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Mitogen-activated protein kinase 11

p38beta, SAPK2, Mitogen-Activated Protein Kinase 11
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p38, MAPK, Mitogen-Activated Protein Kinase 3, JNK, p38delta
Papers on p38beta
MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth.
Mongiat et al., Italy. In Oncotarget, Jan 2016
In response to VEGF-A165, we show that MULTIMERIN2 impairs the phosphorylation of VEGFR2 at both Y1175 and Y1214 residues, halts SAPK2/p38 activation and negatively affects endothelial cell motility.
Mechanism of interferon-gamma production by monocytes stimulated with myeloperoxidase and neutrophil extracellular traps.
Yamaguchi et al., Kumamoto, Japan. In Blood Cells Mol Dis, Aug 2015
Neither a combined p38alpha and p38beta inhibitor (SB203580) nor an extracellular signal-regulated kinase inhibitor (PD98059) suppressed IFN-gamma production.
Mechanism of interleukin-13 production by granulocyte-macrophage colony-stimulating factor-dependent macrophages via protease-activated receptor-2.
Yamaguchi et al., Kumamoto, Japan. In Blood Cells Mol Dis, Jun 2015
Neither SB203580 (a p38alpha/p38beta inhibitor) nor BIRB796 (a p38gamma/p38delta inhibitor) affected IL-13 production, while TMB-8 (a calcium chelator) diminished IL-13 production.
TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α.
Mignatti et al., Philadelphia, United States. In Mol Cancer Res, 2012
Thus, in endothelial cells p38alpha mediates apoptotic signaling, whereas p38beta and p38gamma transduce survival signaling
Regulation of sodium iodide symporter gene expression by Rac1/p38β mitogen-activated protein kinase signaling pathway in MCF-7 breast cancer cells.
Brent et al., Los Angeles, United States. In J Biol Chem, 2012
Overexpression of p38beta or Rac1 significantly enhanced (1.9- and 3.9-fold, respectively), the tRA-stimulated NIS expression in MCF-7 cells.
A rice orthologue of the ABA receptor, OsPYL/RCAR5, is a positive regulator of the ABA signal transduction pathway in seed germination and early seedling growth.
Kim et al., Suwŏn, South Korea. In J Exp Bot, 2012
A rice ABA signalling unit composed of OsPYL/RCAR5, OsPP2C30, SAPK2, and OREB1 for ABA-dependent gene regulation was further identified, via interaction assays and a transient gene expression assay.
Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma.
Gera et al., Los Angeles, United States. In Mol Cancer Ther, 2011
The activation of this salvage pathway is dependent on SAPK2/p38-mediated activation of IRES-dependent initiation of the cyclin D1 and c-MYC mRNAs, resulting in the maintenance of their protein expression levels.
Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation.
Han et al., Xiamen, China. In J Biol Chem, 2011
Cell growth is influenced by environmental stress.
p38α and p38β mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons.
Dechant et al., Innsbruck, Austria. In J Neurosci, 2011
The neurotransmitter switch is impaired in neurons isolated from p38beta-deficient mice; loss of cells expressing cholinergic properties is observed in the stellate ganglion of mature mice deficient in the p38beta isoform.
Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development.
Nebreda et al., Madrid, Spain. In Proc Natl Acad Sci U S A, 2011
Results identify essential roles for p38alpha and p38beta during development and suggest that some specific functions may be explained by differences in expression patterns.
Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate.
Iversen et al., Århus, Denmark. In Acta Derm Venereol, 2011
Demonstrate roles of the p38alpha/beta/delta isoforms in the regulation of 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation.
Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A.
Mackintosh et al., Sevilla, Spain. In Cell Biochem Biophys, 2010
Data shown suggest that calyculin A-induced phosphorylation of Ser473 was largely blocked by LY294002 and SB-203580 inhibitors, indicating that both PI3-kinase/TORC2-dependent and SAPK2/p38-dependent protein kinases contributed to phosphorylation of Ser473 in calyculin A-treated cells.
p38gamma mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation.
Loeser et al., Winston-Salem, United States. In Osteoarthritis Cartilage, 2010
RESULTS: Stimulation of chondrocytes with either IL-1beta or Fn-f led to enhanced phosphorylation of p38alpha and p38gamma, with little phosphorylation of p38beta or p38delta isoforms.
Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 3.
Aoki et al., Tokyo, Japan. In Bioorg Med Chem Lett, 2010
Among them, compound 4a, (S)-2-(4-fluorophenyl)-4-(1,2,3,5,6,8a-hexahydroindolizin-7-yl)-3-(pyridin-4-yl)-1H-pyrrole (R-132811), achieved the most promising results in various in vitro and in vivo tests including several rheumatoid arthritis models ((i) inhibition of p38alpha, p38beta, p38gamma, and p38delta MAP kinases: IC(50)=0.034,
p38 MAP-kinases pathway regulation, function and role in human diseases.
Rousseau et al., Dundee, United Kingdom. In Biochim Biophys Acta, 2007
There are four members of the p38MAPK family (p38alpha, p38beta, p38gamma and p38delta) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities and sensitivities to chemical inhibitors such as SB203580.
Genetic deficiency of p38alpha reveals its critical role in myoblast cell cycle exit: the p38alpha-JNK connection.
Muñoz-Cánoves et al., Barcelona, Spain. In Cell Cycle, 2007
However, the relative contribution of the four p38 MAP kinases (p38alpha, p38beta, p38gamma and p38delta) to this process was unknown.
Novel strategies for inhibition of the p38 MAPK pathway.
Lin et al., Beijing, China. In Trends Pharmacol Sci, 2007
The p38 subgroup of the mitogen-activated protein kinase superfamily has four isoforms: p38alpha, p38beta, p38delta and p38gamma.
MAP kinases and the control of nuclear events.
Gutkind et al., Bethesda, United States. In Oncogene, 2007
They include the extracellular signal-regulated protein kinases (ERK1 and ERK2); c-Jun N-terminal kinases (JNK1, JNK2, JNK3); p38s (p38alpha, p38beta, p38gamma, p38delta) and ERK5.
Dysregulation of the endothelial cellular response to oxidative stress in cancer.
Huot et al., Québec, Canada. In Mol Carcinog, 2006
In particular, the integrity of the endothelial layer in response to oxidative stress is tightly regulated by the balanced activation of the extracellular-signal regulated kinase (ERK) and the stress-activated protein kinase-2/p38 (SAPK2/p38) pathways.
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