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Cyclin-dependent kinase 5, regulatory subunit 2

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p35, Cyclin-Dependent Kinase 5, PCNA, CAN, p35
Papers on p39
Application of multiplexing technology to the analysis of the intrathecally released immunoglobulins against B. burgdorferi antigens in neuroborreliosis.
Lewczuk et al., Białystok, Poland. In Immunol Lett, Nov 2015
IgG-ASI against either VlsE, p100, p58, p39, p18, or OspC, and none of these patients showed positive OspA-IgG-ASI.
AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis.
Kang et al., Tianjin, China. In Cancer Lett, Aug 2015
AC1MMYR2 attenuated CDK5 activity by functional targeting CDK5RAP1, CDK5 activator p39 and target p-FAK(ser732).
Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation.
Bach et al., College Station, United States. In Chem Biol, May 2015
CDK5 is activated through its association with the activators, p35 and p39, rather than by cyclins.
The inhibition of Cdk5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats.
Xu et al., Suzhou, China. In Neuroscience, May 2015
We further showed that the levels of Cdk5 activators p35 and p39 decreased after HI injury, while p25, which is converted from p35 and has a higher activator activity on Cdk5, increased markedly after HI injury.
Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders.
Masliah et al., San Diego, United States. In Curr Hiv Res, 2014
CDK5 is activated by binding to its regulatory subunit, p35 or p39.
Anti-diabetes drug pioglitazone ameliorates synaptic defects in AD transgenic mice by inhibiting cyclin-dependent kinase5 activity.
Li et al., Nanjing, China. In Plos One, 2014
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the neuron specific activators p35/p39 and plays many important roles in neuronal development.
Deregulated Cdk5 activity is involved in inducing Alzheimer's disease.
Pant et al., Bethesda, United States. In Arch Med Res, 2012
Cdk5 gets activated by its neuronal activators p35 and p39.
Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5.
Arif, Cleveland, United States. In Biochem Pharmacol, 2012
Also atypical is the activation of Cdk5 by binding of a non-cyclin activator protein, namely, the Cdk5 regulatory proteins Cdk5R1 (p35), truncated Cdk5R1 (p25), or Cdk5R2 (p39).
Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma.
Hu et al., Taiwan. In Med Oncol, 2011
Hepatocellular carcinoma patients with lower p39 expression had poorer overall survival rate than that with high expression.
Cdk5: multitasking between physiological and pathological conditions.
Agostinho et al., Coimbra, Portugal. In Prog Neurobiol, 2011
This kinase is present mainly in post-mitotic neurons and its activity is tightly regulated by the interaction with the specific activators, p35 and p39.
Cyclin-dependent kinases in brain development and disease.
Tsai et al., Cambridge, United States. In Annu Rev Cell Dev Biol, 2010
Two related proteins, p35 and p39, activate Cdk5 upon direct binding.
Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.
Hisanaga et al., Hachiōji, Japan. In Biochemistry, 2010
both proteasomal degradation and calpain cleavage of p35 and p39 are stimulated by membrane association, which is in turn mediated via myristoylation of their p10 regions.
Control elements in the neighboring ATPase gene influence spatiotemporal expression of the human agouti-related protein.
Argyropoulos et al., Baton Rouge, United States. In J Mol Biol, 2009
two adjacent enhancers inside the first intron of the neighboring (1.4 kb downstream) ATPase gene (ATP6V0D1) modulate the human AgRP promoter with profound spatiotemporal variation
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Turck et al., São Paulo, Brazil. In Eur Arch Psychiatry Clin Neurosci, 2009
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia
Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.
Hisanaga et al., Tokyo, Japan. In J Neurochem, 2008
The differential nuclear accumulation of p39 and p35 suggests their segregated functions, p35-Cdk5 in the cytoplasm and p39-Cdk5 in the nucleus.
Transcriptional regulation of cortical neuron migration by POU domain factors.
Rosenfeld et al., San Diego, United States. In Science, 2002
Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons, with Brn-1(-/-)/Brn-2(-/-) mice exhibiting cortical inversion.
Identification of maize histone deacetylase HD2 as an acidic nucleolar phosphoprotein.
Loidl et al., Innsbruck, Austria. In Science, 1997
Antibodies against recombinant HD2-p39 immunoprecipitated the native enzyme complex, which was composed of phosphorylated p39 subunits.
fos-associated cellular p39 is related to nuclear transcription factor AP-1.
Verma et al., San Diego, United States. In Cell, 1988
We show that one of the fos-associated proteins, p39, is immunologically and structurally related to nuclear factor AP-1.
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes.
Karin et al., San Diego, United States. In Cell, 1988
One of these, FAP p39, is structurally identical to c-Jun/AP-1.
Fos-associated protein p39 is the product of the jun proto-oncogene.
Franza et al., Nutley, United States. In Science, 1988
A combination of structural and immunological comparisons has identified the Fos-associated protein (p39) as the protein product of the jun proto-oncogene (c-Jun).
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