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Osteoclast associated, immunoglobulin-like receptor

Oscar, osteoclast-associated receptor
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, NFATC, ACID, OUT
Papers on Oscar
Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors.
Gao et al., Beijing, China. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: Human osteoclast-associated receptor (OSCAR) is an immunoglobulin (Ig)-like collagen receptor that is up-regulated on osteoclasts during osteoclastogenesis and is expressed in a range of myeloid cells.
Open Questions.
In Hastings Cent Rep, Jan 2016
That trend in funding and interest is reflected, to some degree, in the second article, in which Oscar Zarate and colleagues explore how the Personal Genome Project, an endeavor launched at Harvard University to collect and share personal genetic and health information in order to facilitate research, is perceived by the people who consent to be part of it.
Early stage cervical cancer: Brachytherapy followed by type a hysterectomy versus type B radical hysterectomy alone, a retrospective evaluation.
Lambaudie et al., Limoges, France. In Eur J Surg Oncol, Jan 2016
MATERIALS AND METHODS: It is a retrospective and collaborative study between the Paoli Calmettes Institute (Marseille) and the Oscar Lambret Center (Lille) from 2001 to 2013, in patients with tumors FIGO stages IA1, IA2, IB1 and IIA less than 2 cm of diameter, without pelvic lymph node involvement.
IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1).
Zhang et al., Wuhan, China. In J Biol Chem, Jan 2016
Furthermore, LPS-PG and IL-1 differentially regulate RANKL-costimulatory receptor OSCAR (osteoclast-associated receptor) expression and Ca(2+) oscillations induced by RANKL.
Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture.
Luthringer et al., Geesthacht, Germany. In Acta Biomater, Nov 2015
The results of intracellular alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP) activities as well as protein and gene expressions of receptor activator of nuclear factor kappa-B ligand (RANKL), macrophage colony-stimulating factor (M-CSF), and osteoclast-associated receptor (OSCAR) revealed significantly enhanced formation of osteoblasts whereas decreased osteoclastogenesis in the cultures with high concentrations of Mg extract (2× and 1× dilutions).
The Marin Lab at the Dawn of Cognitive Neuropsychology.
Schwartz, Moss, Norway. In Cogn Behav Neurol, Sep 2015
This essay discusses the intellectual developments in psychology, linguistics, and behavioral neurology that shaped Oscar Marin's approach to disorders of high cortical function.
Revisiting the Single-Case Approach to Studying Reading Disorders.
Laszlo et al., Binghamton, United States. In Cogn Behav Neurol, Sep 2015
Oscar Marin was a neurologist with a remarkably broad interest in the brain and its function.
Neuropsychological Thoughts, Then and Now: A Tribute to Oscar Marin.
Patterson, Cambridge, United Kingdom. In Cogn Behav Neurol, Sep 2015
This brief paper, inspired by an invitation to acknowledge and celebrate Oscar Marin's great contributions to cognitive neurology and neuropsychology, reviews the case of a patient, T.P., who had significant deficits of naming, reading, and spelling.
Oscar Marin and the Creation of a Cognitive Neuropsychology Laboratory.
Posner, Eugene, United States. In Cogn Behav Neurol, Sep 2015
Created and headed by Oscar Marin and the author, in affiliation with the University of Oregon, the lab brought together students, fellows, and visiting experts in neurology, psychology, psychiatry, neuropsychology, neurobiology, neurophysiology, and computation.
The controversy of sports technology: a systematic review.
Dyer, Poole, United Kingdom. In Springerplus, 2014
Whilst the sport of golf had the highest number of case studies, it was found that a significant level of attention had been recorded in the cases of Oscar Pistorius use of prosthetic legs in athletics and the use of full length swimsuits in swimming.
Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss.
Haynes et al., Adelaide, Australia. In J Immunol Res, 2014
Although animal models are briefly discussed, the focus of this review is on the expression of ITAM associated molecules in relation to inflammation induced localized bone loss in RA, chronic periodontitis, and periprosthetic osteolysis, with an emphasis on the soluble and membrane bound factor osteoclast-associated receptor (OSCAR).
Chorea: A Journey through History.
Cardoso et al., Juiz de Fora, Brazil. In Tremor Other Hyperkinet Mov (n Y), 2014
In 1841, Charles Oscar Waters gave a concise account of a syndrome, likely to be Huntington's disease (HD), later described further by George Huntington and named after him.
Serum amyloid A inhibits RANKL-induced osteoclast formation.
Bae et al., Suwŏn, South Korea. In Exp Mol Med, 2014
SAA not only markedly blocked the expression of several osteoclast-associated genes (TNF receptor-associated factor 6 and osteoclast-associated receptor) but also strongly induced the expression of negative regulators (MafB and interferon regulatory factor 8).
Synchronicity in the performing arts: Oscar Wilde's nightmare?
de Haas, Den Haag, Netherlands. In Clin Rheumatol, 2013
Neurological synchronicity is a basic function used in and between living organisms.
The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells.
Hofbauer et al., Dresden, Germany. In Endocrinology, 2011
OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
Trowsdale et al., Cambridge, United Kingdom. In J Clin Invest, 2011
Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice.
The role of osteoclast-associated receptor in osteoimmunology.
Goettsch et al., Marburg an der Lahn, Germany. In J Immunol, 2011
This review discusses the structure-function relationship, expression pattern, and physiological role of OSCAR in osteoimmunology and summarizes its potential implications for human diseases.
Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.
Kim et al., Kwangju, South Korea. In J Mol Biol, 2008
Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis.
Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis.
Schett et al., Erlangen, Germany. In Arthritis Rheum, 2008
OSCAR (osteoclast associated immunoglobulin-like receptor)is expressed by erosion front osteoclasts and by synovial microvessels mononuclear cells. OSCAR is induced in monocytes of rheumatod arthritis patients, facilitating osteoclast differentiation
Self-cleaning surfaces--virtual realities.
Blossey, Villeneuve-d'Ascq, France. In Nat Mater, 2003
In the 19th century, Oscar Wilde stated "We live, I regret to say, in an age of surfaces".
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