme in a DNA damage-independent manner.
New route for the activation of poly(ADP-ribose) polymerase-1: a passage that links poly(ADP-ribose) polymerase-1 to lipotoxicity?
Csóka et al., Newark, United States. In Biochem J, Aug 2015
In this issue of Biochemical Journal, Chen and colleagues characterize an interaction between ACBD3 (acyl-CoA-binding domain-containing 3) protein and PARP [poly(ADP-ribose) polymerase]-1 through the activation of ERKs (extracellular-signal-regulated kinases).
Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment.
Bogan et al., New Haven, United States. In J Biol Chem, Mar 2015
The TUG C-terminal peptide bound the Golgin-160-associated protein, ACBD3 (acyl-CoA-binding domain-containing 3), and acetylation reduced binding of TUG to ACBD3 but not to Golgin-160.
GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins.
van der Schaar et al., Utrecht, Netherlands. In J Virol, Feb 2015
PI4KIIIβ recruitment to Golgi membranes relies on GBF1/Arf and ACBD3.
Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner.
Zhang et al., Beijing, China. In Antiviral Res, 2014
In this study, we found that NS5A and PI4KB competed for association of acyl-coenzyme A binding domain containing protein 3 (ACBD3), which inhibited HCV replication.
A complex comprising phosphatidylinositol 4-kinase IIIβ, ACBD3, and Aichi virus proteins enhances phosphatidylinositol 4-phosphate synthesis and is critical for formation of the viral replication complex.
Taniguchi et al., Japan. In J Virol, 2014
We previously showed that nonstructural proteins 2B, 2BC, 2C, 3A, and 3AB of Aichi virus (AiV), a picornavirus, interact with the Golgi protein, acyl-coenzyme A binding domain containing 3 (ACBD3), which interacts with PI4KB.
Recruitment of PI4KIIIβ to coxsackievirus B3 replication organelles is independent of ACBD3, GBF1, and Arf1.
van Kuppeveld et al., Utrecht, Netherlands. In J Virol, 2014
Recently, it was shown that kobuviruses recruit PI4KIIIβ through interaction with ACBD3 (acyl coenzyme A [acyl-CoA]-binding protein domain 3), a novel interaction partner of PI4KIIIβ.
The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication.
Neyts et al., Leuven, Belgium. In Biochem Pharmacol, 2013
Two recruitment strategies were reported: (i) binding and modulation of GBF1/Arf1 to enhance recruitment of PI4KIIIβ and (ii) interaction with ACBD3 for recruitment of PI4KIIIβ.
Role of mitochondria in steroidogenesis.
Miller et al., Montréal, Canada. In Best Pract Res Clin Endocrinol Metab, 2012
The components of the transduceosome include the 18 kDa translocator protein (TSPO), the voltage-dependent anion channel (VDAC-1), TSPO-associated protein 7 (PAP7, ACBD3 for acyl-CoA-binding-domain 3), and protein kinase A regulatory subunit 1α (PKAR1A).
DMT1 (IRE) expression in intestinal and erythroid cells is regulated by peripheral benzodiazepine receptor-associated protein 7.
Glass et al., Shreveport, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
The data were consistent with PAP7 interacting with DMT1 and regulating DMT1 expression in K562 cells by modulating expression of DMT1 protein.
The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIβ.
Derisi et al., San Francisco, United States. In J Virol, 2012
The 3A protein of picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta.
ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.
Taniguchi et al., Japan. In Embo J, 2012
results indicate that a viral protein/ACBD3/PI4KB complex is formed to synthesize PI4P at the AiV RNA replication sites and plays an essential role in viral RNA replication
Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): an emerging signaling molecule.
Papadopoulos et al., Montréal, Canada. In Prog Lipid Res, 2010
ACBD3 protein was previously known as peripheral-type benzodiazepine receptor and cAMP-dependent protein kinase associated protein 7 (PAP7), Golgi complex-associated protein of 60kDa (GCP60), Golgi complex-associated protein 1 (GOCAP1), and Golgi phosphoprotein 1 (GOLPH1).
Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states.
Papadopoulos et al., Montréal, Canada. In Biochim Biophys Acta, 2009
Through the assistance of proteins such as the cAMP-dependent protein kinase regulatory subunit Ialpha (PKA-RIalpha) and the PKA-RIalpha- and TSPO-associated acyl-coenzyme A binding domain containing 3 (ACBD3) protein, PAP7, cholesterol is transferred to and docked at the outer mitochondrial membrane.
Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160.
Machamer et al., Baltimore, United States. In J Biol Chem, 2007
nuclear translocation of golgin-160-(140-311) is a highly coordinated event regulated not only by cleavage of the golgin-160 head but also by the oxidation state of GCP60
The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis.
Zhong et al., New Haven, United States. In Cell, 2007
Study reports that ACBD3 is a Numb partner in cell-fate specification, ACBD3 and Numb proteins interact through an essential Numb domain, and the respective loss- and gain-of-function mutant mice share phenotypic similarities.
Is there a mitochondrial signaling complex facilitating cholesterol import?
Culty et al., Washington, D.C., United States. In Mol Cell Endocrinol, 2007
This complex might include proteins such as the mitochondrial voltage-dependent anion channel, the translocator protein-associated protein PAP7 which also functions as an A kinase anchor protein that binds and brings into the complex the regulatory subunit Ialpha of the cAMP-dependent protein kinase.
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