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Ovarian tumor suppressor candidate 2

OVCA2

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Top mentioned proteins: OVCA1, p53, p13, Iris, ACID

Papers on OVCA2

Differentially regulated genes in MEN1-transfected BON cells using RT-differential display and oligonucleotide microarrays.

Skogseid et al., Uppsala, Sweden. In Anticancer Res, 2009

RESULTS: Three genes (SMARCC1, OVCA2 and SRp55) found to be differentially regulated on differential display were corroborated by northern blots on cell line RNA when comparing MEN1 transfected cells with control (empty vector transfection).

Minimal deletion regions in lung squamous cell carcinoma: association with abnormality of the DNA double-strand break repair genes and their applications on gene identification and prognostic biomarkers.

Wang et al., Tainan City, Taiwan. In Lung Cancer, 2008

The candidate genes GAS7 and OVCA2 in the MDR17pA (17p13.1-p13.2) were further examined for mRNA expression.

Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY.

Lubec et al., Vienna, Austria. In Cancer Lett, 2006

OVCA2 is a putative serine-hydrolase.

Establishment and characterization of xenografts and cancer cell cultures derived from BRCA1 -/- epithelial ovarian cancers.

Montagna et al., Padova, Italy. In Eur J Cancer, 2006

We derived two ovarian cancer cell lines, termed PD-OVCA1 and PD-OVCA2, both from patients previously treated with chemotherapy, that propagate in SCID mice as well as in vitro for a limited number of passages.

Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae.

Kierzek et al., Warsaw, Poland. In J Biol Chem, 2005

FSH3p shares significant sequence similarity with the product of the human tumor suppressor gene OVCA2.

Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast.

Fetrow et al., San Diego, United States. In Mol Cell Proteomics, 2004

OVCA2, a potential human tumor suppressor, and DYR-SCHPO, a dihydrofolate reductase from Schizosaccharomyces pombe, are members of this family.

OVCA2 is downregulated and degraded during retinoid-induced apoptosis.

GeneRIF

Godwin et al., Philadelphia, United States. In Int J Cancer, 2002

is downregulated and degraded during retinoid-induced apoptosis

High frequency allelic loss on chromosome 17p13.3-p11.1 in esophageal squamous cell carcinomas from a high incidence area in northern China.

Taylor et al., Beijing, China. In Carcinogenesis, 2000

A number of genes have already been identified in these deleted regions, including: OVCA1, OVCA2 and HIC-1 in deletion region I; p53 in deletion region II; ZNF18, ZNF29, ALDH3 and ALDH10 in deletion region III.

Analysis of allelic imbalance on chromosome 17p13 in stage I and stage II epithelial ovarian cancers.

Casey et al., Cleveland, United States. In Gynecol Oncol, 1998

A region of AI, defined by marker D17S654, close to candidate genes OVCA1 and OVCA2, was identified distal to p53 and occurred in 11 of 23 (48%) informative tumors.

Identification of two candidate tumor suppressor genes on chromosome 17p13.3.

Godwin et al., Philadelphia, United States. In Cancer Res, 1996

Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCA1 and OVCA2, that map to 17p13.3.