Mobile Phone Radiation: Physiological & Pathophysiologcal Considerations.
In Indian J Physiol Pharmacol, Apr 2015
Pathophysiological mechanisms of interaction of EMR at plasma membrane are calcium efflux from cell membranes, increased expression of stress proteins, influence on channels/gap junctions in cell membrane, overproduction of reactive oxygen species, ornithine decarboxylase activation, reduction in melatonin levels, decrease in protein kinase C activity, damage to DNA and change in gene expression in brain cells and altered blood-brain barrier.
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Roma, Italy. In Mini Rev Med Chem, 2014
The enzymes, belonging to the spermidine metabolism, i.e. arginase (ARG), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (AdoMetDC), spermidine synthase (SpdS), trypanothione synthetase (TryS or TSA), trypanothione reductase (TryR or TR), tryparedoxin peroxidase (TXNPx), deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are promising targets for the development of new drugs against leishmaniasis.
[The importance of putrescine in the human body].
Laizhou, China. In Postepy Hig Med Dosw (online), 2013
Especially important for the homeostasis of putrescine has ornithine decarboxylase and availability of its substrate--ornithine. Affecting to this enzyme is the simplest and widely used method of controlling the concentration of putrescine.
Vitamin B6-dependent enzymes in the human malaria parasite Plasmodium falciparum: a druggable target?
São Paulo, Brazil. In Biomed Res Int, 2013
The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism).
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma.
Hong Kong, Hong Kong. In Nat Med, 2013
Compared with wild-type AZIN1 protein, the edited form has a stronger affinity to antizyme, and the resultant higher AZIN1 protein stability promotes cell proliferation through the neutralization of antizyme-mediated degradation of ornithine decarboxylase (ODC) and cyclin D1 (CCND1).