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Phosphofurin acidic cluster sorting protein 1

PACS-1, phosphofurin acidic cluster sorting protein 1
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: S-100, AP-1, MHC, ACID, fibrillin-1
Papers on PACS-1
Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways.
Dikeakos et al., London, Canada. In Plos One, 2014
Using the F2A cleavage site from the foot and mouth disease virus we generated a viral BiFC expression vector capable of concurrent expression of Nef and host cellular proteins; PACS-1, MHC-I and SNX18.
Evaluation of Five Phase Digitally Controlled Rotating Field Plasma Source for Photochemical Mercury Vapor Generation Optical Emission Spectrometry.
Portalski et al., Poznań, Poland. In Anal Sci, 2014
The methodology was validated through determination of mercury in three certified reference materials (corresponding to biological and environmental samples) (NRCC DOLT-2, NRCC PACS-1, NIST 2710) using the external aqueous standard calibration techniques in acetic acid media, with satisfactory recoveries.
SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.
Willnow et al., Berlin, Germany. In Mol Cell Biol, 2013
We focused on the interaction of SORLA with phosphofurin acidic cluster sorting protein 1 (PACS1), an adaptor that shuttles proteins between the trans-Golgi network (TGN) and endosomes.
Determination of vanadium in soils and sediments by the slurry sampling graphite furnace atomic absorption spectrometry using permanent modifiers.
Otto et al., Lublin, Poland. In Talanta, 2013
The results obtained for the four certified reference materials (marine sediments: PACS-1 and MESS-1, lake sediment: SL-1, soil: San Joaquin Soil SRM 2709), using the slurry sampling GFAAS and the standard calibration method, were in good agreement with the certified values.
Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13.
Kleine-Lowinski et al., Essen, Germany. In Cancer Genet, 2013
Apart from the known differentially expressed genes on 11q13 (e.g., phosphofurin acidic cluster sorting protein 1 (PACS1) and FOS ligand 1 (FOSL1 or Fra-1)), we detected novel differentially expressed cellular genes located within the tumor suppressor gene region (e.g., EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) and leucine rich repeat containing 32 (LRRC32) (also known as glycoprotein-A repetitions predominant (GARP)) that may have potential tumor suppressor functions in this model system of non-tumorigenic and tumorigenic HeLa x fibroblast hybrid cells.
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
Farooqi et al., Cambridge, United Kingdom. In Nat Genet, 2013
Evaluation of 29 SNPs (P < 1 × 10(-5)) in an additional 971 severely obese children and 1,990 controls identified 4 new loci associated with severe obesity (LEPR, PRKCH, PACS1 and RMST).
Recurrent de novo mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome.
Brunner et al., Nijmegen, Netherlands. In Am J Hum Genet, 2013
Exome sequencing in both families identified identical de novo mutations in PACS1, suggestive of causality.
Role of adaptor proteins in secretory granule biogenesis and maturation.
Mains et al., Farmington, United States. In Front Endocrinol (lausanne), 2012
AP-1A recruitment to membranes can be modulated by Phosphofurin Acidic Cluster Sorting protein 1 (PACS-1), a cytosolic protein which interacts with both AP-1A and cargo that has been phosphorylated by casein kinase II.
Characterization and intracellular trafficking of Epstein-Barr virus BBLF1, a protein involved in virion maturation.
Hung et al., Madison, United States. In J Virol, 2012
The localization of BBLF1 at the TGN requires myristoylation and two acidic clusters, which interact with PACS-1, a cytosolic protein, to mediate retrograde transport from the endosomes to the TGN.
An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.
Thomas et al., Portland, United States. In Mol Biol Cell, 2012
The sites on Nef and the PACS proteins required for their interaction, are identified.
Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia.
Schermer et al., Köln, Germany. In J Biol Chem, 2011
NPHP4 counteracts Pyk2-mediated phosphorylation of three defined tyrosine residues of NPHP1 thereby controlling binding of NPHP1 to the trans-Golgi sorting protein PACS-1.
PACS-1 mediates phosphorylation-dependent ciliary trafficking of the cyclic-nucleotide-gated channel in olfactory sensory neurons.
Martens et al., Ann Arbor, United States. In J Neurosci, 2009
PACS-1 mediates phosphorylation-dependent ciliary trafficking of the CNGB1b in olfactory sensory neurons.
A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.
Thomas et al., Portland, United States. In Embo J, 2006
CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported.
Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia.
Benzing et al., Freiburg, Germany. In Embo J, 2006
casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation.
Walz et al., Freiburg, Germany. In Embo J, 2005
subcellular localization and function of polycystin-2 are directed by phosphofurin acidic cluster sorting protein (PACS)-1 and PACS-2
HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.
Thomas et al., Portland, United States. In Cell, 2003
PACS-1 along with HIV-1 nef, has a role in downregulating cell surface MHC-I to the trans-Golgi network and usurping the ARF6 endocytic pathway
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.
Trono et al., Genève, Switzerland. In Nat Cell Biol, 2000
Here we show that Nef-induced downregulation of MHC-I expression and MHC-I targeting to the TGN require the binding of Nef to PACS-1, a molecule that controls the TGN localization of the cellular protein furin.
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization.
Thomas et al., Portland, United States. In Cell, 1998
We report the role of one member of a novel gene family, PACS-1, in the localization of trans-Golgi network (TGN) membrane proteins.
Elemental speciation analysis by multicapillary gas chromatography with microwave-induced plasma atomic spectrometric detection.
Lobiński et al., Talence, France. In Anal Chem, 1998
MC-GC/MIP-AES was validated for the analysis of sediment (PACS-1 and BCR 462) and biological (NIES11) certified reference materials.
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