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Orthodenticle homolog 2

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: CAN, Pax6, Sox2, Otx1, HAD
Papers on Otx2
Donating Otx2 to support neighbor neuron survival.
Kim et al., Taejŏn, South Korea. In Bmb Rep, Feb 2016
UNASSIGNED: Mutations of orthodentricle homeobox 2 (OTX2) in human and mice often cause retinal dystrophy and nyctalopia, suggesting a role of OTX2 in mature retina in addition to its functions in eye and retinal development.
Glyphosate induces neurotoxicity in zebrafish.
Ochs et al., Fairfield, United States. In Environ Toxicol Pharmacol, Feb 2016
Concomitant with structural changes in the developing brain, using in situ hybridization analysis, we detect decreases in genes expressed in the eye, fore and midbrain regions of the brain including pax2, pax6, otx2 and ephA4.
Harvesting clues from genome wide transcriptome analysis for exploring thalidomide mediated anomalies in eye development of chick embryo: Nitric oxide rectifies the thalidomide mediated anomalies by swinging back the system to normal transcriptome pattern.
Chatterjee et al., Chennai, India. In Biochimie, Jan 2016
8% of the significantly modulated genes have been implicated in eye development including Pax6, OTX2, Dkk1 and Shh.
Recent advances in central congenital hypothyroidism.
Dattani et al., London, United Kingdom. In J Endocrinol, Dec 2015
Genetic ascertainment is possible in a minority of cases and reveals mutations in genes controlling the TSH biosynthetic pathway (TSHB, TRHR, IGSF1) in isolated TSH deficiency, or early (HESX1, LHX3, LHX4, SOX3, OTX2) or late (PROP1, POU1F1) pituitary transcription factors in combined hormone deficits.
Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma.
MacLeod et al., Braunschweig, Germany. In Oncotarget, Dec 2015
In Hodgkin lymphoma (HL) we recently identified deregulated expression of homeobox genes MSX1 and OTX2 which are physiologically involved in development of the embryonal neural plate border region.
Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons.
Kim et al., Taejŏn, South Korea. In Cell Rep, Dec 2015
OTX2 (orthodenticle homeobox 2) haplodeficiency causes diverse defects in mammalian visual systems ranging from retinal dysfunction to anophthalmia.
OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development.
Terrinoni et al., Roma, Italy. In Aging (albany Ny), Nov 2015
OTX1 and OTX2 are important for the cochlea and macula development, indeed when OTX1 is knocked down, these organs undergo developmental failure.
Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9.
Zhang et al., Madison, United States. In Cell Stem Cell, Sep 2015
This two-step strategy was used to establish human embryonic stem cell (hESC) and induced pluripotent stem cell (iPSC) lines with iKO of SOX2, PAX6, OTX2, and AGO2, genes that exhibit diverse structural layout and temporal expression patterns.
Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma.
MacLeod et al., Braunschweig, Germany. In Plos One, 2014
Our data demonstrate that OTX1 and OTX2 are aberrantly expressed in both HL patients and cell lines.
The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease.
Fawcett, Cambridge, United Kingdom. In Prog Brain Res, 2014
In addition OTX2 binds to CS-E motifs, where it can act on parvalbumin interneurons to maintain the PNNs.
Markers of Pluripotency in Human Amniotic Epithelial Cells and Their Differentiation to Progenitor of Cortical Neurons.
Díaz et al., Ciudad López Mateos, Mexico. In Plos One, 2014
Finally, when hAEC were treated with growth factors and small molecules, they expressed markers characteristic of cortical progenitors (TBR2, OTX2, NeuN and β-III-tubulin).
The genetic architecture of microphthalmia, anophthalmia and coloboma.
FitzPatrick et al., Edinburgh, United Kingdom. In Eur J Med Genet, 2014
In severe bilateral cases (anophthalmia or severe microphthalmia) the genetic cause is now identifiable in approximately 80 percent of cases, with de novo heterozygous loss-of-function mutations in SOX2 or OTX2 being the most common.
New insights into septo-optic dysplasia.
Gucev et al., Niš, Serbia. In Prilozi, 2013
SOX2, SOX3 and OTX2 mutations have also been identified in some forms of SOD.
The homeobox gene Otx2 in development and disease.
Lamonerie et al., Brussels, Belgium. In Exp Eye Res, 2013
The Otx2 gene encodes a transcription factor essential for the normal development of brain, cerebellum, pineal gland, and eye.
A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation, and an underdeveloped left optic nerve.
Hokken-Koelega et al., Rotterdam, Netherlands. In Eur J Endocrinol, 2012
A novel missense heterozygous OTX2 mutation acts as a dominant negative inhibitor of target gene expression in a patient with combined pituitary hormone deficiency (CPHD), pituitary malformation, and optic nerve hypoplasia.
Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex.
Prochiantz et al., Paris, France. In J Neurosci, 2012
We find that perineuronal nets (PNNs) on the surfaces of parvalbumin expressing cells permit the specific, constitutive capture of Otx2 in visual cortex.
Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors.
Aizawa et al., Kōbe, Japan. In Mol Cell Biol, 2012
class III POU factors and Gbx2 share the same target site, TAATTA, in the FM enhancer and their region-specific binding restricts Otx2 expression at the midbrain-hindbrain boundary
Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells.
Yan et al., Durham, United States. In Plos One, 2011
a role for Otx2 in altering the dynamics of neuronal progenitor cell proliferation
Brain development is a multi-level regulated process--the case of the OTX2 gene.
Gat-Yablonski, Petah Tikva, Israel. In Pediatr Endocrinol Rev, 2011
There is no genotype-phenotype correlation and the severity of the disease varies not only by the specific OTX2 mutations but also among individuals harboring the same mutation, suggesting the involvement of multiple levels of regulation.
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
Forrest et al., Bethesda, United States. In Nat Rev Neurosci, 2010
Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate.
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