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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Phosphoinositide-3-kinase, regulatory subunit 3

p55gamma, p55PIK, PIK3R3
regulatory subunit of phosphatidylinositol 3-kinase, a mediator of various cellular signaling mechanisms; may mediate signaling in brain and muscle [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PI3K, CAN, Insulin, p85, Akt
Papers using p55gamma antibodies
A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy
Yen Paul Michael et al., In BMC Medical Genomics, 2007
... Effects of PIK3R3 knockdown on cell cycle progression and cell signaling of TMK1 GC cells ...
Papers on p55gamma
Rare copy number variants implicated in posterior urethral valves.
Mills et al., Bethesda, United States. In Am J Med Genet A, Jan 2016
Other interesting CNVs, each detected in a single PUV case included: a deletion of PIK3R3 and TSPAN1, duplication/triplication in FGF12, duplication of FAT1-a gene essential for normal growth and development, a large deletion (>2 Mb) on chromosome 17q that involves TBX2 and TBX4, and large duplications (>1 Mb) on chromosomes 3q and 6q.
KIT over-expression by p55PIK-PI3K leads to Imatinib-resistance in patients with gastrointestinal stromal tumors.
Wang et al., Wuhan, China. In Oncotarget, Nov 2015
In this study, we demonstrate that p55PIK, an isoform of phosphoinositide 3-kinase (PI3K), increases KIT expression, leading to IMA-resistance in GISTs by activating NF-κB signaling pathway.
MiR-132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3.
Shi et al., Changchun, China. In Int J Oncol, Oct 2015
In addition, phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) was identified as a direct target of miR‑132 by a luciferase reporter assay.
Upregulation of HOXB7 promotes the tumorigenesis and progression of gastric cancer and correlates with clinical characteristics.
Wu et al., Hangzhou, China. In Tumour Biol, Sep 2015
HOXB7 is generally overexpressed in GC, associated with patient clinical characteristics, and specifically promotes GC cell malignant biological properties through PIK3R3/AKT signaling pathways, indicating HOXB7 as a causal factor in promoting tumor progression.
MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3.
Liu et al., Shanghai, China. In Tumour Biol, Jun 2015
Phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) was identified as a direct target of miR-511 and miR-511 expression inversely correlated with PIK3R3 mRNA expression in clinical HCC tissues.
Mechanisms by which the N-terminal 24 amino acids of the p55 regulatory subunit of phosphatidylinositol 3-kinase affect endotoxin-induced cytokine release in human keratinocytes.
Wang et al., Zhengzhou, China. In Mol Med Report, May 2015
To understand the association between the cytokine network and psoriasis, the present study cultured human keratinocytes (HaCaT cells) and investigated the effects of the phosphatidylinositol‑3‑kinase (PI3K) p55 regulatory subunit (p55PIK), and its N‑terminal 24 amino acids (N24) on the regulation of endotoxin (LPS)‑induced cytokine secretion.
Phospho-tyrosine dependent protein-protein interaction network.
Stelzl et al., Berlin, Germany. In Mol Syst Biol, Mar 2015
Using binding assays, protein complementation and phenotypic readouts to characterize the pY-dependent interactions of TSPAN2 (tetraspanin 2) and GRB2 or PIK3R3 (p55γ), we exemplarily provide evidence that the two pY-dependent PPIs dictate cellular cancer phenotypes.
Whole genomes redefine the mutational landscape of pancreatic cancer.
Grimmond et al., Brisbane, Australia. In Nature, Mar 2015
A significant proportion harboured focal amplifications, many of which contained druggable oncogenes (ERBB2, MET, FGFR1, CDK6, PIK3R3 and PIK3CA), but at low individual patient prevalence.
In vitro activity of the mTOR inhibitor everolimus, in a large panel of breast cancer cell lines and analysis for predictors of response.
Slamon et al., Los Angeles, United States. In Breast Cancer Res Treat, Feb 2015
Transcript expression microarrays identified GSK3A, PIK3R3, KLF8, and MAPK10 among the genes overexpressed in sensitive luminal lines, while PGP, RPL38, GPT, and GFAP were among the genes overexpressed in resistant luminal cell lines.
Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes.
Jedlicka et al., Aurora, United States. In Plos One, 2014
In the present study, we identify variable expression of two modifiers of PI3K signaling activity, PIK3R3 and PTEN, in Ewing Sarcoma, and examine the consequences of this on PI3K pathway regulation and oncogenic phenotypes.
The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells.
Elliott et al., Glasgow, United Kingdom. In Oncoscience, 2014
We find that the PI3K regulatory subunits PIK3R1 (p85α) and PIK3R3 (p55γ) are direct targets of the AR which are rapidly repressed by androgens in LNCaP cells.
Overexpression of X-Box Binding Protein 1 (XBP1) Correlates to Poor Prognosis and Up-Regulation of PI3K/mTOR in Human Osteosarcoma.
Yang et al., Shanghai, China. In Int J Mol Sci, 2014
Most importantly, knockdown of XBP1 led to down-regulation of PIK3R3 and mTOR.
Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex.
Ryan et al., Bethesda, United States. In Plos One, 2014
In each interval, ITPKB, PLCD1, PIK3R3, ISYNA1, IMPA2, INPPL1, PI4KB, and AKT1 are in Group 1, PIK3CB, PTEN, PIK3CA, and IMPA1 in Group 2, and SACM1L, PI3KR4, INPP5A, SYNJ1, and PLCB1 in Group 3.
Microarray-based identification of differentially expressed genes in extramammary Paget's disease.
Xu et al., Shanghai, China. In Int J Clin Exp Med, 2014
Real-time PCR was conducted to verify the differential expression of some representative genes, including ERBB4, TCF3, PAPSS2, PIK3R3, PRLR, SULT1A1, TCF7L1, and CREB3L4.
SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma.
Demoulin et al., Brussels, Belgium. In J Lipid Res, 2007
We have identified novel nonclassical mediators of the SREBP-1 response, including p55gamma, supporting the hypothesis that SREBP-1 regulates stress response and signaling genes.
Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma.
Phillips et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2007
IGF2-PIK3R3 signaling axis is involved in promoting the growth of a subclass of highly aggressive human glioblastomas that lack EGF receptor amplification.
Estrogen modulation of hypothalamic neurons: activation of multiple signaling pathways and gene expression changes.
Rønnekleiv et al., Portland, United States. In Steroids, 2005
Some of these include gec-1, PI3-kinase p55gamma, rab11a GTPase, synaptobrevin2, synaptogyrin, taxilin, Ca2+-dependent activator protein for secretion (CAPS) and a number of proteins containing pleckstrin homology domains-domains that are involved in plasma membrane targeting of their host protein.
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