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Pancreatic lipase

pancreatic lipase, pancreatic lipase,
This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, colipase, fibrillin-1
Papers on pancreatic lipase
Small quinolinium-based enzymatic probes via blue-to-red ratiometric fluorescence.
Zhang et al., Hefei, China. In Analyst, Feb 2016
Here the detection of β-galactosidase and porcine pancreatic lipase is successfully demonstrated and this class of molecules has the potential to be developed as a "naked-eye" probe in vitro.
Bioactive Compounds of Aristotelia chilensis Stuntz and Their Pharmacological Effects.
Di Fabio et al., Napoli, Italy. In Curr Pharm Biotechnol, Feb 2016
A broad range of activities of plant extracts and fractions are presented, including antioxidant activity, inhibition of visible light-induced damage of photoreceptor cells, inhibition of -glucosidase, inhibition of pancreatic lipase, anti-diabetic effects, anti-inflammatory effects, analgesic effects, anti-diabetes, effective prevention of atherosclerosis, promotion of hair growth, anti-photo ageing of the skin, and inhibition of lipid peroxidation.
Anti-obesity Effect of Dioscorea oppositifolia Extract in High-Fat Diet-Induced Obese Mice and Its Chemical Characterization.
Yang et al., In Biol Pharm Bull, Jan 2016
In our previous study, D. oppositifolia exhibited both pancreatic lipase inhibition and an anti-adipogenesis effect in vitro.
Medicinal Plants Traditionally Used for Treatment of Obesity and Diabetes Mellitus - Screening for Pancreatic Lipase and α-Amylase Inhibition.
Melzig et al., Berlin, Germany. In Phytother Res, Jan 2016
UNASSIGNED: In order to find new pancreatic lipase (PL) and α-amylase inhibitors from natural sources for the treatment of obesity and related diseases as diabetes mellitus II, 23 medicinal plants with weight-reducing, serum glucose-reducing or related potential were investigated.
Long-term effects of oral tea polyphenols and Lactobacillus brevis M8 on biochemical parameters, digestive enzymes, and cytokines expression in broilers.
Luo et al., Changsha, China. In J Zhejiang Univ Sci B, Dec 2015
Middle and high dosages of TP increased pancreatic lipase and proventriculus pepsin activities (P<0.05).
Horizons in the Pharmacotherapy of Obesity.
Arch, United Kingdom. In Curr Obes Rep, Dec 2015
In the recent past, only the low efficacy, pancreatic lipase inhibitor orlistat was available worldwide and it was little used.
The role of seaweed bioactives in the control of digestion: implications for obesity treatments.
Pearson et al., Newcastle upon Tyne, United Kingdom. In Food Funct, Dec 2015
This review discusses the effect of several of these components on the digestive processes within the gastrointestinal tract; focusing on the effect of alginate on pancreatic lipase activity and its potential health benefits.
Medicinal Plants and Their Inhibitory Activities against Pancreatic Lipase: A Review.
Mohamed et al., Kuala Lumpur, Malaysia. In Evid Based Complement Alternat Med, 2014
In order to find new compounds which are more effective or with less adverse effects compared to orlistat, the drug that has been approved for obesity, new compounds isolated from natural products are being identified and screened for antiobesity effects, in particular, for their pancreatic lipase inhibitory effect.
Shape based virtual screening and molecular docking towards designing novel pancreatic lipase inhibitors.
Talluri et al., Guntūr, India. In Bioinformation, 2014
Among the various targets linked to obesity, pancreatic lipase was one of the promising targets for obesity treatment.
Inhibitors of pancreatic lipase: state of the art and clinical perspectives.
Bhutani et al., India. In Excli J, 2013
Digestion and absorption of dietary lipids by pancreatic lipase, a major source of excess calorie intake, can be targeted for development of anti-obesity agents.
Glycomic and proteomic profiling of pancreatic cyst fluids identifies hyperfucosylated lactosamines on the N-linked glycans of overexpressed glycoproteins.
Novotny et al., Bloomington, United States. In Mol Cell Proteomics, 2012
Triacylglycerol lipase and alpha-amylase are highly over-expressed in pancreatic cyst fluids in patients with mucinous pancreatic neoplasms.
Modification of pancreatic lipase properties by directed molecular evolution.
Kerfelec et al., Marseille, France. In Protein Eng Des Sel, 2010
Combination of two mutations with a promising one at the entrance of the catalytic cavity (K80E) negatively affected the lipase activity at neutral pH but not that at acidic pH.
Amplitude of pancreatic lipase lid opening in solution and identification of spin label conformational subensembles by combining continuous wave and pulsed EPR spectroscopy and molecular dynamics.
Fournel et al., Marseille, France. In Biochemistry, 2010
the amplitude of the lid opening measured in solution or in a frozen solution in the presence of amphiphiles
Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt.
Lowe et al., Saint Louis, United States. In J Biol Chem, 2009
Trp-107 and Trp-253 contribute to the change in steady state fluorescence that is triggered by mixed micelles of inhibitor and bile salt.
Lid opening and unfolding in human pancreatic lipase at low pH revealed by site-directed spin labeling EPR and FTIR spectroscopy.
Fournel et al., Marseille, France. In Biochemistry, 2009
The disulfide bridge between the hinges of the lid kept the secondary structure of the lid intact, whereas the HPL was completely unfolded.
Constant darkness is a circadian metabolic signal in mammals.
Lee et al., Houston, United States. In Nature, 2006
Genes for murine procolipase (mClps) and pancreatic lipase-related protein 2 (mPlrp2) are activated in a circadian manner in peripheral organs during 12 h dark:12 h dark (DD) but not light-dark (LD) cycles.
Phase I trial of the anti-Lewis Y drug immunoconjugate BR96-doxorubicin in patients with lewis Y-expressing epithelial tumors.
LoBuglio et al., Birmingham, United States. In J Clin Oncol, 2000
The most common side effects were GI toxicity, fever, and elevation of pancreatic lipase.
Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.
Glimcher et al., Boston, United States. In Cell, 1990
By sequence homology, this gene is likely to be the mouse homolog of pancreatic lipase.
Human lipoprotein lipase complementary DNA sequence.
Lawn et al., In Science, 1987
Analysis of the sequence indicates that human lipoprotein lipase, hepatic lipase, and pancreatic lipase are members of a gene family.
Enzymatic catalysis in organic media at 100 degrees C.
Klibanov et al., In Science, 1984
Porcine pancreatic lipase catalyzes the transesterification reaction between tributyrin and various primary and secondary alcohols in a 99 percent organic medium.
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