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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Orthopedia homolog

This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: ACID, Oxytocin, CAN, HAD, V1a
Papers on Otp
High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis.
Bar-Sagi et al., New York City, United States. In Assay Drug Dev Technol, Sep 2015
Hits from the primary screen were confirmed with siRNA reagents from a different library (GE, OTP), which allowed us to mitigate potential off-target effects.
Patterns of hypothalamic regionalization in amphibians and reptiles: common traits revealed by a genoarchitectonic approach.
Moreno et al., Madrid, Spain. In Front Neuroanat, 2014
Shared features in the two species are: (1) The supraoptoparaventricular region (SPV) is defined by the expression of Otp and the lack of Nkx2.1/Isl1.
Regionalized differentiation of CRH, TRH, and GHRH peptidergic neurons in the mouse hypothalamus.
Díaz et al., Albacete, Spain. In Brain Struct Funct, 2014
In this context, we examined the ontogeny of peptidergic cell populations expressing Crh, Trh, and Ghrh mRNAs in the mouse hypothalamus, comparing their distribution relative to the major progenitor domains characterized by molecular markers such as Otp, Sim1, Dlx5, Arx, Gsh1, and Nkx2.1.
Characterization of the hypothalamus of Xenopus laevis during development. II. The basal regions.
Moreno et al., Madrid, Spain. In J Comp Neurol, 2014
The tuberal hypothalamus is defined by the expression of Nkx2.1, xShh, and Isl1, and rostral and caudal portions can be distinguished by the distinct expression of Otp rostrally and Nkx2.2 caudally.
A vertebrate-conserved cis-regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response.
Ryu et al., Heidelberg, Germany. In Bmc Dev Biol, 2013
BACKGROUND: The homeodomain transcription factor orthopedia (Otp) is an evolutionarily conserved regulator of neuronal fates.
An exploration of pathways involved in lung carcinoid progression using gene expression profiling.
Speel et al., Maastricht, Netherlands. In Carcinogenesis, 2013
At the individual gene level, BIRC5 (survivin), BUB1, CD44, IL20RA, KLK12 and OTP were independent predictors of patient outcome.
Optogenetic patterning of whisker-barrel cortical system in transgenic rat expressing channelrhodopsin-2.
Yawo et al., Sendai, Japan. In Plos One, 2013
Our methods of generating an optogenetic tactile pattern (OTP) can be expected to facilitate studies on how the spatiotemporal pattern of touch is represented in the somatosensory cortex, as Hubel and Wiesel did in the visual cortex.
The olfactory amygdala in amniotes: an evo-devo approach.
Medina et al., Lleida, Spain. In Anat Rec (hoboken), 2013
Lhx6, Shh, Tbr1, Lhx9, Lhx5, Otp, and Pax6) in embryos of mouse, chicken, emydid turtles, and a pipid frog.
CD44 and OTP are strong prognostic markers for pulmonary carcinoids.
Speel et al., Maastricht, Netherlands. In Clin Cancer Res, 2013
Because histologic classification in typical and atypical carcinoids is difficult and its reliability to predict disease outcome varies, we evaluated three genes as potential prognostic markers, that is, orthopedia homeobox (OTP), CD44, and rearranged during transfection (RET).
Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2.
Ryu et al., Heidelberg, Germany. In Development, 2013
We show that Vip- and Uts1-positive neurons develop in distinct domains in the mammillary area defined by the differential expression of the transcription factors Fezf2, Otp, Sim1a and Foxb1.2.
Evolution of homeobox genes.
Holland, Oxford, United Kingdom. In Wiley Interdiscip Rev Dev Biol, 2013
The PRD class is also diverse and includes Pax2/5/8, Pax3/7, Pax4/6, Gsc, Hesx, Otx, Otp, and Pitx genes.
Role of homeobox genes in the hypothalamic development and energy balance.
Nonogaki et al., Sendai, Japan. In Front Biosci, 2012
During mammalian embryonic development, homeobox genes, including orthopedia (Otp), a brain-specific homeobox transcription factor (Bsx) and a thyroid transcription factor-1 (TTF-1), are expressed in the hypothalamus.
Orthopedia transcription factor otpa and otpb paralogous genes function during dopaminergic and neuroendocrine cell specification in larval zebrafish.
Driever et al., Freiburg, Germany. In Plos One, 2012
In zebrafish, two paralogous otp genes, otpa and otpb, are present in the genome.
Genome-wide identification of OTP gene as a novel methylation marker of breast cancer.
Lee et al., Taejŏn, South Korea. In Oncol Rep, 2012
we successfully identified a novel gene OTP frequently methylated in breast cancer by genome-wide screening. Our results suggest that the OTP gene may play a crucial role in breast carcinogenesis.
Contribution of genoarchitecture to understanding forebrain evolution and development, with particular emphasis on the amygdala.
Abellán et al., Lleida, Spain. In Brain Behav Evol, 2010
In all tetrapods studied, the amygdala includes at least 4 components: (1) a ventral pallial part, characterized by expression of Lhx2 and Lhx9, that includes part of the basal amygdalar complex in mammals and a caudal part of the dorsal ventricular ridge in sauropsids and also produces a cell subpopulation of the medial amygdala; (2) a striatal part, characterized by expression of Pax6 and/or Islet1, which includes the central amygdala in different species; (3) a pallidal part, characterized by expression of Nkx2.1 and, in amniotes, Lhx6, which includes part of the medial amygdala, and (4) a hypothalamic part (derived from the supraoptoparaventricular domain or SPV), characterized by Otp and/or Lhx5 expression, which produces an important subpopulation of cells of the medial extended amygdala (medial amygdala and/or medial bed nucleus of the stria terminalis).
A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei.
De Carlos et al., Madrid, Spain. In Nat Neurosci, 2010
diencephalic neurons colonize the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior
Ontogeny of vasotocin-expressing cells in zebrafish: selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area.
Glasgow et al., Akron, United States. In Dev Dyn, 2008
Results describe the ontogeny of vasotocin-expressing cells in zebrafish, and the selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area.
Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development.
Driever et al., Freiburg, Germany. In Curr Biol, 2007
Orthopedia is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system.
Differential regulation of the zebrafish orthopedia 1 gene during fate determination of diencephalic neurons.
Cotelli et al., Milano, Italy. In Bmc Dev Biol, 2005
Otp1 transcription factor is important for regulation of diencephalon development and early neuronal progenitors.
Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm.
Roberts et al., Colombia. In Nature, 1987
The active substance implicated in signalling maternal recognition of pregnancy in the sheep is an embryonic secretory protein, known as ovine trophoblast protein-1 (oTP-1) (refs 2-4), which is targeted in a paracrine manner to the uterine epithelium of the mother.
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