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Rho GTPase activating protein 35

p190RhoGAP, GRF1, hGRF1
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RhoA, Rhodopsin, cdc25, Actin, Src
Papers using p190RhoGAP antibodies
Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5
Ivaska Johanna et al., In The Journal of Cell Biology, 2006
... AIIB2 [Developmental Studies Hybridoma Bank]; 12G10 [Abcam]; 9EG7 and MAB13 [BD]; MAB2252 [Millipore]), p120RasGAP and p190RhoGAP (BD), α-tubulin (Santa Cruz Biotechnology, Inc.), RhoA (Cell Signaling ...
Papers on p190RhoGAP
RasGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.
Santos et al., Salamanca, Spain. In J Cell Sci, Feb 2016
UNASSIGNED: Detailed immunocytochemical analyses comparing WT, GRF1 KO, GRF2 KO and GRF1/2 DKO mouse retinas uncovered the specific accumulation of misplaced, "ectopic" cone photoreceptor nuclei in the photoreceptor segment (PS) area of retinas from GRF2 KO and GRF1/2 DKO, but not of WT or GRF1 KO mice.
Williams et al., Lexington, United States. In Int J Sports Phys Ther, Nov 2015
Vertical loading rate (VLR), initial (GRF1) and peak vertical ground reaction force (GRF2) and lower leg joint coupling were calculated for each subject.
In Vitro and In Vivo Anti-Melanoma Effects of Pituranthos tortuosus Essential Oil Via Inhibition of FAK and Src Activities.
Rondé et al., Monastir, Tunisia. In J Cell Biochem, Nov 2015
Moreover, EO treatment decreased the expression level of p190RhoGAP, and Grb2, which impair cell migration and actin assembly.
Modulation of focal adhesion constituents and their down-stream events by EGF: On the cross-talk of integrins and growth factor receptors.
Tomakidi et al., Freiburg, Germany. In Biochim Biophys Acta, Oct 2015
Risen activity was seen as well for the analyzed distal down-stream events, p190RhoGAP and MAP kinases p42/44.
MVP-Associated Filamin A Mutations Affect FlnA-PTPN12 (PTP-PEST) Interactions.
Mérot et al., Nantes, France. In J Cardiovasc Dev Dis, Oct 2015
Interestingly, we showed that the FlnA mutations impair the activation status of two PTPN12 substrates, the focal adhesion associated kinase Src, and the RhoA specific activating protein p190RhoGAP.
Dynamic Changes in ANGUSTIFOLIA3 Complex Composition Reveal a Growth Regulatory Mechanism in the Maize Leaf.
De Jaeger et al., Gent, Belgium. In Plant Cell, Jun 2015
Indeed, GRF1, GRF6, GRF7, GRF12, GRF15, and GRF17 were significantly enriched in the division zone of the growing leaf, while GRF4 and GRF10 levels were comparable between division zone and expansion zone in the growing leaf.
Differential involvement of Ras-GRF1 and Ras-GRF2 in L-DOPA-induced dyskinesia.
Fasano et al., Ferrara, Italy. In Ann Clin Transl Neurol, Jun 2015
First, we investigated whether a prolonged l-DOPA treatment differentially affected ERK signaling in medium spiny neurons of the direct pathway (dMSNs) and in cholinergic aspiny interneurons (ChIs) and assessed the role of Ras-GRF1 in both subpopulations.
Concise review: Mechanotransduction via p190RhoGAP regulates a switch between cardiomyogenic and endothelial lineages in adult cardiac progenitors.
Levchenko et al., Seattle, United States. In Stem Cells, 2014
Furthermore, we found that these cues dynamically regulate the same molecular species, p190RhoGAP, which then acts through both RhoA-dependent and independent mechanisms.
Spatial regulation of tumor cell protrusions by RhoC.
Condeelis et al., United States. In Cell Adh Migr, 2013
Recent studies have shown that the signaling molecules including RhoC/p190RhoGEF/p190RhoGAP acts as a "molecular compass" in order to direct the spatial and temporal dynamics of the formation of these invasive and locomotory protrusions leading to efficient invasion.
Arg kinase signaling in dendrite and synapse stabilization pathways: memory, cocaine sensitivity, and stress.
Koleske et al., New Haven, United States. In Int J Biochem Cell Biol, 2013
Arg is activated downstream of integrin α3β1 receptors and it regulates the neuronal actin cytoskeleton by directly binding F-actin and via phosphorylation of substrates including p190RhoGAP and cortactin.
Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation.
Negishi et al., Kyoto, Japan. In Mol Biol Cell, 2012
role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation
Interplay between FAK, PKCδ, and p190RhoGAP in the regulation of endothelial barrier function.
Harrington et al., Providence, United States. In Microvasc Res, 2012
In this review, we will discuss the functions of three signaling molecules known to be involved in regulation of endothelial permeability: focal adhesion kinase (FAK), protein kinase C delta (PKCδ), and p190RhoGAP (p190).
β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.
Carlin et al., Cleveland, United States. In Mol Biol Cell, 2011
study demonstrates that the epidermal growth factor receptor (EGFR) cooperates with beta3 integrin to regulate p190RhoGAP activity in mammary gland epithelial cells
Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis.
Del Pozo et al., Madrid, Spain. In Cell, 2011
We show that caveolin-1 (Cav1) favors cell elongation in three-dimensional cultures and promotes Rho- and force-dependent contraction, matrix alignment, and microenvironment stiffening through regulation of p190RhoGAP.
p190 RhoGTPase-activating protein links the β1 integrin/caveolin-1 mechanosignaling complex to RhoA and actin remodeling.
Rizzo et al., Philadelphia, United States. In Arterioscler Thromb Vasc Biol, 2011
p190RhoGAP links integrins and caveolin-1/caveolae to RhoA in a mechanotransduction cascade that participates in endothelial adaptation to flow.
14-3-3 proteins fine-tune plant nutrient metabolism.
Schachtman et al., Yokohama, Japan. In Febs Lett, 2011
Work elucidates how 14-3-3s function as modulators of plant N and S metabolic pathways.
Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice.
Mócsai et al., Budapest, Hungary. In J Immunol, 2010
In a novel knockout mouse strain p190RhoGAP does not play a major, indispensable role in integrin signaling of neutrophils.
A mechanosensitive transcriptional mechanism that controls angiogenesis.
Ingber et al., Boston, United States. In Nature, 2009
Here we show that the Rho inhibitor, p190RhoGAP (also known as GRLF1), controls capillary network formation in vitro in human microvascular endothelial cells and retinal angiogenesis in vivo by modulating the balance of activities between two antagonistic transcription factors, TFII-I (also known as GTF2I) and GATA2, that govern gene expression of the VEGF receptor VEGFR2 (also known as KDR).
Regulation of phagocyte migration and recruitment by Src-family kinases.
Berton et al., Verona, Italy. In Cell Mol Life Sci, 2008
This same phenotype is found in cells with either a lack of SFK substrates and/or interacting proteins such as Pyk2/FAK, c-Cbl and p190RhoGAP.
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.
Reynolds et al., Nashville, United States. In Cell, 2007
Rac activation links diverse signaling systems to adherens junction assembly by controlling transient p190RhoGAP interactions with p120 and localized inhibition of Rho.
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