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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Dicarbonyl/L-xylulose reductase

P34H, L-xylulose reductase, X-R, DCXR, dicarbonyl/L-xylulose reductase
The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: CAN, ACID, MEN, HAD, Thioredoxin
Papers on P34H
Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma.
Chen et al., Indianapolis, United States. In Cancer Genomics Proteomics, Dec 2015
A comprehensive approach to prioritize the biomarker candidates by category and rank revealed CD63, DDB1, TYMP, VDAC2, and DCXR as the top five biomarker candidates.
Modulating the regioselectivity of a Pasteurella multocida sialyltransferase for biocatalytic production of 3'- and 6'-sialyllactose.
Mikkelsen et al., Denmark. In Enzyme Microb Technol, Oct 2015
The mutation P34H led to a 980-fold increase in α-2,6-sialyltransferase activity (with cytidine-5'-monophospho-N-acetylneuraminic acid as donor), while its α-2,3-sialyltransferase activity was abolished.
Human DCXR - another 'moonlighting protein' involved in sugar metabolism, carbonyl detoxification, cell adhesion and male fertility?
Maser et al., Kiel, Germany. In Biol Rev Camb Philos Soc, Feb 2015
Dicarbonyl/L-xylulose reductase (DCXR; SDR20C1), a member of the short-chain dehydrogenase/reductase (SDR) superfamily catalyzes the reduction of α-dicarbonyl compounds and monosaccharides.
Dicarbonyl L-xylulose reductase (DCXR), a "moonlighting protein" in the bovine epididymis.
Sullivan et al., Québec, Canada. In Plos One, 2014
Dicarbonyl L-xylulose reductase (DCXR), a multifunctional protein involved in various enzymatic and protein interaction processes in different physiological systems, is one of the proteins added to spermatozoa in the epididymis.
Proteomic identification of target proteins in normal but nonfertilizing sperm.
Mandelbaum et al., Paris, France. In Fertil Steril, 2014
Twelve of these proteins were identified by mass spectrometry, and two may influence gametes interaction: laminin receptor LR67 and L-xylulose reductase (P34H).
Dicarbonyl/l-xylulose reductase (DCXR): The multifunctional pentosuria enzyme.
Ahnn et al., Seoul, South Korea. In Int J Biochem Cell Biol, 2013
Dicarbonyl/L-xylulose reductase (DCXR) is a highly conserved and phylogenetically widespread enzyme converting L-xylulose into xylitol.
(-)-Epigallocatechin-3-gallate, a potential inhibitor to human dicarbonyl/L-xylulose reductase.
Yu et al., Shanghai, China. In J Biochem, 2013
Dicarbonyl/l-xylulose reductase (DCXR), mainly catalysing the reduction of α-dicarbonyl compounds and l-xylulose, belongs to the short-chain dehydrogenase/reductase superfamily.
Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats.
Sriram et al., Morgantown, United States. In Am J Pathol, 2012
Olfactory neuroepithelial injury included loss of olfactory neurons that showed reduced expression of the 2,3-pentanedione-metabolizing enzyme, dicarbonyl/L-xylulose reductase, relative to sustentacular cells.
Analysis of Modification of Liver Proteome in Diabetic Rats by 2D Electrophoresis and MALDI-TOF-MS.
Ravikumar et al., Thanjāvūr, India. In Indian J Clin Biochem, 2012
Comparison of 2-DE protein distribution profiles among the livers from normal, alloxan-induced diabetic rats and alloxan-induced diabetic rats treated with C. dactylon leaves identified three proteins that were up-regulated in alloxan-induced diabetic rats i.e., nucleophosmin, l-xylulose reductase and carbonic anhydrase III which are known to be mainly involved in ribosome biogenesis, centrosome duplication, cell proliferation, tumor suppression, glucose metabolism, osmo-regulation, water-CO2 balance and acid-base balance.
Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria.
Motulsky et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2011
combined frequency of the two mutant DCXR alleles in 1,067 Ashkenazi Jewish controls was 0.0173, suggesting a pentosuria frequency of approximately one in 3,300 in this population
Gene expression in the epididymis of normal and vasectomized men: what can we learn about human sperm maturation?
Thimon et al., Québec, Canada. In J Androl, 2011
Three of the affected genes are particularly interesting because of their involvement in sperm biochemical remodeling during epididymal transit: dicarbonyl/l-xylulose reductase, Niemann-Pick disease, type C2, and cysteine-rich secretory protein 1.
Bioinformatic and biochemical characterization of DCXR and DHRS2/4 from Caenorhabditis elegans.
Maser et al., Kiel, Germany. In Chem Biol Interact, 2011
In order to characterize the human enzymes dicarbonyl/l-xylulose reductase (DCXR), and dehydrogenase/reductase members 2 and 4 (DHRS2, DHRS4) in terms of metabolism of xenobiotics, orthologues from the model organism Caenorhabditis elegans (C.
DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans.
Ahnn et al., Seoul, South Korea. In Febs Lett, 2011
Dicarbonyl/L-xylulose reductase (DCXR) converts l-xylulose into xylitol, and reduces various α-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification.
Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase.
El-Kabbani et al., Australia. In Cell Mol Life Sci, 2009
The action of human XR may be regulated by cellular redox conditions through reversible disulfide-bond formation and by S-cysteinylation.
Novel epididymal proteins as targets for the development of post-testicular male contraception.
Poutanen et al., Turku, Finland. In Reproduction, 2009
These proteins include CRISP1, SPAG11e, DEFB126, carbonyl reductase P34H, CD52, and GPR64.
Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl/L-xylulose reductase.
Nakagawa et al., Japan. In Ann N Y Acad Sci, 2008
DCXR trranfected into mice may function in the removal of renal alpha-dicarbonyl compounds under oxidative circumstances, but it is not sufficient to suppress acute renal fibrosis.
Dicarbonyl/L-xylulose reductase: a potential biomarker identified by laser-capture microdissection-micro serial analysis of gene expression of human prostate adenocarcinoma.
McDonnell et al., Houston, United States. In Cancer Epidemiol Biomarkers Prev, 2007
DCXR overexpression has the potential to be an additional useful biomarker for prostate cancer.
Expression of dicarbonyl/L-xylulose reductase (DCXR) in human skin and melanocytic lesions: morphological studies supporting cell adhesion function of DCXR.
Prieto et al., Houston, United States. In J Cutan Pathol, 2007
Decreased membranous expression of DCXR with altered subcellular localization appears to be associated with malignant progression of melanocytic lesions in human skin.
Role of exosomes in sperm maturation during the transit along the male reproductive tract.
Frenette et al., Canada. In Blood Cells Mol Dis, 2005
Finally, P25b, belonging to a family of sperm surface proteins (P26h/P34H) necessary for the binding to the surface of the egg, is also acquired through the interaction between epididymosomes and the male gamete.
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