gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Membrane metallo-endopeptidase

p27, Cyclin-Dependent Kinase Inhibitor p27, CD10, Neprilysin, Kip1, p27Kip1
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, p21, CAN, V1a, p53
Papers using p27 antibodies
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
Vertessy Beata G., In PLoS ONE, 2009
... Immunoblotting using an anti-p27 antibody (Santa Cruz Biotechnology, Santa Cruz, CA) was ...
A case of primary small cell carcinoma of the breast
Bergkvist Leif et al., In Pathology Research International, 2006
... (Dako, clone Vim3B4, 1 : 600), calponin (Dako, clone CALP1, 1 : 600), p63 (Biocare Medical, clone BC4A4, 1 : 100), CD10 (Dako, clone 56C6, 1 : 50), and ...
Dose translation from animal to human studies revisited.
Batra Surinder K., In PLoS ONE, 2006
... antibodies for cytochrome c, Smac/DIABLO, Cyclin D1, Cyclin D2, Cyclin E, Cdk2, Cdk4, Cdk6, Cip1/p21, Kip1/p27 and the secondary antibodies, horseradish peroxidase-linked antimouse immunoglobulin G and anti-rabbit immunoglobulin G were obtained from Santa Cruz Biotechnology, Inc ...
Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differention
Wolf Gunter et al., In Arthritis Research & Therapy, 2006
... Dianova, Hamburg, Germany); anti-CML (Roche Diagnostics, Penzberg, Germany); anti-imidazolone (kindly provided by Toshumitsu Niwa, Japan); anti-p27Kip1 (Cell Signaling Technology, Inc., Danvers, MA, ...
more suppliers
Papers on p27
TIPE2, a negative regulator of TLR signaling, regulates p27 through IRF4-induced signaling.
Liu et al., Jinan, China. In Oncol Rep, Feb 2016
Our previous study identified TIPE2 as an inhibitor of gastric cancer cell growth; it promotes p27 expression, which leads to restored control of the cell cycle and cell division.
How to approach the many faces of endometrioid carcinoma.
Malpica, Houston, United States. In Mod Pathol, Jan 2016
Variants with distinct architectural and cytologic features include the following: (1) ECa with a villoglandular pattern (tumor with finger-like papillae lined by bland cells with a tendency for vascular/lymphatic invasion and lymph node metastasis once this pattern is seen within the myoinvasive component); (2) papillary ECa of intermediate grade (grade 2) (tumor that can be mistaken for serous carcinoma, as it contains papillae showing slightly irregular contours, moderately atypical cells, and it is associated with vascular/lymphatic invasion/lymph node metastasis, but with common association with mucinous metaplasia, MELF (microcystic, elongated, and fragmented) pattern of invasion, and wild p53 expression); (3) ECa with non-villous papillae (tumor containing pseudopapillae within glands with bland-appearing cytology commonly associated with abortive squamous differentiation and otherwise not different from usual ECa); (4) ECa with microglandular-like pattern (tumor that mimics microglandular hyperplasia of the cervix, often lacking the typical appearance of microglandular hyperplasia and showing Ki-67 index >10%, strong CD10 expression, and negative PAX-2, p63, and CD34); and (5) ECa with sex cord-like formations and hyalinization (tumor with interconnected cords and nests of bland epithelioid and spindled cells that merge with a typical component of low-grade ECa, usually associated with squamous differentiation and hyalinization).
Practical issues in uterine pathology from banal to bewildering: the remarkable spectrum of smooth muscle neoplasia.
Oliva, Boston, United States. In Mod Pathol, Jan 2016
It is important to highlight that CD10 is not a reliable marker in these differentials and should be used as a part of a panel of antibodies that also includes desmin and h-caldesmon.
Significance of androgen receptor and CD10 expression in cutaneous basal cell carcinoma and trichoepithelioma.
Ustun et al., Bolu, Turkey. In Oncol Lett, Dec 2015
The aim of the present study was to compare cluster of differentiation 10 (CD10) and androgen receptor (AR) expression patterns in BCC and TE, to investigate the predictive power of these proteins as markers of the two conditions.
Clinical impacts of a micropapillary pattern in lung adenocarcinoma: a review.
Yuan et al., Hangzhou, China. In Onco Targets Ther, Dec 2015
Molecular markers, including vimentin, napsin A, phosphorylated c-Met, cytoplasmic maspin, Notch-1, MUC1, and tumoral CD10, may have higher expression in MPPAC than other subtypes; conversely, markers such as MUC4 and surfactant apoprotein A have lower expression in MPPAC.
Expression of Skp2 and p27(kip1) proteins in hypopharyngeal squamous cell carcinoma and its clinical significance.
Wu et al., Quanzhou, China. In Oncol Lett, Dec 2015
UNASSIGNED: The aim of the present study was to determine the effect of S-phase kinase-associated protein 2 (Skp2) and cyclin-dependent kinase inhibitor p27(kinase-interacting protein 1) (p27(kip1)) protein expression on the occurrence and development of hypopharyngeal squamous cell carcinoma.
2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis.
Li et al., Zhenjiang, China. In Oncol Lett, Dec 2015
Additional mechanistic studies of two biomarkers, phosphatase and tensin homolog (PTEN) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)), in prostate cancer revealed that TFC treatment significantly upregulated the expression of PTEN and p27(Kip1).
Effect of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against human Merkel cell carcinoma MKL-1 cells.
Wu et al., Wuhan, China. In Oncol Lett, Dec 2015
Additional investigations revealed that NVP-BEZ235 attenuated PI3K/Akt/mTOR signaling and upregulated the levels of the cell cycle inhibitors p21 and p27.
Thyroid-like Follicular Carcinoma of the Kidney and Papillary Renal Cell Carcinoma with Thyroid-like Feature: Comparison of Two Cases and Literature Review.
Han et al., Jinan, China. In Ann Clin Lab Sci, Nov 2015
The former entirely consisted of thyroid-like follicular architecture and the tumor cells were diffusely positive for PAX-8, but negative for CK7, AMACR, and CD10.
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
Yaffe et al., Cambridge, United States. In Cancer Cell, Nov 2015
Like p53, hnRNPA0 is activated by a checkpoint kinase (MK2) and simultaneously controls both cell cycle checkpoints through distinct target mRNAs, but unlike p53, this is through the post-transcriptional stabilization of p27(Kip1) and Gadd45α mRNAs.
Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.
Sitnicka et al., Lund, Sweden. In Immunity, Sep 2015
Here we demonstrate that a Lin(-)CD34(+)CD38(+)CD123(-)CD45RA(+)CD7(+)CD10(+)CD127(-) population represents a NK lineage-restricted progenitor (NKP) in fetal development, umbilical cord blood, and adult tissues.
Renal angiomyolipoma with epithelial cysts: a rare entity and review of literature.
Zhang et al., Shaoxing, China. In Int J Clin Exp Pathol, 2014
Immunohistochemically, epithelial cysts were positive for CK but negative for ER, PR, CD10 and HMB-45; the subepithelial stroma and muscle-predominant AML were positive for ER, PR and HMB-45; the subepithelial stroma was negative for SMA, but muscle-predominant AML was positive for SMA.
Rb suppresses human cone-precursor-derived retinoblastoma tumours.
Cobrinik et al., New York City, United States. In Nature, 2014
Proliferation of Rb-depleted cones and retinoblastoma cells also depended on the Rb-related protein p107, SKP2, and a p27 downregulation associated with cone precursor maturation.
Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4.
Hsieh et al., New York City, United States. In Cancer Cell, 2014
Specifically, in MLL pro-B lymphoid, but not myeloid, leukemias, proteasome inhibition triggers apoptosis and cell cycle arrest involving activation cleavage of BID by caspase-8 and upregulation of p27, respectively.
Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.
Saido et al., Wako, Japan. In J Biol Chem, 2012
Cell surface expression of the major amyloid-beta peptide (Abeta)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.
Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.
Zuo et al., Memphis, United States. In J Neurosci, 2012
This study demonistrated that Sox2 or p27(Kip1) expression is an effective approach to inducing proliferation of neonatal auditory inner pillar cells.
Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids.
Rogatsky et al., New York City, United States. In Proc Natl Acad Sci U S A, 2012
Glucocorticoid repression of cytokine genes in primary macrophages is mediated by GR-interacting protein (GRIP)1, a transcriptional coregulator of the p160 family, which is recruited to p65-occupied NFkappaB-binding sites in conjunction with liganded GR.
[Variants of gastric carcinomas according to immunohistochemical mucins and CD10 expressions].
Korsakova et al., In Arkh Patol, 2012
Variants of gastric carcinomas according to immunohistochemical mucins and CD10 expressions
Overexpression of TRIM24 correlates with tumor progression in non-small cell lung cancer.
Wang et al., Shenyang, China. In Plos One, 2011
TRIM24 plays an important role in NSCLC progression
More papers using p27 antibodies
The role of receptor internalization in CD95 signaling
Almendro Vanessa et al., In Molecular Cancer, 2005
... anti-Bcl2, rabbit monoclonal anti-Bax, mouse monoclonal anti-cyclin D1, rabbit polyclonal antibodies against CDK4, CDK2, and p27 were from Santa Cruz Biotechnology and mouse monoclonal anti-tubulin ...
The structure and regulation of vinculin
Beaulieu Jean-François et al., In Journal of Cellular Physiology, 2005
... Temecula, CA), αV integrin (WB: 1/1,000) (AB1930, Millipore), p21 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), p27 (WB: 1/2,000) (Santa Cruz Biotechnology, Inc.), and cyclin D1 ...
Combined Adjuvant Cisplating and Ifosfamide Chemotherapy and Radiotherapy for Malignant Mixed Mullerian Tumors of the Uterus
Diudea Dana et al., In World Journal of Surgical Oncology, 2005
... P27SXS3G81/20Dako ...
Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration
Sakai Daisuke et al., In Arthritis Research & Therapy, 2004
... Polyclonal rabbit antibodies against rat phospho-MAPK (ERK1/2) (Thr202/Tyr204), p44/42 MAPkinase (ERK1/2), and p27 Kip1 were from Cell Signaling Technology (Beverly, MA, USA) ...
Tularemia in Denmark: identification of a Francisella tularensis subsp. holarctica strain by real-time PCR and high-resolution typing by multiple-locus variable-number tandem repeat analysis
Wakasa Haruki et al., In Virchows Archiv, 2004
... The panel of antibodies against CD 3 (Roche Diagnostics Corp., Ventana Medical Systems Inc.), CD 4, CD10 (Nichirei Corp., Tokyo Japan), CD 5, CD 8, CD 20, CD 30, CD 68 (all Dako, Carpinteria, Ca, USA), CD ...
Defective B cell tolerance checkpoints in systemic lupus erythematosus
Nussenzweig Michel C. et al., In The Journal of Experimental Medicine, 2003
... Enriched B cells were stained with anti–human CD10-PE (BD Biosciences) before separation with anti-PE ...
The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis
Kanthan Selliah Chandra et al., In World Journal of Surgical Oncology, 2002
... p27SX53G81/20Dako ...
High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature
Kim Kyoung-Mee et al., In Korean Journal of Pathology, 2002
... Immunohistochemical staining of mucin (MUC) 2, MUC5AC, MUC6, and CD10 was performed in three GA-FG cases using the BOND-MAX™ (Leica Microsystems, Wetzlar, Germany) ...
Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer
Watson Peter H et al., In Breast Cancer Research : BCR, 2001
... The antibodies used for immunoblotting and immunoprecipitation were Jab1 (1:3,000) (Sigma-Aldrich, Oakville, ON, Canada); p27 (1:200) (BD Biosciences, Mississauga, ON, Canada); Lamin ...
AP-1 in cell proliferation and survival
Oktay Kutluk et al., In Reproductive biology and endocrinology : RB&E, 2000
... selected from one ovary in each animal and stained for CDKIs p15, p16, p21 and p27 (Vector Laboratories, Burlingame, CA) ...
EGFR related peptides and their cognate receptors in breast cancer
Thomas Shaji et al., In International Journal of Breast Cancer, 2000
... Immunohistochemistry for CD10 (Diagnostic biosystems CD10 (56C6 clone), dilution ...
Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation.
Gromoll Joerg, In PLoS ONE, 1999
... Antibodies specific to IGFBP2 (M-18; sc-6002), IGFBP3 (M19; sc-6004), and p27 (C-19; sc-528) were procured from Santa Cruz Biotechnology Inc., CA and Anti-FKHR ...
Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death
Jessen Kristjan R. et al., In The Journal of Cell Biology, 1998
... mAb against cyclin D1, SMAD4, and pAbs against ErbB2, ErbB3, and p27 were purchased from Santa Cruz Biotechnology, Inc ...
Effect of aspirin on pharmacokinetics of antisense oligonucleotides in rats
Ahmad Aamir, In PLoS ONE, 1997
... (H-22), Cdk6 (C-21), Cyclin D1 (DCS-6), Cyclin E (HE12), Cdc25c (H6), E2F1 (KH95), p21 (C19), and p27 (C19) antibodies were from Santa Cruz Biotechnology, Inc ...
R: A language for data analysis and graphics
Staprans SI et al., In Retrovirology, 1995
... p27 with Qiagen HotStar Taq (Qiagen Inc., ...
share on facebooktweetadd +1mail to friends