Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity.
Berkeley, United States. In Chem Biol, 2014
In this study, we used metabolic mapping platforms to identify biochemical drivers of cellular transformation and malignant progression driven through RAS and the Hippo pathway in breast cancer and identified platelet-activating factor acetylhydrolase 1B3 (PAFAH1B3) as a key metabolic driver of breast cancer pathogenicity that is upregulated in primary human breast tumors and correlated with poor prognosis.
Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas.
London, United Kingdom. In Cancer, 2014
RESULTS: Here, we investigated 8 FOXM1-induced differentially methylated genes, SPCS1, FLNA, CHPF, GLT8D1, C6orf136, MGAT1, NDUFA10, and PAFAH1B3, using human head and neck tissue specimens donated by 2 geographically independent patient cohorts from Norway and the United Kingdom.