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RNA binding motif protein 15

Ott, RBM15, OTT1
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, p13, V1a, Mal, OUT
Papers on Ott
RBM15 functions in Blood diseases.
Luo et al., Baltimore, United States. In Curr Cancer Drug Targets, Feb 2016
UNASSIGNED: RBM15, an RNA-binding protein, plays important roles in the growth and apoptosis of cells, especially blood cells through regulating multiple signal pathways such as Notch and Wnt.
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
Zhao et al., Birmingham, United States. In Elife, Dec 2015
UNASSIGNED: RBM15, an RNA binding protein, determines cell-fate specification of many tissues including blood.
Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study.
Raimondi et al., Memphis, United States. In Blood, Oct 2015
On the basis of frequency and prognosis, AMKL can be classified to 3 risk groups: good risk-7p abnormalities; poor risk-normal karyotypes, -7, 9p abnormalities including t(9;11)(p22;q23)/MLL-MLLT3, -13/13q-, and -15; and intermediate risk-others including t(1;22)(p13;q13)/OTT-MAL (RBM15-MKL1) and 11q23/MLL except t(9;11).
A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.
Brockdorff et al., Yokohama, Japan. In Cell Rep, Aug 2015
Validation experiments performed on several of the top hits identified the SPOC domain RNA binding proteins Rbm15 and Spen and Wtap, a component of the m6A RNA methyltransferase complex, as playing an important role in the establishment of Xist-mediated silencing.
Neonatal acute megakaryoblastic leukemia mimicking congenital neuroblastoma.
Kanegane et al., Toyama, Japan. In Clin Case Rep, Mar 2015
Autopsy revealed that the tumor cells in the liver indicated acute megakaryocytic leukemia with the RBM15-MKL1 fusion gene.
Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
Raffel et al., Worcester, United States. In Blood, Mar 2015
Ott1 (Rbm15), a spliceosomal component originally identified as a fusion partner in t(1;22)-associated acute megakaryocytic leukemia, is also essential for maintaining HSC quiescence under stress.
Multiple regions of Kaposi's sarcoma-associated herpesvirus ORF59 RNA are required for its expression mediated by viral ORF57 and cellular RBM15.
Zheng et al., Frederick, United States. In Viruses, Feb 2015
ORF57 specifically binds to a stem-loop region from nt 96596-96572 of the MRE, which also binds cellular RBM15.
Altered gene expression signature of early stages of the germ line supports the pre-meiotic origin of human spermatogenic failure.
Larriba et al., Barcelona, Spain. In Andrology, 2014
In SpF testicular samples, we observed down-regulation of genes involved in cell cycle (CCNE1 and POLD1), transcription and post-transcription regulation (DAZL, RBM15 and DICER1), protein degradation (FBXO32 and TM9SF2) and homologous recombination in meiosis (MRE11A and RAD50) which suggests that the expression of these genes is critical for a proper germ cell development.
Enterococci as Indicators of Environmental Fecal Contamination
Sassoubre et al., Boston, United States. In Unknown Journal, 2014
The use of enterococci as indicators of human fecal pollution or contamination can be problematic, however, because enterococci are also found in animal feces (Harwood, Whitlock, & Withington, 2000; Layton, Walters, Lam, & Boehm, 2010), in soils (Byappanahalli & Fujioka, 2004; Goto & Yan, 2011), and on plants (Byappanahalli, Shively, Nevers, Sadowsky, & Whitman, 2003; Imamura, Thompson, Boehm, & Jay, 2011; Müller, Ulrich, Ott, & Müller, 2001).
Detection of RBM15-MKL1 fusion was useful for diagnosis and monitoring of minimal residual disease in infant acute megakaryoblastic leukemia.
Morishima et al., Okayama, Japan. In Acta Med Okayama, 2013
We present here the case of a 4-month-old female AMKL patient who was diagnosed by presence of the RBM15-MKL1 (OTT-MAL) fusion transcript by RT-PCR.
Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.
Hamakubo et al., In J Biol Chem, 2013
Here we show that WTAP forms a novel protein complex including Hakai, Virilizer homolog, KIAA0853, RBM15, the arginine/serine-rich domain-containing proteins BCLAF1 and THRAP3, and certain general splicing regulators, most of which have reported roles in post-transcriptional regulation.
Mosaic small supernumerary marker chromosome 1 at amniocentesis: prenatal diagnosis, molecular genetic analysis and literature review.
Wang et al., Taipei, Taiwan. In Gene, 2013
We discuss the genotype-phenotype correlation of the involved genes of ALX3, RBM15, NTNG1, SLC25A24, GPSM2, TBX15 and NOTCH2 in this case.
Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress.
Raffel et al., Worcester, United States. In Blood, 2012
A requirement for Ott1 in stress hematopoiesis suggests that Ott1-dependent processes may converge with those affected by aging.
Acute megakaryoblastic leukemia with a four-way variant translocation originating the RBM15-MKL1 fusion gene.
Teixeira et al., Porto, Portugal. In Pediatr Blood Cancer, 2011
A four-way variant translocation originating the RBM15-MKL1 fusion gene is associated with acute megakaryoblastic leukemia.
Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.
Zheng et al., Bethesda, United States. In J Virol, 2011
HHV-8 ORF57 interacts with RBM15 and OTT3 to promote expression of viral intronless genes.
[Classification of myeloid leukemias].
Kuriyama, In Nihon Rinsho, 2009
AML with t(9; 11) (p22;q23); MLLT3-MLL, AML with t(6;9) (p23; q34); DEK-NUP214, AML with inv(3) (q21q26.2) or t(3; 3) (q21 ; q26.2); RPN1-EVI1 and AML (megakaryoblastic) with t(1; 22) (p13; q13); RBM15-MKL1 are added to the subtype of AML with recurrent genetic abnormalities, and AML with gene mutations of NPM1 and CEBPA are also added as provisional entities of it.
c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development.
Morris et al., Memphis, United States. In Blood, 2009
c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development.
Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen.
Gilliland et al., Boston, United States. In Mol Cell Biol, 2009
Ott1 (Rbm15) has essential roles in hematopoietic, trophoblast, cardiac, and splenic development
[Genomic and molecular medicine].
Baranov, Saint Petersburg, Russia. In Mol Biol (mosk), 2004
The review considers the contribution of the Laboratory of Prenatal Diagnostics of the Ott Institute of Obstetrics and Gynecology to the development of molecular medicine in Russia.
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.
Hitzler et al., Memphis, United States. In Nat Genet, 2001
Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.
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