Coupling of P2Y receptors to G proteins and other signaling pathways.
Columbia, United States. In Wiley Interdiscip Rev Membr Transp Signal, 2012
There are eight subtypes of P2Y receptors (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14), which activate intracellular signaling cascades to regulate a variety of cellular processes, including proliferation, differentiation, phagocytosis, secretion, nociception, cell adhesion, and cell migration.
Reduced bone turnover in mice lacking the P2Y13 receptor of ADP.
Sheffield, United Kingdom. In Mol Endocrinol, 2012
study to examine the role of P2Y13 receptor in bone homeostasis both in vivo and in vitro; deletion of the P2Y13 receptor leads to less trabecular bone in mice, by affecting both osteoblasts and osteoclasts
Altered lipoprotein metabolism in P2Y(13) knockout mice.
Rahway, United States. In Biochim Biophys Acta, 2010
experiments assess a role for the purinergic receptor P2Y(13) in the regulation of lipoprotein metabolism and demonstrate that modulating its activity could be of benefit to the treatment of dyslipidemia in people
P2Y13 receptor is critical for reverse cholesterol transport.
Toulouse, France. In Hepatology, 2010
study shows P2Y(13)-deficient mice exhibited a decrease in hepatic HDL cholesterol uptake, hepatic cholesterol content, and biliary cholesterol output, data indicate P2Y13 activity is involved in macrophage-to-feces reverse cholesterol transport