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Lanosterol synthase

OSC, lanosterol synthase, ERG7, Erg7p
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, HAD, STEP
Papers on OSC
Gap junctions are essential for murine primordial follicle assembly immediately before birth.
Zhang et al., Beijing, China. In Reproduction, Feb 2016
In addition, the expression of ovarian somatic cell (OSC)-specific genes, such as Notch2, Foxl2 and Irx3, was negatively affected by GJC blockers, whereas oocyte-related genes, such as Ybx2, Nobox and Sohlh1, were hardly affected, implying that the establishment of GJC during this period may be more important to OSCs than to oocytes.
Lanosterol Synthase Gene Polymorphisms and Changes in Endogenous Ouabain in the Response to Low Sodium Intake.
Manunta et al., Milano, Italy. In Hypertension, Feb 2016
Furthermore, lanosterol synthase, an enzyme involved in cholesterol biosynthesis, has a missense polymorphism (rs2254524 V642L) that affects EO biosynthesis in adrenocortical cells.
Increased lanosterol turnover: a metabolic burden for daunorubicin-resistant leukemia cells.
Nordström et al., Umeå, Sweden. In Med Oncol, Jan 2016
Treatment of CEM and CEM/R2 cells with cholesterol biosynthesis inhibitors acting on the enzymes squalene epoxidase and lanosterol synthase, both also involved in the 24,25-epoxycholesterol shunt pathway, revealed a connection of this pathway to lanosterol turnover.
Arylpiperidines as a new class of oxidosqualene cyclase inhibitors.
Bracher et al., München, Germany. In Eur J Med Chem, Jan 2016
UNASSIGNED: The cyclization of oxidosqualene to lanosterol, catalyzed by the enzyme oxidosqualene cyclase (OSC), goes through a number of carbocationic high energy intermediates (HEI), and mimicking these intermediates is a promising approach for the development of OSC inhibitors.
Mitigation of Tumor-Associated Fibroblast-Facilitated Head and Neck Cancer Progression With Anti-Hepatocyte Growth Factor Antibody Ficlatuzumab.
Thomas et al., Manhattan, United States. In Jama Otolaryngol Head Neck Surg, Jan 2016
Representative HNSCC cell lines HN5, UM-SCC-1, and OSC-19 were used in these studies.
Ordered Subspace Clustering With Block-Diagonal Priors.
Yin et al., In Ieee Trans Cybern, Dec 2015
In this paper, we study the subspace clustering problem for sequential data and propose a new clustering method, namely ordered sparse clustering with block-diagonal prior (BD-OSC).
Lanosterol reverses protein aggregation in cataracts.
Zhang et al., Chengdu, China. In Nature, Aug 2015
It is synthesized by lanosterol synthase (LSS) in a key cyclization reaction of a cholesterol synthesis pathway.
Role of H2S Donors in Cancer Biology.
Deng et al., Singapore, Singapore. In Handb Exp Pharmacol, 2014
Hydrogen sulfide (H2S) donors including organosulfur compounds (OSC), inorganic sulfide salts, and synthetic compounds are useful tools in studies to elucidate the effects of H2S in cancer biology.
Pseudo-immortalization of postnatal cochlear progenitor cells yields a scalable cell line capable of transcriptionally regulating mature hair cell genes.
Zuo et al., Memphis, United States. In Sci Rep, 2014
These cells, termed "Conditionally Reprogrammed Otic Stem Cells" (CR-OSC), are able to bypass the senescence inherent to cochlear progenitor cells without genetic alterations, allowing for the generation of over 15 million cells from a single cochlea.
Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial.
Caudle et al., Praha, Czech Republic. In Reprod Biol Endocrinol, 2011
In fetal and adult human ovaries the ovarian surface epithelium cells called ovarian stem cells (OSC) are bipotent stem cells for the formation of ovarian germ and granulosa cells.
Potential role of nonstatin cholesterol lowering agents.
Pallottini et al., Roma, Italy. In Iubmb Life, 2011
In particular, due to their unique position downstream from HMGR, the inhibition of squalene synthase, farnesyl diphosphate farnesyltransferase (FDFT1), squalene epoxidase (SQLE), and oxidosqualene cyclase:lanosterol synthase (OSC) should decrease plasma levels of cholesterol without affecting ubiquinone, dolichol, and isoprenoid metabolism.
Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
Zhu et al., Beijing, China. In J Biol Chem, 2009
Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions.
Shie et al., Chengyang, China. In Org Lett, 2008
A bicyclic intermediate with two altered deprotonation products, in conjunction with lanosterol, were isolated from the ERG7(Y707X) mutants
Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.
Bard et al., Indianapolis, United States. In Biochim Biophys Acta, 2008
This study provides new insights into the role of Erg27p in sterol biosynthesis.
Inhibition of squalene synthase upregulates PCSK9 expression in rat liver.
Lopez et al., Tampa, United States. In Arch Biochem Biophys, 2008
These observations suggest an involvement of PCSK9 in hepatic LDL receptor protein degradation and perhaps, in increasing the rate of LDL receptor cycling resulting in lower serum cholesterol levels in response to cholesterol biosynthesis inhibitors.
Functional polymorphisms of the Lss and Fdft1 genes in laboratory rats.
Higuchi et al., Matsumoto, Japan. In Exp Anim, 2007
The hypomorphic Lss(S) and Fdft1(S) alleles are not specific to the SCR strain, but are widely prevalent in several other laboratory rat strains.
Molecular genetics of plant sterol backbone synthesis.
Muranaka et al., Yokohama, Japan. In Lipids, 2007
Since three enzymes, 3-hydroxy-3-methylglutaryl CoA reductase, farnesyl diphosphate synthase, and lanosterol synthase, have been functionally characterized in planta, we reviewed recent progress on these enzymes.
Three subsets of sequence complexity and their relevance to biopolymeric information.
Trevors et al., Greenbelt, United States. In Theor Biol Med Model, 2004
Three qualitative kinds of sequence complexity exist: random (RSC), ordered (OSC), and functional (FSC).
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.
Ruf et al., Basel, Switzerland. In Nature, 2004
two crystal structures of the human membrane protein OSC: the target protein with an inhibitor that showed cholesterol lowering in vivo opens the way for the structure-based design of new OSC inhibitors
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes.
Shoemaker et al., Kirkland, United States. In Cell, 2004
Specifically, lanosterol synthase in the sterol biosynthetic pathway was identified as a target of the antianginal drug molsidomine, which may explain its cholesterol-lowering effects.
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