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Acyl-CoA thioesterase 8

Palmitoyl-CoA Hydrolase
The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: ACID, HAD, catalase, CAN, ESI
Papers on Palmitoyl-CoA Hydrolase
Gene expression profiling in the type 1 diabetes rat diaphragm.
Moyer et al., Cleveland, United States. In Plos One, 2008
There was increased expression of genes involved in palmitoyl-CoA hydrolase activity (a component of lipid metabolism) (P = 0.037, n = 2 genes, fold change 4.2 to 27.5) and reduced expression of genes related to carbohydrate metabolism (P = 0.000061, n = 8 genes, fold change -2.0 to -8.5).
Nafamostat is hydrolysed by human liver cytosolic long-chain acyl-CoA hydrolase.
Watanabe et al., Kanazawa, Japan. In Xenobiotica, 2007
An isoform of long-chain acyl-CoA hydrolase may be responsible for the nafamostat hydrolysis in human liver cytosol.
The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.
Alexson et al., Huddinge, Sweden. In J Biol Chem, 2005
ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids
Sterol Regulatory Element-Binding Protein-2 modulates human brain acyl-CoA hydrolase gene transcription.
Yamada et al., Tokyo, Japan. In Mol Cell Biochem, 2005
SREBP2 modulates brain palmitoyl-coa hydrolase gene transcription.
Inducible expression of long-chain acyl-CoA hydrolase gene in cell cultures.
Junji et al., Hachiōji, Japan. In Mol Cell Biochem, 2003
Induction of BACH-MYC and an increase in palmitoyl-CoA hydrolase activity were observed in the cells treated with 3 x 10(-11) M mifepristone and reached maximal levels at a concentration of 1 x 10(-9) M for 48 h.
Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization.
Yamada et al., Hachiōji, Japan. In Brain Res Mol Brain Res, 2002
While palmitoyl-CoA hydrolase activity was widely distributed in mouse tissues, it was marked in the brain, consistent with mBACH being almost exclusively distributed in this tissue, where >80% of the enzyme activity was explained by mBACH present in the cytosol.
Nitric oxide reduces the palmitoylation of rat myelin proteolipid protein by an indirect mechanism.
Pastuszyn et al., Albuquerque, United States. In Neurochem Res, 2001
The NO-induced reduction in acyl-CoA concentration was due to the decline in ATP levels, while the amount of [3H]palmitate incorporated into the tissue, the activity of palmitoyl-CoA ligase and palmitoyl-CoA hydrolase, and the concentration of CoASH were unaltered by the drugs.
Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase.
Suga et al., Hachiōji, Japan. In J Biochem, 1999
In human brain cytosol, 85% of palmitoyl-CoA hydrolase activity was titrated by an anti-BACH antibody, which accounted for over 75% of the enzyme activity found in the brain tissue.
Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity.
Hofmann et al., Dallas, United States. In J Biol Chem, 1997
In the current study, we describe the cloning and expression of a second lysosomal thioesterase, palmitoyl-protein thioesterase 2 (PPT2), that shares an 18% identity with palmitoyl-protein thioesterase.
Molecular cloning and expression of cDNAs encoding rat brain and liver cytosolic long-chain acyl-CoA hydrolases.
Suga et al., Tokyo, Japan. In Biochem Biophys Res Commun, 1997
When expressed in Escherichia coli, these cDNAs produced palmitoyl-CoA hydrolase activity and 44-kDa proteins with molecular masses similar to those of purified rBACH and rLACH1 (43 kDa).
Cloning and sequencing of rat liver carboxylesterase ES-4 (microsomal palmitoyl-CoA hydrolase).
Beaufay et al., Brussels, Belgium. In Biochem J, 1996
A cDNA which encodes a carboxylesterase of 561 amino acid residues including a cleavable signal peptide is described.
Long-chain acyl-CoA hydrolase from rat brain cytosol: purification, characterization, and immunohistochemical localization.
Suga et al., Tokyo, Japan. In Arch Biochem Biophys, 1996
In the rat brain cytosol, about 90% of palmitoyl-CoA hydrolase activity was titrated by anti-ACH antibody, which accounted for over 70% of the enzyme activity found in the brain tissue.
Counter modulation of adipocyte mitochondrial processes by insulin and S-oxalylglutathione.
Kiechle et al., United States. In Int J Biochem Cell Biol, 1996
Palmitoyl-CoA hydrolase activity was decreased 14% by insulin treatment; however, S-oxalylglutathione caused a 14-50% increase in hydrolase activity.
Different effects of fibrates on the microsomal fatty acid chain elongation and the acyl composition of phospholipids in guinea-pigs.
Laguna et al., Barcelona, Spain. In Br J Pharmacol, 1995
3. Microsomal palmitoyl-CoA hydrolase and synthetase were also inhibited in vitro (GFB > or = BFB > CFB), whereas NADH cytochrome c reductase activity was increased by GFB.
Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates.
Laguna et al., Barcelona, Spain. In Br J Pharmacol, 1994
The time-course of the effect of clofibrate (CFB), bezafibrate (BFB) and gemfibrozil (GFB) on lipid plasma levels and palmitoyl-CoA hydrolase and synthetase activities, as well as the correlations with the peroxisomal proliferation phenomenon have been studied in male Sprague-Dawley rats.
Purification and properties of long-chain acyl-CoA hydrolases from the liver cytosol of rats treated with peroxisome proliferator.
Suga et al., Tokyo, Japan. In Arch Biochem Biophys, 1994
In the liver cytosol of rats treated with di(2-ethylhexyl)phthalate, about 90% of palmitoyl-CoA hydrolase activity was titrated with anti-ACH1 and anti-ACH2 antibodies.
Cholesterol induced lipid accumulation in myocardial cells of rats.
Berge et al., Bergen, Norway. In Cardiovasc Res, 1993
Palmitoyl-CoA hydrolase and fatty acyl-CoA oxidase were determined in total homogenate of hearts.
Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats.
Berge et al., Bergen, Norway. In J Lipid Res, 1993
Moreover, palmitoyl-CoA synthetase activity was increased, whereas the palmitoyl-CoA hydrolase activity was decreased.
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