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Paired immunoglobin-like type 2 receptor alpha

paired immunoglobulin-like receptor, paired immunoglobulin-like type 2 receptor, PILRA, paired immunoglobulinlike receptor A, paired immunoglobin-like receptor, FDF03, paired immunoglobulin-like type 2 receptor alpha
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PIR, ILT5, CD45, Nogo, CAN
Papers on paired immunoglobulin-like receptor
The Binding Receptors of Aβ: an Alternative Therapeutic Target for Alzheimer's Disease.
Xiong et al., Chongqing, China. In Mol Neurobiol, Jan 2016
These receptors include the cellular prion protein (PrPc), the α7 nicotinic acetylcholine receptor (α7nAChR), the p75 neurotrophin receptor (p75(NTR)), the beta-adrenergic receptors (β-ARs), the Eph receptors, the paired immunoglobulin-like receptor B (PirB), the PirB's human ortholog receptor (LilrB2), and the Fcγ receptor II-b (FcγRIIb).
Experimental and Clinical Advances in Immunotherapy Strategies for Spinal Cord Injury Target on MAIs and Their Receptors.
Wang et al., Chongqing, China. In Curr Pharm Des, Jan 2016
Interestingly, these three structurally different inhibitors share two common receptors, Nogo-66 receptor (NgR) and paired immunoglobulin-like receptor B (PirB), and transduce the inhibitory signal into neurons via their complex combinant and co-receptors, such as p75 neurotrophin receptor (p75NTR), Nogo receptor-interacting protein 1 (LINGO-1), and TROY.
Cloning and identification of splice variants of the porcine PILRA gene.
Xiuqin et al., Harbin, China. In Yi Chuan, Sep 2015
In order to analyze the potential role of PILRα in porcine disease-resistant breeding, we first cloned the PILRA gene (V1-V3, GenBank accession Nos.
ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells.
Zheng et al., Shanghai, China. In Oncotarget, Sep 2015
Recently we demonstrated that leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) and its murine homolog, paired immunoglobulin-like receptor B (PIRB), are expressed on hematopoietic stem cells and acute myeloid leukemia stem cells and function in maintenance of stemness.
Axon regeneration impediment: the role of paired immunoglobulin-like receptor B.
Fu et al., Beijing, China. In Neural Regen Res, Aug 2015
In addition to the Nogo receptor (NgR), the paired immunoglobulin-like receptor B (PirB) is a recently discovered coreceptor of Nogo, myelin-associated glycoprotein, and myelin oligodendrocyte glycoprotein.
Distribution of paired immunoglobulin-like receptor B in the nervous system related to regeneration difficulties after unilateral lumbar spinal cord injury.
Li et al., Taiyuan, China. In Neural Regen Res, Jul 2015
Paired immunoglobulin-like receptor B (PirB) is a functional receptor of myelin-associated inhibitors for axonal regeneration and synaptic plasticity in the central nervous system, and thus suppresses nerve regeneration.
Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System.
Filbin et al., United States. In J Biol Chem, Jul 2015
All three inhibitors can interact with either the Nogo receptor complex or paired immunoglobulin-like receptor B. A conditioning lesion of the sciatic nerve allows the central processes of dorsal root ganglion (DRG) neurons to spontaneously regenerate in vivo after a dorsal column lesion.
Maintaining stable memory engrams: new roles for Nogo-A in the CNS.
Korte et al., Braunschweig, Germany. In Neuroscience, 2015
Nogo-A interaction with its different receptors (Nogo receptor 1 (NgR1), S1P receptor 2 (S1PR2), paired immunoglobulin-like receptor B (PirB)) restricts plasticity and growth-dependent processes leading, via the activation of different signaling pathway to the stabilization of the neuronal networks (either developmentally or during processes of memory consolation in the mature nervous system).
PD-L1 blockade improves immune dysfunction of spleen dendritic cells and T-cells in zymosan-induced multiple organs dysfunction syndromes.
Lu et al., Beijing, China. In Int J Clin Exp Pathol, 2014
The immunity of DC was determined by examining interleukin (IL)-10, IL-12, IL-2, major histocompatibility complex (MHC), CD86, programmed death (PD-1), programmed death ligand 1 (PD-L1), paired immunoglobulin-like receptor B (PIR-B) or T-cell proliferation in serum, spleen homogenate, DC culture or DC/T-cell co-culture.
PirB is a novel potential therapeutic target for enhancing axonal regeneration and synaptic plasticity following CNS injury in mammals.
Gou et al., Nanchong, China. In J Drug Target, 2014
However, paired immunoglobulin-like receptor B (PirB) - which was originally identified as a receptor for class I major histocompatibility complex (MHCI) in the immune system - is also expressed in neurones and plays a similarly inhibitory role in axonal regeneration and synaptic plasticity following CNS injury through its association with MAIs.
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Shatz et al., Stanford, United States. In Science, 2013
We report that murine PirB (paired immunoglobulin-like receptor B) and its human ortholog LilrB2 (leukocyte immunoglobulin-like receptor B2), present in human brain, are receptors for Aβ oligomers, with nanomolar affinity.
Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.
Arase et al., Ōsaka, Japan. In Nat Immunol, 2013
Here we found that paired immunoglobulin-like type 2 receptor alpha (PILRα), an inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs), negatively regulated neutrophil infiltration during inflammation.
Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.
Zhang et al., Dallas, United States. In Nature, 2012
Here we show that the immune-inhibitory receptor human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse orthologue paired immunoglobulin-like receptor (PIRB) are receptors for several ANGPTLs.
Evolutionarily conserved paired immunoglobulin-like receptor α (PILRα) domain mediates its interaction with diverse sialylated ligands.
Zarrin et al., San Francisco, United States. In J Biol Chem, 2012
Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human).
Amino acid differences in glycoproteins B (gB), C (gC), H (gH) and L (gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor α.
Kousoulas et al., Baton Rouge, United States. In Virol J, 2011
The authors show that the human ocular and highly neurovirulent HSV-1 strain McKrae enters substantially more efficiently into cells via the gB-specific human paired immunoglobulin-like type-2 receptor-alpha (hPILR-alpha).
Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells.
Chen et al., New York City, United States. In Immunity, 2011
Herein, we investigate the potential function of paired immunoglobulin-like receptor B (PIR-B), also known as leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) in MDSC differentiation, and its role in tumor-induced immunity.
PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues.
Arase et al., Ōsaka, Japan. In Biochem Biophys Res Commun, 2011
These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.
Differential effects on cell fusion activity of mutations in herpes simplex virus 1 glycoprotein B (gB) dependent on whether a gD receptor or a gB receptor is overexpressed.
Spear et al., Chicago, United States. In J Virol, 2009
Insertional mutations of gB reduced cell fusion activity when PILRalpha was overexpressed much more than nectin-1.
Entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor alpha.
Kawaguchi et al., Tokyo, Japan. In J Virol, 2009
viral entry via PILRalpha appears to be conserved but that there is a PILRalpha preference among alphaherpesviruses
PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Tessier-Lavigne et al., San Francisco, United States. In Science, 2008
With the use of expression cloning, we have found that paired immunoglobulin-like receptor B (PirB), which has been implicated in nervous system plasticity, is a high-affinity receptor for Nogo, MAG, and OMgp.
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