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Palladin, cytoskeletal associated protein

This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: Actin, alpha-Actinin, CAN, ACID, OUT
Papers on Palladin
Actin Polymerization is Stimulated by Actin Crosslinking Protein Palladin.
Beck et al., Charlottesville, United States. In Biochem J, Dec 2015
UNASSIGNED: The actin scaffold protein palladin regulates both normal cell migration and invasive cell motility, processes that require the coordinated regulation of actin dynamics.
Palladin expression is a conserved characteristic of the desmoplastic tumor microenvironment and contributes to altered gene expression.
Kim et al., Chapel Hill, United States. In Cytoskeleton (hoboken), Aug 2015
Previous studies have shown that the actin-binding protein palladin is highly expressed in the stroma of pancreas tumors, but the interpretation of these results is complicated by the fact that palladin exists as multiple isoforms.
Palladin mediates stiffness-induced fibroblast activation in the tumor microenvironment.
Ligon et al., Troy, United States. In Biophys J, Aug 2015
Finally, we identify the actin-associated protein palladin as a key node in these signaling pathways that result in fibroblast activation.
Special AT-rich sequence-binding protein 2 suppresses invadopodia formation in HCT116 cells via palladin inhibition.
Senga et al., Nagoya, Japan. In Exp Cell Res, Apr 2015
Here, we show that SATB2 inhibits invadopodia formation in HCT116 cells and that the molecular scaffold palladin is inhibited by exogenous expression of SATB2.
Palladin is upregulated in kidney disease and contributes to epithelial cell migration after injury.
Otey et al., Chapel Hill, United States. In Sci Rep, 2014
In this study, we show that palladin, a previously characterized cytoskeletal protein, is upregulated in injured tubules and suggest that one of its functions during repair is to facilitate migration of remaining cells to the affected site.
Dual roles of palladin protein in in vitro myogenesis: inhibition of early induction but promotion of myotube maturation.
Wang et al., Tainan City, Taiwan. In Plos One, 2014
Palladin is a microfilament-associated phosphoprotein whose function in skeletal muscle has rarely been studied.
Actin dynamics regulate subcellular localization of the F-actin-binding protein PALLD in mouse Sertoli cells.
Geyer et al., Chapel Hill, United States. In Reproduction, 2014
Palladin (PALLD) is a widely expressed F-actin-binding and bundling protein recently shown to regulate these structures, yet it is predominantly nuclear in Sertoli cells at puberty.
Actin-associated protein palladin is required for migration behavior and differentiation potential of C2C12 myoblast cells.
Wang et al., Tainan City, Taiwan. In Biochem Biophys Res Commun, 2014
The actin-associated protein palladin has been shown to be involved in differentiation processes in non-muscle tissues.
Palladin promotes assembly of non-contractile dorsal stress fibers through VASP recruitment.
Lappalainen et al., Helsinki, Finland. In J Cell Sci, 2014
Palladin is a multidomain protein, which associates with stress fibers in a variety of cell types.
Palladin regulation of the actin structures needed for cancer invasion.
El-Sibai et al., Beirut, Lebanon. In Cell Adh Migr, 2013
Palladin, a molecular scaffold, co-localizes with actin-rich structures where it plays a role in their assembly and maintenance in a wide variety of cell lines.
Structure and function of palladin's actin binding domain.
Campbell et al., Chapel Hill, United States. In J Mol Biol, 2013
Here, we report the NMR structure of the actin-binding domain contained in the cell adhesion protein palladin.
Arousal of cancer-associated stroma: overexpression of palladin activates fibroblasts to promote tumor invasion.
Chen et al., Seattle, United States. In Plos One, 2011
A model whereby palladin-activated fibroblasts facilitate stromal-dependent metastasis and outgrowth of tumorigenic epithelium.
Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas.
Nasir et al., Tampa, United States. In Anticancer Res, 2011
Palladin may identify primary pancreatic endocrine neoplasms with a propensity to metastasize to the liver
Palladin is a novel binding partner of ILKAP in eukaryotic cells.
Zhang et al., Changchun, China. In Biochem Biophys Res Commun, 2011
these results suggested that palladin played a specific role in modulating the subcellular localization of the cytoplasmic ILKAP and promoting the ILKAP-induced apoptosis.
The actin associated protein palladin in smooth muscle and in the development of diseases of the cardiovasculature and in cancer.
Jin, Charlottesville, United States. In J Muscle Res Cell Motil, 2011
Palladin is an actin associated protein serving as a cytoskeleton scaffold, and actin cross linker, localizing at stress fibers, focal adhesions, and other actin based structures.
Elevated expression of stromal palladin predicts poor clinical outcome in renal cell carcinoma.
Cukierman et al., Philadelphia, United States. In Plos One, 2010
Observations support the belief that stromal palladin assessments have clinical relevance thus validating the use of these 3D cultures to study both progressive RCC-associated stroma and stroma-dependent mechanisms affecting tumorigenesis.
Role of palladin phosphorylation by extracellular signal-regulated kinase in cell migration.
Senga et al., Nagoya, Japan. In Plos One, 2010
results indicate that palladin phosphorylation by ERK has an anti-migratory function, possibly by modulating interactions with molecules that regulate cell migration
The role of palladin in actin organization and cell motility.
Otey et al., Chapel Hill, United States. In Eur J Cell Biol, 2008
Palladin is a widely expressed protein found in stress fibers, focal adhesions, growth cones, Z-discs, and other actin-based subcellular structures.
[Basic directions of research of the department of lipid biochemistry].
Hula, Kiev, Ukraine. In Ukr Biokhim Zh (1999), 2000
The review deals with the scientific activity of the Department of Biochemistry of Lipids of the Palladin Biochemistry Institute of the National Academy of Sciences of Ukraine.
[The role of vitamin E in the body].
Khalmuradov et al., In Ukr Biokhim Zh, 1985
The basic experimental data obtained at the Department of Coenzymes' Biochemistry of the A. V. Palladin Institute of Biochemistry of the Ukr.
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