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Adenylate cyclase activating polypeptide 1

regulatory protein that stimulates cell proliferation, induces differentiation, modulates neurotransmitter release, vasodilation, bronchodilation, and hormone release, and suppresses inflammatory responses [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Neuropeptide, Vasoactive Intestinal Peptide, V1a, CAN, HAD
Papers using PACAP antibodies
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Figueiredo-Pereira M E et al., In Cell Death & Disease, 1982
... The substrate Suc-LLVY-AMC and the peptide PACAP27 were from BACHEM Bioscience Inc ...
Papers on PACAP
Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer.
Jensen et al., Bethesda, United States. In Curr Opin Endocrinol Diabetes Obes, Feb 2016
PURPOSE OF REVIEW: To summarize the roles of vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase activating polypeptide (PACAP) and their receptors (VPAC1, VPAC2, PAC1) in human tumors as well as their role in potential novel treatments.
Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo.
Takeuchi et al., Ōsaka, Japan. In Neurogastroenterol Motil, Feb 2016
Furthermore, when a PACAP antagonist was added following the EFS, sustained relaxation in NCX1 HET and NCX2 HET was not observed, similar to WT. Next, we examined the effect of NCX heterozygous deficiency on relaxation in response to NO and PACAP in smooth muscles.
Seizure-Induced Sympathoexcitation Is Caused by Activation of Glutamatergic Receptors in RVLM That Also Causes Proarrhythmogenic Changes Mediated by PACAP and Microglia in Rats.
Farnham et al., Sydney, Australia. In J Neurosci, Feb 2016
Pituitary adenylate cyclase activating polypeptide (PACAP) is an excitatory neuropeptide with neuroprotective properties, whereas microglia are key players in inflammatory responses in CNS.
Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration.
Babich et al., New York City, United States. In Ann N Y Acad Sci, Feb 2016
Further, we discuss our work showing that increasing intracellular cAMP with the lipophilic peptide PACAP27 counteracts some of the PGJ2-induced detrimental effects.
Pituitary Adenylate Cyclase Activating Polypeptide, A Potential Therapeutic Agent for Diabetic Retinopathy in Rats: Focus on the Vertical Information Processing Pathway.
Gabriel et al., Pécs, Hungary. In Neurotox Res, Feb 2016
UNASSIGNED: Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophic and neuroprotective peptide that has been shown to exert protective effects in different neuronal injuries, such as retinal degenerations.
Effect of the pituitary adenylate cyclase-activating polypeptide on the autophagic activation observed in in vitro and in vivo models of Parkinson's disease.
Fournier et al., Mont-Saint-Aignan, France. In Biochim Biophys Acta, Feb 2016
This phenomenon is related to apoptosis and its activation can be blocked by the pituitary adenylate cyclase-activating polypeptide (PACAP).
Altered Circadian Food Anticipatory Activity Rhythms in PACAP Receptor 1 (PAC1) Deficient Mice.
Fahrenkrug et al., Copenhagen, Denmark. In Plos One, Dec 2015
Two neurotransmitters, glutamate and Pituitary Adenylate Cyclase Activating Polypeptide (PACAP), found in the ipRGCs transmit light signals to the brain via glutamate receptors and the specific PACAP type 1 (PAC1) receptor.
PACAP as a neuroprotective factor in ischemic neuronal injuries.
Nakamachi et al., Tokyo, Japan. In Peptides, Oct 2015
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family.
Therapeutic potential of PACAP for neurodegenerative diseases.
Xin et al., In Cell Mol Biol Lett, Jun 2015
Pituitary adenylate cyclase activating polypeptide (PACAP) is widely expressed in the central and peripheral nervous system.
Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications.
Castorina et al., Catania, Italy. In Int J Endocrinol, 2014
In this review, we will firstly summarize some of the major complications of diabetes, including endothelial and pancreatic islets dysfunction, retinopathy, and nephropathy, and then discuss the emerging roles exerted by the neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) to counteract these ranges of pathologies that are precipitated by the prolonged hyperglycemic state.
An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.
Lowell et al., Boston, United States. In Nature, 2014
Here, through the use of Cre-recombinase-enabled, cell-specific neuron mapping techniques in mice, we have discovered strong excitatory drive that, unexpectedly, emanates from the hypothalamic paraventricular nucleus, specifically from subsets of neurons expressing thyrotropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also known as ADCYAP1).
Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma.
Inazawa et al., Tokyo, Japan. In Clin Cancer Res, 2012
methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in hepatocarcinogenesis
[Proteomics-based identification of proapoptotic caspase adapter protein as a novel serum marker of non-small cell lung cancer].
Huang et al., Changsha, China. In Zhongguo Fei Ai Za Zhi, 2012
Data show that proapoptotic caspase adapter protein PACAP is a potential serum marker of non-small cell lung cancer.
Pituitary adenylate cyclase-activating peptide and vasoactive intestinal polypeptide bias Langerhans cell Ag presentation toward Th17 cells.
Granstein et al., United States. In Eur J Immunol, 2012
PACAP and VIP are endogenous mediators that likely regulate immunity and immune-mediated diseases within the skin.
Targeted pituitary overexpression of pituitary adenylate-cyclase activating polypeptide alters postnatal sexual maturation in male mice.
Winters et al., Louisville, United States. In Endocrinology, 2012
PACAP affects gonadotropin expression and sexual maturation in vivo
Peripheral and central alterations of pituitary adenylate cyclase activating polypeptide-like immunoreactivity in the rat in response to activation of the trigeminovascular system.
Tajti et al., Szeged, Hungary. In Peptides, 2012
The selective increases in both forms of PACAP in the trigeminal nucleus caudalis suggest its important role in the central sensitization involved in migraine-like headache.
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor.
May et al., United States. In Nature, 2011
data suggest that perturbations in the PACAP-PAC1 pathway are involved in abnormal stress responses underlying post-traumatic stress disorder
Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.
Vaudry et al., Mont-Saint-Aignan, France. In Pharmacol Rev, 2009
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid C-terminally alpha-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract on the basis of its ability to stimulate cAMP formation in anterior pituitary cells (Miyata et al., 1989.
Nonclassic endogenous novel [corrected] regulators of angiogenesis.
Nussdorfer et al., Bari, Italy. In Pharmacol Rev, 2007
An in vivo and in vitro proangiogenic effect has been demonstrated for erythropoietin, angiotensin II (ANG-II), endothelins (ETs), adrenomedullin (AM), proadrenomedullin N-terminal 20 peptide (PAMP), urotensin-II, leptin, adiponectin, resistin, neuropeptide-Y, vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), and substance P.
The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei.
Hastings et al., Edinburgh, United Kingdom. In Cell, 2002
The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian rhythms in the suprachiasmatic nuclei (SCN).
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