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Plakophilin 4

p0071, plakophilin-4, PKP4
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Armadillo, ARVCF, Rhodopsin, N-cadherin, CAN
Papers on p0071
A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells.
Zheng et al., Frederick, United States. In Nucleic Acids Res, Jan 2016
By global profiling of the SRSF3-regulated splicing events in human osteosarcoma U2OS cells, we found that SRSF3 regulates the expression of 60 genes including ERRFI1, ANXA1 and TGFB2, and 182 splicing events in 164 genes, including EP300, PUS3, CLINT1, PKP4, KIF23, CHK1, SMC2, CKLF, MAP4, MBNL1, MELK, DDX5, PABPC1, MAP4K4, Sp1 and SRSF1, which are primarily associated with cell proliferation or cell cycle.
p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas.
Leach et al., Baltimore, United States. In Dev Biol, Apr 2015
Although we observed reduced expression of adherens junction proteins E-cadherin, β-catenin, and α-catenin, p120 catenin family members p0071, ARVCF, and δ-catenin remained present at cell membranes in homozygous p120(f/f) pancreases, potentially providing stability for maintenance of epithelial integrity during development.
Striatins as plaque molecules of zonulae adhaerentes in simple epithelia, of tessellate junctions in stratified epithelia, of cardiac composite junctions and of various size classes of lateral adherens junctions in cultures of epithelia- and carcinoma-derived cells.
Rosin-Arbesfeld et al., Heidelberg, Germany. In Cell Tissue Res, Mar 2015
Striatins colocalize with E-cadherin or E-N-cadherin heterodimers and with the plaque proteins α- and β-catenin, p120 and p0071.
microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest.
Du et al., San Antonio, United States. In Rna Biol, 2014
Our comprehensive investigations on the dissection of the target genes of miR-449a revealed that 3 novel targets- MFAP4, PKP4 and TSEN15 -play important roles in mediating its differentiation-inducing function.
DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.
Reynolds et al., Nashville, United States. In Mol Biol Cell, 2014
Moreover, all DIPA family members (Ccdc85a, Ccdc85b/DIPA, and Ccdc85c) interact reciprocally with p120 family members (p120, δ-catenin, p0071, and ARVCF), suggesting significant functional overlap.
The cell-cell junctions of mammalian testes: I. The adhering junctions of the seminiferous epithelium represent special differentiation structures.
Franke et al., Heidelberg, Germany. In Cell Tissue Res, 2014
These junctions are based on N-cadherin anchored in cytoplasmic plaques, which in some subforms appear thick and dense but in other subforms contain only scarce and loosely arranged plaque structures formed by α- and β-catenin, proteins p120, p0071 and plakoglobin, together with a member of the striatin family and also, in rodents, the proteins ZO-1 and myozap.
Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.
Kim et al., Toronto, Canada. In Proc Natl Acad Sci U S A, 2014
We identified several known and putative interactions potentially relevant to cellular signaling pathways and confirmed interactions between full-length Scribble and the target proteins β-PIX, plakophilin-4, and guanylate cyclase soluble subunit α-2 using colocalization and coimmunoprecipitation experiments.
The armadillo protein p0071 is involved in Rab11-dependent recycling.
Hatzfeld et al., Halle, Germany. In J Cell Sci, 2014
p0071 is an intercellular junction protein of the p120 catenin family.
FMRP regulates actin filament organization via the armadillo protein p0071.
Hatzfeld et al., In Rna, 2013
Here, we show that FMRP regulates actin organization and neurite outgrowth via the armadillo protein p0071.
p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization.
Hatzfeld et al., Halle, Germany. In Biol Chem, 2013
P0071 is a member of a subfamily of armadillo proteins that also comprises p120-catenin (p120ctn), δ-catenin/NPRAP, ARVCF and the more distantly related plakophilins 1-3.
Functions of p120ctn in development and disease.
van Roy et al., Gent, Belgium. In Front Biosci, 2011
We will also elaborate on the structure and function of other members of the p120ctn subfamily: ARVCF, p0071 and delta-catenin.
Protein p0071, an armadillo plaque protein of adherens junctions, is predominantly expressed in distal renal tubules.
Hofmann et al., Mannheim, Germany. In Histochem Cell Biol, 2010
The structural and functional roles of p0071 are suggested by its preferential occurrence in distinct tubule segments, and its potential use as a cytodiagnostic cell type marker in renal pathology is discussed.
Targeting of p0071 to the midbody depends on KIF3.
Hatzfeld et al., Halle, Germany. In J Cell Sci, 2009
Data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Turck et al., São Paulo, Brazil. In Eur Arch Psychiatry Clin Neurosci, 2009
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Protein p0071, a major plaque protein of non-desmosomal adhering junctions, is a selective cell-type marker.
Franke et al., Mannheim, Germany. In Cell Tissue Res, 2008
Protein p0071 has been localized as a plaque protein in adhaerens junctions of diverse epithelia and certain vascular endothelia.
Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin.
Hatzfeld et al., Halle, Germany. In Cell Cycle, 2007
In this review p0071 catenin, a close relative of p120 catenin, associates and regulates RhoA-GTPase at the cleavage furrow during cytokinesis.
Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion?
Hatzfeld, Halle, Germany. In Biochim Biophys Acta, 2007
The plakophilins have been characterized as desmosomal proteins, whereas p120(ctn) and the closely related delta-catenin, ARVCF and p0071 associate with adherens junctions and play essential roles in stabilizing cadherin mediated adhesion.
The armadillo protein p0071 regulates Rho signalling during cytokinesis.
Hatzfeld et al., Halle, Germany. In Nat Cell Biol, 2006
These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis.
The p120 family of cell adhesion molecules.
Hatzfeld, Halle, Germany. In Eur J Cell Biol, 2005
p120 is the prototypic member of the p120 subfamily of armadillo-related proteins that includes p0071, delta-catenin/NPRAP, ARVCF and the more distantly related plakophilins 1-3.
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