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Oxysterol binding protein-like 3

ORP3, OSBP-related protein 3, OSBPL3, Oxysterol binding protein related protein-3
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: OSBP, HAD, ACID, Insulin, ORP7
Papers on ORP3
Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy: A Report from the BELOB Trial.
French et al., Rotterdam, Netherlands. In Cancer Res, Feb 2016
In particular, expression of FMO4 and OSBPL3 was associated with treatment response.
A genomewide association mapping study using ultrasound-scanned information identifies potential genomic regions and candidate genes affecting carcass traits in Nellore cattle.
Ferraz et al., Pirassununga, Brazil. In J Anim Breed Genet, Dec 2015
Several of the significant markers detected were mapped onto functional candidate genes including ARFGAP3, CLSTN2 and DPYD for REA; OSBPL3 and SUDS3 for BFT; and RARRES1 and VEPH1 for RFT.
OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.
Olkkonen et al., Helsinki, Finland. In Exp Cell Res, Mar 2015
ORP3 is an R-Ras interacting oxysterol-binding protein homolog that regulates cell adhesion and is overexpressed in several cancers.
A vertebrate model for the study of lipid binding/transfer protein function: conservation of OSBP-related proteins between zebrafish and human.
Olkkonen et al., Helsinki, Finland. In Biochem Biophys Res Commun, 2014
Moreover, the domain structures of the distinct ORP proteins are almost identical between zebrafish and man, and molecular modeling in the present study suggests that ORD liganding by phosphatidylinositol-4-phosphate (PI4P) is a feature conserved between yeast Osh3p, human ORP3, and zebrafish Osbpl3.
Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism.
Li et al., Helsinki, Finland. In Prog Lipid Res, 2013
The functions assigned for mammalian ORPs include coordination of sterol and sphingolipid metabolism and mitogenic signaling (OSBP), control of ER-late endosome (LE) contacts and LE motility (ORP1L), neutral lipid metabolism (ORP2), cell adhesion (ORP3), cholesterol eggress from LE (ORP5), macrophage lipid homeostasis, migration and high-density lipoprotein metabolism (ORP8), apolipoprotein B-100 secretion (ORP10), and adipogenesis (ORP11).
Oxysterol-binding proteins: functions in cell regulation beyond lipid metabolism.
Olkkonen et al., Helsinki, Finland. In Biochem Pharmacol, 2013
Further functions assigned for ORPs include regulation of extracellular signal regulated kinase (ERK) activity (OSBP), control of ER-late endosome MCS and late endosome motility (ORP1L), regulation of β1-integrin activity (ORP3), modulation of hepatocyte insulin signaling and macrophage migration (ORP8), as well as post-Golgi vesicle transport, phosphatidylinositol-4-phosphate and target of rapamycin complex 1 signaling and nitrogen sensing (Saccharomyces cerevisiae Osh4p).
A gain-of-function mutation in IAA8 alters Arabidopsis floral organ development by change of jasmonic acid level.
Lu et al., Wuhan, China. In Plant Mol Biol, 2013
These results indicated that in IAA8::GFP-mIAA8 plants, JA biosynthetic genes including DAD1 (AT2G44810), AOS (AT5G42650) and ORP3 (AT2G06050) were dramatically down-regulated and JA level in the flowers was reduced to 70 % of that in wild-type.
Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins.
Olkkonen et al., Helsinki, Finland. In Biochimie, 2013
In this study we generated RAW264.7 cells with ORP1L, ORP3, or ORP8 silenced using shRNA lentiviruses.
OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype.
Olkkonen et al., Helsinki, Finland. In Plos One, 2011
During SGBS cell adipogenic differentiation, ORP2, ORP3, ORP4, ORP7, and ORP8 mRNAs were down-regulated, while ORP11 was induced.
Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells.
Pastor-Anglada et al., Barcelona, Spain. In Haematologica, 2008
RESULTS: Sixteen of the twenty genes (DDB2, GADD45A, TYMS, BAX, TIGAR, FAS, TNFSF7, TNFSF9, CCNG1, CDKN1A, MDM2, SESN1, MAP4K4, PPM1D, OSBPL3 and WIG1) correlated with the ex vivo sensitivity of chronic lymphocytic leukemia cells to fludarabine, TIGAR (TP53-induced glycolysis and apoptosis regulator) being the gene that showed the strongest correlation (p<0.0001;
Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism.
Lisanti et al., Philadelphia, United States. In Cell Cycle, 2008
Oxysterol binding protein related protein-3, which has been implicated in intracellular lipid synthesis and transport, was increased 3.6-fold.
The R-Ras interaction partner ORP3 regulates cell adhesion.
Olkkonen et al., Helsinki, Finland. In J Cell Sci, 2008
The present findings demonstrate a new function of ORP3 as part of the machinery that controls the actin cytoskeleton, cell polarity and cell adhesion.
The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.
Olkkonen et al., Dresden, Germany. In Biochem J, 2007
Furthermore, in experiments with either truncated cDNAs encoding the OSBP-related ligand-binding domains of the ORPs or the full-length proteins, photo-25OH was bound to OSBP, ORP3, ORP4, ORP5, ORP6, ORP7, ORP8, ORP10 and ORP11.
Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.
Olkkonen et al., Helsinki, Finland. In Arterioscler Thromb Vasc Biol, 2007
OSBP regulates hepatic TG metabolism and suggest the involvement of OSBP in the insulin signaling pathways that control hepatic lipogenesis.
Altered protein profile in chronic myeloid leukemia chronic phase identified by a comparative proteomic study.
Abdelhay et al., Rio de Janeiro, Brazil. In Biochim Biophys Acta, 2006
Among these proteins, we pointed out c-Myc binding protein 1, 53BP1, Mdm4, OSBP-related protein 3 and Mortalin as putative candidates to BCR-ABL targets in chronic phase.
Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants.
Olkkonen et al., Helsinki, Finland. In Exp Cell Res, 2005
The intracellular targeting determinants of oxysterol binding protein (OSBP)-related protein 3 (ORP3) were studied using a series of truncated and point mutated constructs.
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