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Actin related protein 2/3 complex, subunit 1B, 41kDa

p41-Arc, ARPC1B
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: Actin, Arp2, CAN, Actin-Related Protein 3, p21
Papers on p41-Arc
Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
Way et al., Gif-sur-Yvette, France. In Nat Cell Biol, Jan 2016
We found that Arp2/3 complexes containing ARPC1B and ARPC5L are significantly better at promoting actin assembly than those with ARPC1A and ARPC5, both in cells and in vitro.
The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1).
Kim et al., Seoul, South Korea. In J Biol Chem, Sep 2015
Consistently, PAK1 mediates phosphorylation and modulation of the activity of p41-Arc, one of its plasma membrane substrate, in a fashion that requires PI3K and CKIP-1.
Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC).
Zain et al., Kuala Lumpur, Malaysia. In Eur Arch Otorhinolaryngol, Aug 2015
UNASSIGNED: Caveolin-1 (Cav-1) and Actin-Related Protein 2/3 Complex, Subunit 1B (ARPC1B) have been implicated in various human cancers, yet its role in tumorigenesis remains controversial.
Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation.
Balasinor et al., Mumbai, India. In Mol Cell Endocrinol, Apr 2015
This was accompanied by reduction in intratesticular testosterone levels and increase in intratesticular estrogen along with deregulation of genes involved in cytoskeleton remodeling (Arpc1b, Evl and Capg) and endocytosis (Picalm, Eea1 and Stx5a).
The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway.
Doublet et al., Mobile, United States. In Mbio, 2014
LegK2 phosphorylates the ARPC1B and ARP3 subunits of the ARP2/3 complex.
Identifying gene expression profile of spinal cord injury in rat by bioinformatics strategy.
Cheng et al., Shanghai, China. In Mol Biol Rep, 2014
Furthermore, the up-regulated genes (Arpc1b, CD74 and Brd2) significantly mapped to the target genes of transcription factors.
Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis.
Ichinose et al., Wakayama, Japan. In Gastric Cancer, 2013
Examined loci were the promoter CpG islands of six genes (FLNc, HAND1, THBD, p41ARC, HRASLS, and LOX) and the CpG sites of non-coding repetitive elements (Alu and Satα) that are reportedly altered by H. pylori infection.
Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration.
Kallioniemi et al., Tampere, Finland. In Anticancer Res, 2013
RESULTS: ARPC3 and ARPC4 were the most highly expressed complex members, while ARPC1B and ARPC2 were expressed at low levels.
Changes associated with lenalidomide treatment in the gene expression profiles of patients with del(5q).
Jonasova et al., Praha, Czech Republic. In Clin Lymphoma Myeloma Leuk, 2012
In contrast, we found that increased expression of the ARPC1B gene may have a negative impact on the stability of patient remission.
p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb.
Shin et al., Ch'ŏnan, South Korea. In Exp Mol Med, 2011
p41-Arc activates a senescence program in p53- and Rb-independent ways.
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.
Kumar et al., Washington, D.C., United States. In J Cell Biol, 2010
Arpc1b is both a physiological activator and substrate of Aurora A kinase and these interactions help to maintain mitotic integrity in mammalian cells.
Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis.
Song et al., Seoul, South Korea. In Cancer Sci, 2010
We investigated methylation profiles of p16, LOX, HAND1, THBD, p41ARC, and APC along multistep gastric carcinogenesis and determined their association with Helicobacter pylori infection.
Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches.
Takai et al., Tokyo, Japan. In Int J Cancer, 2010
We identified 8 methylated genes (ARPC1B, DNAH9, FLRT2, G0S2, IRS2, PKP1, SPOCK1 and UCHL1) previously unreported in NSCLC.
Array comparative genomic hybridization, expression array, and protein analysis of critical regions on chromosome arms 1q, 7q, and 8p in adenocarcinomas of the gastroesophageal junction.
van Marion et al., Rotterdam, Netherlands. In Cancer Genet Cytogenet, 2009
Based on a mRNA overexpression criterion, 11 genes were selected: ELF3 and SLC45A3 on 1q; CLDN12, CDK6, SMURF1, ARPC1B, ZKSCAN1, MCM7, and COPS6 on 7q; and FDFT1 and CTSB on 8p.
Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines.
Valvassori et al., Bologna, Italy. In Int J Oncol, 2008
In our study we identified several differentially expressed genes (GADD45alpha, VCP, DHX9, survivin, alpha-catulin, ARPC1B) related to growth arrest and apoptosis.
Arpc1b gene is a candidate prediction marker for choroidal malignant melanomas sensitive to radiotherapy.
Seki et al., Chiba, Japan. In Invest Ophthalmol Vis Sci, 2006
From the analysis of the different radio-sensitivity cancer cell lines, the Arpc1b gene was selected as a prediction marker gene for sensitivity of CMM to radiotherapy.
p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.
Kumar et al., Houston, United States. In Embo Rep, 2004
Phosphorylation of p41-ARC by p21-activated kinase 1.
Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers.
Ushijima et al., Tokyo, Japan. In Int J Cancer, 2002
INSIG1 and p41 Arp2/3 complex (p41-Arc)reduced expression might be involved in gastric cancer development or progression
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