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Phosphoribosyl pyrophosphate synthetase-associated protein 1

PAP39, PRPP synthetase-associated protein, PRPSAP1
binds catalytic subunits of the ribose-phosphate diphosphokinase enzyme complex; may act as a negative regulator of enzyme activity [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, 41-kDa, OUT, PAP, fibrillin-1
Papers on PAP39
Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.
Minchenko et al., In Ukr Biochem J, 2014
It was shown that hypoxia decreases the expression of PRPS1 and PRPS2 genes in both types of glioma cells, being more pronounced in cells without ERN1 function, but PRPSAP1 and PRPSAP2 gene expressions are suppressed by hypoxia only in glioma cells with blockade of ERN1.
A genome-wide scan of selective sweeps in two broiler chicken lines divergently selected for abdominal fat content.
Li et al., Harbin, China. In Bmc Genomics, 2011
A number of genes in the significant core regions, including RB1, BBS7, MAOA, MAOB, EHBP1, LRP2BP, LRP1B, MYO7A, MYO9A and PRPSAP1, were detected.
Hyperuricemia cosegregating with osteogenesis imperfecta is associated with a mutation in GPATCH8.
Ohno et al., Nagoya, Japan. In Hum Genet, 2011
After confirming lack of a founder haplotype in three families, we analyzed PRPSAP1 and PRPSAP2 as candidate genes for hyperuricemia on chr 17 where COL1A1 is located, but found no mutation.
[Increased activity of PRPP synthetase].
Iizasa, In Nihon Rinsho, 2008
Human PRPP synthetase exists as heterogeneous aggregates composed of the 34kDa catalytic subunits (PRSI and PRSII) and other 39kDa and 41kDa components designated PRPP synthetase-associated protein (PAP39 and PAP41).
Rat liver phosphoribosylpyrophosphate synthetase is activated by free Mg2+ in a manner that overcomes its inhibition by nucleotides.
Tatibana et al., Chiba, Japan. In Biochim Biophys Acta, 1998
The rat liver enzyme is a complex aggregate of two highly homologous catalytic subunits (PRS I and PRS II) and two associated proteins (PAP39 and PAP41).
Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein.
Itakura et al., Tokushima, Japan. In Biochim Biophys Acta, 1998
A human cDNA encoding 41-kDa phosphoribosylpyrophosphate (PRPP) synthetase (PRS)-associated protein (PAP41) was cloned from two expressed sequence tag (EST) clones having the nucleotide similarity of 61.5 and 70.0% to human PAP39 cDNA.
Cloning and sequencing of rat cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein has a high homology to the catalytic subunits and the 39-kDa associated protein.
Tatibana et al., Chiba, Japan. In Biochim Biophys Acta, 1997
Rat liver phosphoribosylpyrophosphate synthetase is a complex aggregate of 34-kDa catalytic subunits (PRS I and II) and 39- and 41-kDa associated proteins (PAP39 and 41).
[PRPP synthetase superactivity].
Fujimori, In Nihon Rinsho, 1996
Human PRS exists as complex aggregates composed of the 34 kDa catalytic subunits(PRS1 and PRS2) and other 39 kDa component designated PRPP synthetase-associated protein (PAP39).
[Mammalian phosphoribosylpyrophosphate synthetase].
Tatibana, Chiba, Japan. In Nihon Rinsho, 1996
PRPP synthetase from rat liver exists as large molecular weight aggregates composed of at least four different components, i.e., two isoforms of 34 kDa catalytic subunits, PRSI and PRSII, and two associated proteins of 39 kDa and 41 kDa (PAP39 and PAP41).
Promoter region of the rat phosphoribosylpyrophosphate synthetase-associated protein 39.
Tatibana et al., Chiba, Japan. In Biochim Biophys Acta, 1996
The 5' region of the 39-kDa rat phosphoribosylpyrophosphate synthetase-associated protein (PAP39) gene was isolated and sequenced.
Mammalian phosphoribosyl-pyrophosphate synthetase.
Ahmad et al., Chiba, Japan. In Adv Enzyme Regul, 1994
Another component, PRPP synthetase-associated protein of 39 kDa (PAP39), was cloned from cDNA library of the rat liver.
A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role.
Tatibana et al., Chiba, Japan. In J Biol Chem, 1994
We have cloned the cDNA for the major one of 39 kDa (PAP39) from a rat liver cDNA library.
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