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Tumor protein p53

p53, TP53
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, bcl-2, PrP, V1a, HAD
Papers using p53 antibodies
Efficient RNA interference in patientśacute lymphoblastic leukemia cells amplified as xenografts in mice
Jeremias I et al., In Cell Death & Disease, 2011
... AIF, anti BAK, anti BAX, anti BCL-2, anti cIAP-2, anti Histone H1, anti-Mcl-1 and anti p53 from Santa Cruz Biotechnology Inc ...
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
Futscher Bernard W., In PLoS ONE, 2010
... µg/ml pepstatin A, 1 mM phenylmethylsulfonyl fluoride and immunoprecipitations performed with anti-Flag M2 (Sigma F3165) or anti-p53 DO-1 (Santa Cruz Biotechnology sc-126) monoclonal antibodies essentially ...
Are the pure in situ breast ductal carcinomas and those associated with invasive carcinoma the same?
Rao Roshni et al., In International Journal of Breast Cancer, 2009
... ER (clone 1D5, 1 : 800), PR (PgR 636, 1 : 1000) and Ki67 (MIB-1, 1 : 300), HER2/neu (1 : 600), and p53 (DO-7, 1 : 2200, Dako, Carpenteria, Calif, USA) ...
Phosphatidylinositol 3-kinase-C2beta inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma
Aspenstrom Pontus, In PLoS ONE, 2009
... , 9E10 myc epitope, p115RhoGEF, Dbl, Caveolin-2, Grb2, Src, RhoA, GFP, p53 (Santa Cruz Biotechnology, Santa Cruz, CA, USA); ...
A versatile molecular tagging method that targets proteins to avian reovirus protein muNS inclusions. Use in Protein Immobilization and Purification.
Mitraki Anna, In PLoS ONE, 2009
... Polyclonal antibody against p53 was obtained from Santa Cruz Biotechnology (Santa Cruz, California) ...
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Papers on p53
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Zanier et al., Illkirch-Graffenstaden, France. In Nature, Feb 2016
UNASSIGNED: The p53 pro-apoptotic tumour suppressor is mutated or functionally altered in most cancers.
Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice.
Greenberger et al., Pittsburgh, United States. In Radiat Res, Feb 2016
Oral mucosa of Fancd2(-/-) mice showed baseline elevated RNA transcripts for Sod2, p53, p21 and Rad51 (all P < 0.0012) and suppressed levels of Nfkb and Tgfb, (all P < 0.0020) compared with Fancd2(+/+) mice.
Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care.
Campbell et al., Newcastle, Australia. In J Clin Oncol, Feb 2016
A significant excess of mutations was only observed for PALB2 (26 cases, four controls) and TP53 (five cases, zero controls), whereas no mutations were identified in STK11.
p53 as guardian of the mitochondrial genome.
Hwang et al., Bethesda, United States. In Febs Lett, Feb 2016
UNASSIGNED: Participating in the repair of nuclear DNA is one mechanism by which p53 suppresses tumorigenesis, but there is growing evidence that p53 also helps maintain the mitochondrial genome through its translocation into mitochondria and interactions with mtDNA repair proteins.
p53 Reactivation by PRIMA-1(Met) (APR-246) sensitises (V600E/K)BRAF melanoma to vemurafenib.
Ghanem et al., Brussels, Belgium. In Eur J Cancer, Feb 2016
Given that p53 is capable of antagonising PI3K/AKT activation we hypothesised that pharmacological restoration of p53 activity may increase the sensitivity of BRAF-mutant melanoma to MAPK-targeted therapy and eventually delay and/or prevent acquisition of drug resistance.
Therapy-related myeloid neoplasms: what's in a name?
Tray et al., New York City, United States. In Curr Opin Hematol, Feb 2016
Acquired somatic mutations in genes such as TP53 and myeloid skewing with associated mutations in cancer-free older adults may predispose such individuals to tMN under the influence of myelosuppressive therapy, and this may be a route to the development of a subset of tMN.
A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models.
Accardi et al., Roma, Italy. In Oncotarget, Feb 2016
In SiHa cells, I7nuc expressed by pLNCX retroviral vector was able to partially inhibit degradation of the main E6 target p53, and induced p53 accumulation in nucleus.
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.
Agami et al., Amsterdam, Netherlands. In Nat Biotechnol, Feb 2016
We identified several functional enhancer elements and characterized the role of two of them in mediating p53 (TP53) and ERα (ESR1) gene regulation.
A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.
Eisenberg et al., United States. In Cancer Cell, Feb 2016
Half of all human cancers lose p53 function by missense mutations, with an unknown fraction of these containing p53 in a self-aggregated amyloid-like state.
Cellular functions of programmed cell death 5.
Chen et al., Beijing, China. In Biochim Biophys Acta, Feb 2016
PDCD5 regulates the activities of TIP60, HDAC3, MDM2 and TP53 transcription factors.
A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes.
Taylor et al., Basel, Switzerland. In Cancer Cell, Jan 2016
Additionally, simultaneous inactivation of RBP-Jκ and p53 induces primitive neuroectodermal-like tumors in mice.
Factors affecting platinum sensitivity in cervical cancer.
Fukasawa et al., Tokyo, Japan. In Oncol Lett, Dec 2015
Each specimen was assessed for immunohistochemical expression of Ki-67, p53, B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), cleaved caspase-3, cyclooxygenase-2 (COX-2), and excision repair cross-complementation group 1 (ERCC1).
Systematic analysis of the p53-related microRNAs in breast cancer revealing their essential roles in the cell cycle.
Zhou et al., Changsha, China. In Oncol Lett, Dec 2015
UNASSIGNED: Numerous miRNAs have been found to be involved in the regulation of the p53 signaling pathway.
P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development.
Shi et al., Shanghai, China. In Cell Death Dis, Dec 2015
It has been shown that p53 has a critical role in the differentiation and functionality of various multipotent progenitor cells.
Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals.
González et al., Málaga, Spain. In Antioxidants (basel), 2014
The DNA alterations include UV radiation induced thymine-thymine dimers and loss of tumor suppressor gene p53.
LMO4 inhibits p53-mediated proliferative inhibition of breast cancer cells through interacting p53.
Shan et al., Shijiazhuang, China. In Life Sci, 2012
LMO4 is a direct target of p53 and inhibits p53-mediated proliferative inhibition of breast cancer cells through interacting p53
TAp73 depletion accelerates aging through metabolic dysregulation.
Mak et al., Leicester, United Kingdom. In Genes Dev, 2012
TAp73 affects mitochondrial respiration and ROS homeostasis, thus regulating aging
Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines.
Barrett et al., London, Canada. In Arch Otolaryngol Head Neck Surg, 2012
6 of 7 HNSCC cell lines were studied, the TP53 mutations, predicted to confer loss of function, were noted in all cell lines.
New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy.
Murray et al., Edmonton, Canada. In J Biomed Biotechnol, 2011
Dynamic behaviors of p53 and p21 in the DNA damage response and the gain-of-function properties of cancer-associated p53 mutations, are reviewed.
Alterations of the TP53 gene in gastric and esophageal carcinogenesis.
Silva et al., Bauru, Brazil. In J Biomed Biotechnol, 2011
This study highlights the participation of the main genetic alterations of the TP53 gene in esophageal and gastric carcinogenesis.
More papers using p53 antibodies
Probing the unknown in cancer of unknown primary: which way is the right way?
Stojadinovic Alexander et al., In Journal of Cancer, 2009
... sections were double imunostained for SMA and p53 (clone: D07, Dako, Carpinteria, CA, USA) or ...
The CDK4-pRB-E2F1 pathway controls insulin secretion
Van de Casteele Mark et al., In Diabetes, 2008
... E2F-1-induced p53-independent apoptosis in transgenic mice ...
Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients
Richardson Andrea L et al., In Breast Cancer Research : BCR, 2008
... and CK19 (RCK108 antibody, Dako) as well as for EGFR (EGFR pharmDX kit, Dako) and p53 (DO-7 antibody, Dako).
Genomic interactions: chromatin loops and gene meeting points in transcriptional regulation.
Maedler Kathrin, In PLoS ONE, 2008
... Trp53, cdk2, p38 and JNK siRNA constructs were purchased from Applied Biosciences, mouse p53 vector was obtained from Origene (MC205636), and p53-luciferase reporter ...
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury
Courtneidge Sara A. et al., In The Journal of Cell Biology, 2008
... α-actin, and CD31 (Sigma-Aldrich); PKC-ε, PDGF-Rα, and glyceraldehyde 3-phosphate dehydrogenase (GAPDH; Cell Signaling Technology); and p53 clones sc-99 and sc-100 and isotypic IgG clone sc-2025 (Santa Cruz Biotechnology, Inc.) ...
A transcription co-factor integrates cell adhesion and motility with the p53 response.
Koepp Deanna, In PLoS ONE, 2008
... p53 antibody 1C12 (Cell Signaling Technology) and MDM2 antibody ...
The association between statins and cancer incidence in a veterans population
Aboussekhra Abdelilah, In PLoS ONE, 2007
... Anti-ATM-Ser1981 (Epitomics), anti-ATM (2C1) (Gene Tex), anti-γ-H2AX (Ser139) (Millipore), anti-LC3B (Abcam), anti-phospho-p53 (Ser15) (Cell Signaling Technology), anti-p53, anti-β-Actin, anti-Heme ...
HDAC6 inhibition enhances 17-AAG–mediated abrogation of Hsp90 chaperone function in human leukemia cells.
Rishi Arun, In PLoS ONE, 2007
... We used primary antibodies against p53 (Dako, Glostrup, Denmark); p21 ...
The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium.
Bauer Joseph Alan, In PLoS ONE, 2006
... Antibodies against NF-κB p65, IκB-α, phospho-IκB-α (Ser32), and p53 were obtained from Cell Signaling (Danvers, MA), as were ...
p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis
Bhat Manoj K et al., In Cell & Bioscience, 2006
... Phospho-p53 Ser46 antibody (rabbit polyclonal) was purchased from Cell Signaling Technology (Danvers, MA) ...
Where have all the interactions gone? Estimating the coverage of two-hybrid protein interaction maps.
Sommer Peter, In PLoS ONE, 2006
... Cellular factors (MHC-I, MHC-II, CD3ζ-chain, CD4, CD317, MurrI and p53) were PCR amplified from a human PCR-ready PBMC cDNA (Spring Bioscience) and ligated into pECFP-C1 ...
Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells
Park Maiyon et al., In Molecular Cancer, 2006
... Other antibodies were purchased from commercial sources: rabbit polyclonal antibodies against P53 (Cell Signaling) and Phospho-P53 (Cell Signaling); ...
Bipolar genome reductional division of human near-senescent, polyploid fibroblast cells
Ohshima Susumu, In Oxidative Medicine and Cellular Longevity, 2006
... DM1A, 1 : 500 dilution, Sigma, T9025), rabbit anticentrin-2 (N-17, 1 : 800 dilution, Santa Cruz Biotechnology, SC-27793-R), mouse anti-p53 (clone DO-7, 1 : 100 dilution, Santa Cruz Biotechnology, SC-47698), mouse anti-p53 phosphorylated ...
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
Navarro Alfons, In PLoS ONE, 2006
... phospho-Jak2-Y1007/1008, phospho-GSK3α/β-S9/21, and p85 as well as rabbit or mouse monoclonal antibody against phospho-STAT5-Y694 or p53 (1C12), respectively, were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency
Whitehouse Adrian et al., In The EMBO Journal, 2006
... ORF59- (Autogen Bioclear), p53- (Pharmagen Inc), GFP- (BD Biosciences) FLAG-, β-actin-, SC-35- (Sigma) ...
Some comments on frequently used multiple endpoint adjustment methods in clinical trials.
Blagosklonny Mikhail V., In PLoS ONE, 2006
... SPC-p53(273H) transgenic and p53 knockout mice ...
Siva is an apoptosis-selective p53 target gene important for neuronal cell death
Prasad Kanteti V.S. et al., In Journal of Carcinogenesis, 2006
... cytochrome C oxidase IV (COX IV) (Molecular Probes, Invitrogen, 1:1,000); Bax 6A7 (BD Biosciences); mouse monoclonal p53 (Cell Signaling Technologies, 1:1,000); rabbit IgG-HRP ...
Differential effects of selected natural compounds with anti-inflammatory activity on the glucocorticoid receptor and NF-kappaB in HeLa cells
Das Bhudev C et al., In Molecular Cancer, 2005
... Polyclonal antibodies to AP-1, hTERT, Caspase-3, Rb, PARP-1 and Monoclonal antibodies to HPV16E6/18E6, HPV16E7, HPV18E7, p53 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Association between polymorphisms of DNA repair gene XRCC1 and DNA damage in asbestos-exposed workers.
Kane Agnes B. et al., In Environmental Health Perspectives, 2005
... We immunoblotted with antibodies against XRCC1 (Abcam), phosphorylated p53 (Ser15; Cell Signaling Technology, Danvers, MA), p53 ...
Genetic variants in epigenetic genes and breast cancer risk
Nevanlinna Heli et al., In Breast Cancer Research : BCR, 2005
... Immunohistochemical staining of TMA slides was performed with a mouse monoclonal anti-human p53-antibody (DO-7, DAKO) (Table ...
Automated tracking of gene expression in individual cells and cell compartments
Sée V et al., In Cell Death & Disease, 2005
... Mouse anti-p65 (sc-8008) and mouse anti-p53 (sc-263) antibodies were from Santa Cruz Biotechnology Inc ...
TOR signaling in growth and metabolism
Barredo Julio C et al., In Molecular Cancer, 2005
... Primary antibodies against p21, p27, and p53 were purchased from Santa Cruz Biotechnology, Inc ...
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
Maitra Anirban et al., In Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2005
... (Cell Signaling Technology, Beverly, MA, dilution 1:100), and anti-p53 (Santa Cruz Biotechnology, Santa Cruz, CA, dilution ...
Treatment of hormone-refractory breast cancer: apoptosis and regression of human tumors implanted in mice.
El-Rifai Wael, In PLoS ONE, 2005
... The p53- and survivin-targeted small interfering RNA (siRNA) were purchased from Santa Cruz Biotechnology.
Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells
Saikumar Pothana et al., In Oncogene, 2005
... Bip rat monoclonal and Chop and Lamin B rabbit polyclonals, p53 mouse monoclonal antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Combined Adjuvant Cisplating and Ifosfamide Chemotherapy and Radiotherapy for Malignant Mixed Mullerian Tumors of the Uterus
Diudea Dana et al., In World Journal of Surgical Oncology, 2005
... P53Clone DO-71/50Dako ...
Relationship of patients' age to histopathological features of breast tumours in BRCA1, BRCA2, and in mutation negative breast cancer families
Nevanlinna Heli et al., In Breast Cancer Research : BCR, 2004
... All the TMA slides were stained using routine methodology with p53 antibodies (1:300; Dako, Copenhagen, Denmark; described previously ...
p53 Translocation to Mitochondria Precedes Its Nuclear Translocation and Targets Mitochondrial Oxidative Defense Protein-Manganese Superoxide Dismutase
St Clair Daret K. et al., In Oncogene, 2004
... Cayman Chemical (Ann Arbor, MI), rabbit poly-clonal anti-Polγ antibody from Pierce Biotechnology (Rockford, IL), Monoclonal p53 antibody (DO-1) from Santa Cruz Biotechnology (Santa Cruz, CA), poly(rA).oligo(dT)
Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background
Bröcker Eva-B. et al., In Journal of Skin Cancer, 2004
... ], and p53 (Dako, Denmark) [ ...
Protein acetylation regulates both PU.1 transactivation and Ig kappa 3’ enhancer activity.
Raab-Traub Nancy, In PLoS Pathogens, 2004
... Mouse monoclonal antibody reactive to p53 (DO-1) and GFP (F56-BA1) were purchased from Santa Cruz Biotechnology, Inc ...
Co-stimulation of human breast cancer cells with transforming growth factor-beta and tenasicin-c enhances matrix metalloproteinase-9 expression and cancer cell invasion
Stojadinovic Alexander et al., In Journal of Cancer, 2003
... To identify cells with malignancy-associated alterations, sections were double immunostained for p53 (clone: D07, Dako, Carpinteria, CA) and smooth ...
Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation, and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells
Jung Sung Hoo et al., In Journal of Breast Cancer, 2003
... Antibodies against PTEN and p53 were purchased from Santa Cruz Biotechnology (Santa Cruz, USA) ...
Electromagnetic fields around silver nanoparticles and dimers
Luo Xiangang et al., In International Journal of Nanomedicine, 2003
... A mouse monoclonal p53 antibody raised against full-length p53 of human origin was purchased from Santa Cruz Biotechnology (Santa Cruz, CA).
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
Ouellette Michel M., In PLoS ONE, 2003
... , p53, and Ub(P4D1) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells.
Biggins Sue, In PLoS Genetics, 2003
... Briefly, the targeting constructs pAAV-CDK2 and pSEPT-p53 [58] were packaged into infectious rAAV subsequently used to generate transgenic clones ...
Cancer Gene Census, Cancer Genome Project Wellcome Trust Sanger Institute
Jonkers Jos et al., In BMC Cancer, 2003
... 1:50 (Neomarkers); progesterone receptor clone PR-1 titre 1:400 (Immunologic), c-erbB-2 clone SP3, titre 1:25 (Neomarkers); TP53 clone D0-7, titre 1:8000 (Dako).
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
Yook Jong In et al., In The Journal of Cell Biology, 2003
... siRNA duplexes directed against human p53 as well as scrambled controls were obtained from Santa Cruz Biotechnology, Inc ...
Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling
Wong Nai Sum, In PLoS ONE, 2002
... The anti-p53 was purchased from Oncogene (Merck Ltd., Budapest, Hungary) ...
Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry
Manié S N et al., In Cell Death & Disease, 2002
... en Yvelines, France), anti-p62 (SQSTM1, Enzo, Villeurbane, France), anti-LC3 (51–11, MBL International Corporation, Nanterre, France), anti-p53 (D0–7, DAKO), anti-Beclin (E-8, Santa-Cruz, Le ...
Relationship between HER2 status and proliferation rate in breast cancer assessed by immunohistochemistry, fluorescence in situ hybridisation and standardised AgNOR analysis
Ashankyty Ibraheem M. et al., In Pathology Research International, 2002
... Primary antibodies were incubated for 8 hours in a humidity chamber using the following dilutions: p53 (clone DO-7, titer 1 : 50, Dako, Denmark), HER-2/neu (titer 1 : 50, ...
p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion
Mihatsch Michael J. et al., In Nephrology Dialysis Transplantation, 2002
... Human p531:251Epitomics, Burlingame, CA, USA ...
The non-obese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse
Jeremias Irmela et al., In Cell Communication and Signaling : CCS, 2001
... For Western Blot analysis, the following antibodies were used: anti NFκBp65 and anti p53 from Santa Cruz Biotechnology Inc ...
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
Sriplung Hutcha et al., In ISRN Oncology, 2001
... were incubated overnight at 4°C with 1 : 250 and 1 : 40 dilutions of the monoclonal antibody of p53 (DO-7, DAKO, Glostrup, Denmark) and P-gp ...
A role for p53 in maintaining and establishing the quiescence growth arrest in human cells
Park Yoon Jeong et al., In International Journal of Nanomedicine, 2001
... Rabbit polyclonal antibodies specific for p53 and Ser15 phosphorylated p53 were obtained from Cell Signaling Technology (Beverly, MA) ...
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
Harris Curtis C. et al., In The Journal of Cell Biology, 2001
... The antibodies used were as follows: Anti-p53: monoclonals DO-1 (Santa Cruz Biotechnology, Inc.); rabbit polyclonal CM1 ...
Apoptosis as an independent prognostic indicator in squamous cell carcinoma of the esophagus
Hirakawa Kosei et al., In Journal of Experimental & Clinical Cancer Research : CR, 2000
... antibodies, mouse monoclonal anti-Cx26 (Zymed Laboratories, San Francisco, CA, working dilution 1:500) and mouse monoclonal P53 antibodies (DAKO, Carpinteria, CA, ready to ...
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
Nie Jing et al., In International Journal of Biological Sciences, 2000
... and cleaved caspase-3 were purchased from Cell Signaling (Danvers, MA); Antibodies against Notch-1, Hes-1 and p53 were purchased from Santa Cruz Biotechnology Inc (Santa Cruz, CA) ...
Role of palmitoyl-protein thioesterase in cell death: Implications for infantile neuronal ceroid lipofuscinosis
Wu Yu-Jen et al., In Marine Drugs, 2000
... Antibodies against cytochrome C and p53 were from Epitomics (Burlingame, CA, USA) ...
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
Slack Ruth S. et al., In The Journal of Cell Biology, 2000
... p53-deficient transgenic mice were obtained from ...
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation
Schmidt M et al., In British Journal of Cancer, 2000
... , anti-A1/Bfl-1, anti-Bax, and anti-p53 antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium
Prolla Tomas A et al., In BMC Genomics, 1999
... Expression of p53-related genes in wild type and transgenic GPX4 and MnSOD mice ...
The p53 tumour-supressor gene integrates numerous signals that control cell life and death. As when a highly connected node in the internet breaks down the disruption of p53 has severe consequences
Tecimer Tulay et al., In Diagnostic Pathology, 1999
... P53 was incubated with monoclonal mouse anti-human (Dako Cytomatin En Vision Clone ...
mdm-2 gene amplification in 3T3-L1 preadipocytes
Berberich Steven J. et al., In Aging (Albany NY), 1998
... A phosphorylation-specific p53 polyclonal antibody kit (Cell Signaling Technology, Inc.) was utilized ...
Mitochondrial depolarization is not required for neuronal apoptosis
Giese Alf et al., In Neuro-Oncology, 1998
... p53 was detected by the antibody DO-7 (BD Pharmingen) or the phosphorylation-sensitive antibody 16G8 recognizing p53 protein phosphorylated at Ser15 (Cell Signaling Technology, Inc.) ...
Novel indications for BRCA1 screening using individual clinical and morphological features
Nevanlinna Heli et al., In Breast Cancer Research, 1998
... antibody (NCL-CB11, 1:400) were purchased from Novocastra (Newcastle upon Tyne, UK), and PR (1:250) and p53 antibodies (1:100) were from Dako (Copenhagen, Denmark) ...
Simple Screening Method for Autoantigen Proteins Using the N-Terminal Biotinylated Protein Library Produced by Wheat Cell-Free Synthesis
Sawasaki Tatsuya et al., In Journal of Proteome Research, 1997
... Anti-p53 monoclonal antibody (D01) was purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Correlation between p53 mutation and Cyclin D1 amplification in head and neck squamous cell carcinoma
Ranganathan Kannan et al., In Journal of Oral and Maxillofacial Pathology : JOMFP, 1996
... cell carcinoma (OSCC) and 10 normal mucosa were used and the primary antibodies used were p53 (DAKO-DO7) and Cyclin D1 Mouse ...
HA95 and LAP2β mediate a novel chromatin–nuclear envelope interaction implicated in initiation of DNA replication
Collas Philippe et al., In The Journal of Cell Biology, 1996
... Anti-GST, anti-Cdc6 (H-304 and clone 180.2), anti-Orc2, goat anti–lamin B antibodies, and anti-p53 antibodies were from Santa Cruz Biotechnology, Inc ...
Spliced exons of adenovirus late RNAs colocalize with snRNP in a specific nuclear domain.
Jung Jae U., In PLoS Pathogens, 1995
... SRp20, Y14, and Magoh (Santa Cruz Biotech), p53 (Pharmagen Inc), GFP mAb and GFP pAb (BD Biosciences) and Myc, SC-35, B-actin ...
Growth pattern and p53 overexpression in patients with early gastric cancer.
Catalano Giuseppina et al., In BMC Cancer, 1994
... reduce nonspecific staining and incubated at room temperature for 1 hour with a murine monoclonal antibody for p53 (clone DAKO D07, Copenhagen, Denmark; dilution ...
Raf-1 Antagonizes Erythroid Differentiation by Restraining Caspase Activation
Baccarini Manuela et al., In The Journal of Experimental Medicine, 1994
... Fetal liver– and bone marrow–derived cells and immortal mouse erythroblasts (I/11, p53-deficient; references 10 and 11) were expanded and maintained in serum-free erythroid medium (StemPro34™ plus nutrient supplement; Life Technologies) supplemented with 2 units/ml human ...
Isolation of Epstein-Barr virus (EBV)-negative cell clones from the EBV-positive Burkitt's lymphoma (BL) line Akata: malignant phenotypes of BL cells are dependent on EBV.
Sugden Bill, In PLoS Pathogens, 1993
... Mouse anti-Elongin C (BD Transduction Laboratory), mouse anti-Elongin B (BioLegend), mouse anti-GAPDH (Ambion), monoclonal mouse anti-p53 (Ab-6) (Merck), mouse anti-MDM2 (Ab-3) (Merck) ...
p21-containing cyclin kinases exist in both active and inactive states
Burczynski F et al., In British Journal of Cancer, 1993
... and p53 antibodies were purchased from Santa Cruz Biotechnology Inc ...
The limit fold change model: a practical approach for selecting differentially expressed genes from microarray data
Hubank Michael et al., In Genome Biology, 1991
... Western blots were probed against total p53 (Santa Cruz Biotechnology Inc ...
NADH-dependent microsomal interaction with ferric complexes and production of reactive oxygen intermediates.
Xu Aimin, In PLoS ONE, 1988
Polyclonal antibody for the detection of acetylated p53 was obtained from Abcam ...
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