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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Oxidative-stress responsive 1

OSR1, Odd-skipped related 1
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SPAK, PAK1, WNK4, CAN, V1a
Papers on OSR1
Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.
Yang et al., Shanghai, China. In Biochem Biophys Res Commun, Feb 2016
The disease is characterized by overactivity of the renal sodium chloride cotransporter (NCC), which is phosphorylated and activated by the WNK-stimulated Ste20-type kinases, SPAK and OSR1.
ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screen.
Lavin et al., Australia. In Mol Cell Proteomics, Jan 2016
We validated the phosphorylation of three of these proteins (OSR1, HDGF and ccdc82) as ATM-dependent after H2O2 exposure and another protein (S100A11) demonstrated ATM-dependence for translocation from the cytoplasm to the nucleus.
SPAK and OSR1 Sensitive Kir2.1 K+ Channels.
Lang et al., Tübingen, Germany. In Neurosignals, Jan 2016
The present study explored whether Kir2.1 channels are sensitive to the transporter and channels regulating kinases SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), which are in turn regulated by WNK (with-no-K[Lys]) kinases.
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.
Naguro et al., Tokyo, Japan. In Sci Rep, Dec 2015
The With No lysine [K] (WNK)-Ste20-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway has been reported to be a crucial signaling pathway for triggering pseudohypoaldosteronism type II (PHAII), an autosomal dominant hereditary disease that is characterized by hypertension.
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Chambers et al., Tokyo, Japan. In Nat Genet, Nov 2015
The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function.
Gordon Syndrome: a continuing story.
O'Shaughnessy, Cambridge, United Kingdom. In Pediatr Nephrol, Nov 2015
However, it took several years to appreciate that these kinases operated in a cascade with downstream serine/threonine kinases (SPAK and OSR1) actually phosphorylating and activating NCC and the closely related cotransporters NKCC1 and NKCC2.
[WNK-SPAK-SLC12A signal cascade is a new therapeutic target for hypertension].
Uchida et al., In Nihon Rinsho, Sep 2015
WNK-oxidative stress-responsive 1 (OSR1) /STE20/SPS1-related proline-alanine-rich protein kinase(SPAK)-SLC12A transporters cascade regulates blood pressure through NaCl reabsorption in kidney and vasoconstriction.
Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.
Uchida et al., Tokyo, Japan. In Nephrol Dial Transplant, Aug 2015
Rigorous studies have demonstrated that WNK kinases constitute a signaling cascade with oxidative stress-responsive gene 1 (OSR1), Ste20-related proline-alanine-rich kinase (SPAK) and the solute carrier family 12a (SLC12a) transporter, including thiazide-sensitive NaCl cotransporter.
Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
Gamba et al., Mexico. In Am J Physiol Cell Physiol, Jun 2015
Extensive research has shown that WNK1 and WNK4 are the targets for the KLHL3-CUL3 complex and that WNKs modulate the activity of NCC by means of intermediary Ste20-type kinases known as SPAK or OSR1.
SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
Lang et al., In Cell Physiol Biochem, 2014
Kinases involved in regulation of epithelial transport and cell volume include SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), which are under control of WNK (with-no-K[Lys]) kinases.
Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1.
Lang et al., Bingen am Rhein, Germany. In Kidney Blood Press Res, 2014
BACKGROUND/AIMS: SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), kinases controlled by WNK (with-no-K[Lys] kinase), are powerful regulators of cellular ion transport and blood pressure.
Development and regulation of chloride homeostasis in the central nervous system.
Fukuda et al., Hamamatsu, Japan. In Front Cell Neurosci, 2014
KCC2 and NKCC1 functions are also regulated by phosphorylation by enzymes such as PKC, Src-family tyrosine kinases, and WNK1-4 and their downstream effectors STE20/SPS1-related proline/alanine-rich kinase (SPAK)-oxidative stress responsive kinase-1 (OSR1).
Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.
Delpire et al., Nashville, United States. In Physiol Rev, 2012
SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 (Sterile20)-related protein kinase family.
OSR1-sensitive regulation of Na+/H+ exchanger activity in dendritic cells.
Lang et al., Tübingen, Germany. In Am J Physiol Cell Physiol, 2012
Partial OSR1 deficiency influences Na(+)/H(+) exchanger activity, ROS formation, and migration of dendritic cells.
The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.
Gómez-Skarmeta et al., Sevilla, Spain. In Development, 2012
The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.
A variant OSR1 allele which disturbs OSR1 mRNA expression in renal progenitor cells is associated with reduction of newborn kidney size and function.
Goodyer et al., Montréal, Canada. In Hum Mol Genet, 2011
OSR1 is expressed in human mesenchymal stem cells, the blastemal component of Wilms tumors and CD24+/CD133+ progenitor cells isolated from the mature kidney.
Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome.
Yang et al., Taipei, Taiwan. In Proc Natl Acad Sci U S A, 2011
In the kidneys, NKCC2 but not NCC is the main target of OSR1 and the reduced p-NKCC2 in KSP-OSR1(-/-) mice may lead to a Bartter-like syndrome.
A SPAK isoform switch modulates renal salt transport and blood pressure.
Ellison et al., Portland, United States. In Cell Metab, 2011
An emerging model suggests that bumetanide- and thiazide-sensitive NaCl transporters (NKCC2 and NCC) along these segments are phosphorylated and activated by WNK kinases, via SPAK and OSR1.
Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.
Uchida et al., Tokyo, Japan. In J Cell Sci, 2011
Results clearly establish that PHAII caused by the WNK4 D561A mutation is dependent on the activation of the WNK-OSR1/SPAK-NCC cascade.
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.
Uchida et al., Tokyo, Japan. In Cell Metab, 2007
Increased phosphorylation of the kinases OSR1 and SPAK was also observed in the knockin mice.
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