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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Tumor necrosis factor receptor superfamily, member 4

OX40, CD134
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CAN, CD8, 4-1BB, CD25
Papers using OX40 antibodies
Human T lymphocyte proliferative response to resting porcine endothelial cells results from an HLA-restricted, IL-10-sensitive, indirect presentation pathway but also depends on endothelial-specific costimulatory factors
Briscoe David M. et al., In The Journal of Experimental Medicine, 1997
... Hollenbaugh, Bristol Myers Squibb), anti–human OX40 (Ancell Corp.), anti–human intercellular adhesion ...
Papers on OX40
Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice.
Redmond et al., Portland, United States. In Proc Natl Acad Sci U S A, Feb 2016
Here, we demonstrate that dual aOX40 (anti-CD134)/aCTLA-4 (anti-cytotoxic T-lymphocyte-associated protein 4) immunotherapy generated a potent antigen-specific CD8 T-cell response, enhancing expansion, effector function, and memory T-cell persistence.
Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.
Fujii et al., Niigata, Japan. In Virus Genes, Feb 2016
We found that Tax1 but not Tax2 induces the expression of OX40 ligand (OX40L) in a human T-cell line.
Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis.
Vella et al., Farmington, United States. In J Immunol, Feb 2016
CD134- and CD137-primed CD8 T cells mount powerful effector responses upon recall, but even without recall these dual-costimulated T cells respond to signal 3 cytokines such as IL-12.
OX40 signaling in head and neck squamous cell carcinoma: Overcoming immunosuppression in the tumor microenvironment.
Urba et al., Portland, United States. In Oral Oncol, Jan 2016
OX40 is a member of the tumor necrosis factor (TNF) receptor family and a potent co-stimulatory pathway that when triggered can enhance T-cell memory, proliferation and anti-tumor activity in patients with metastatic cancer.
Rationale for anti-OX40 cancer immunotherapy.
Marabelle et al., Villejuif, France. In Eur J Cancer, Jan 2016
Among them stands OX40 (CD134), a co-stimulatory molecule that can be expressed by activated immune cells.
[Immunotherapy in head and neck cancer].
Lang et al., Essen, Germany. In Hno, Nov 2015
Monoclonal antibodies directed specifically toward T cell-stimulating receptors such as CD28 and CD134, or immunosuppressive receptors CTLA-4 and PD-1, are currently under investigation and have shown promising results.
Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS.
Melero et al., Pamplona, Spain. In Semin Oncol, Aug 2015
Co-stimulatory receptors include surface moieties that are constitutively expressed on resting lymphocytes such as CD28 or CD27 and others whose expression is induced upon recent previous antigen priming, ie, CD137, GITR, OX40, and ICOS.
OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.
Blanco et al., Bordeaux, France. In Immunity, Jul 2015
Here we showed the OX40 ligand (OX40L)-OX40 axis contributes to the aberrant Tfh response in SLE.
Characteristics of immunosuppressive regulatory T cells in cutaneous squamous cell carcinomas and role in metastasis.
Healy et al., Southampton, United Kingdom. In Lancet, Mar 2015
SCC Tregs expressed significantly higher levels of the co-stimulatory molecules OX40 (37·2% of FOXP3+ cell population, n=10 tumours) and 4-1BB (12·6%, n=9) than peritumoral non-regulatory T cells and Tregs from peripheral blood and normal skin (p=0·0005).
Immunostimulation by OX40 Ligand Transgenic Ewing Sarcoma Cells.
Föll et al., Halle, Germany. In Front Oncol, 2014
OX40 (CD134) and OX40 ligand (OX40L = CD252; also known as tumor necrosis factor ligand family member 4) is one example of such receptor/ligand pair with co-stimulatory function.
Stability of Regulatory T Cells Undermined or Endorsed by Different Type-1 Cytokines.
Barnaba et al., Roma, Italy. In Adv Exp Med Biol, 2014
Furthermore, cytokine signals can be finely tuned by the concomitant stimulation of costimulatory or coinhibitory receptors, such as OX40 and PD-1 respectively, within inflamed tissues.A model may be envisaged of an alternate Treg response to type-1 cytokines, being hampered or boosted by early or late phase cytokines, respectively.
Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran.
Hojjat-Farsangi et al., Sārī, Iran. In Glob J Health Sci, 2014
OX40 is a member of the TNF super family receptor protein.
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Farrar et al., Minneapolis, United States. In Nat Immunol, 2014
We found here that Treg cell progenitors had high expression of the TNFRSF members GITR, OX40 and TNFR2.
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Knolle et al., Bonn, Germany. In Nat Immunol, 2013
Signaling via tumor-necrosis factor (TNF) caused iMATE formation that facilitated costimulation dependent on the receptor OX40 for expansion of the CTL population.
OX40 signaling favors the induction of T(H)9 cells and airway inflammation.
Li et al., Boston, United States. In Nat Immunol, 2012
Here we found that the costimulatory receptor OX40 was a powerful inducer of T(H)9 cells in vitro and T(H)9 cell-dependent airway inflammation in vivo.
High levels of costimulatory receptors OX40 and 4-1BB characterize CD4+CD28null T cells in patients with acute coronary syndrome.
Kaski et al., London, United Kingdom. In Circ Res, 2012
We show that the inflammatory and cytotoxic function of CD4(+)CD28(null) T cells can be inhibited by blocking OX40 and 4-1BB costimulatory receptors.
OX40 ligand and programmed cell death 1 ligand 2 expression on inflammatory dendritic cells regulates CD4 T cell cytokine production in the lung during viral disease.
Schwarze et al., London, United Kingdom. In J Immunol, 2012
OX40L and PD-L2 expressed on dendritic cells differentially regulate cytokine production during recall responses in the lung.
Intratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells.
Piconese et al., Milano, Italy. In Eur J Immunol, 2011
following OX40 stimulation, blockade of Treg-cell suppression and enhancement of the Tem-cell adjuvant effect both concurred to free DCs from immunosuppression and activate the immune response against the tumor.
Assessment of activity of an adhesion molecule CD134 and CD137 in colorectal cancer patients.
Kędra et al., Białystok, Poland. In Pol Przegl Chir, 2011
CD137 activity is directly proportional to colorectal cancer stage. Surgical resection of the tumor results in increased CD134 and CD137 expression
Tissue specific deletion of inhibitor of kappa B kinase 2 with OX40-Cre reveals the unanticipated expression from the OX40 locus in skin epidermis.
Seddon et al., London, United Kingdom. In Plos One, 2011
Development of skin lesions was rather more likely explained by deletion of Ikbk2 in skin keratinocytes in OX40(Cre) mice.
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