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Solute carrier family 22

ORCTL3, hORCTL3, OCTL1, organic cation transporter-like 3, SLC22A13
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: ACID, p21, CAN, OCT, Pax1
Papers on ORCTL3
The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis.
Grimm et al., Ad Dammām, Saudi Arabia. In Oncogene, Apr 2015
ORCTL3 is a member of a group of genes, the so-called anticancer genes, that cause tumour-specific cell death.
SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct.
Gründemann et al., Köln, Germany. In Biochem J, 2014
In vertebrates, SLC22A13 is an evolutionarily conserved transport protein of the plasma membrane.
Isolation and characterization of the anticancer gene organic cation transporter like-3 (ORCTL3).
Grimm et al., London, United Kingdom. In Adv Exp Med Biol, 2013
ORCTL3, an organic cation/anion transporter expressed in various tissue types, was isolated in a genome-wide cDNA screen as a gene with a tumor-specific apoptosis activity.
Hijacking solute carriers for proton-coupled drug transport.
Thwaites et al., Newcastle upon Tyne, United Kingdom. In Physiology (bethesda), 2010
These transporters include PepT1 and PepT2 (SLC15A1/2), PCFT (SLC46A1), PAT1 (SLC36A1), OAT10 (SLC22A13), OATP2B1 (SLCO2B1), MCT1 (SLC16A1), and MATE1 and MATE2-K (SLC47A1/2).
Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers.
Grimm et al., London, United Kingdom. In Cell Death Differ, 2009
ORCTL3 protein causes cell death in v-src-transformed cells and in various human tumor cell lines but not in normal cells or untransformed cell lines.
Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13).
Burckhardt et al., Göttingen, Germany. In J Biol Chem, 2008
SLC22A13 is a new urate and high affinity nicotinate transporter
Identification of a kidney-specific mouse organic cation transporter like-1 (mOCTL1).
Cha et al., Seoul, South Korea. In Exp Mol Med, 2008
This clone was identified as an ortholog of ORCTL3 or OCTL-1.
Organic anion and cation transporters occur in pairs of similar and similarly expressed genes.
Nigam et al., San Diego, United States. In Biochem Biophys Res Commun, 2003
Additionally, we note that OATs and OCTs occur in the human and mouse genomes as tightly linked pairs (OAT1 and OAT3, UST3 and OAT5, OAT4 and URAT1/RST, OCT1 and 2, OCTN1 and 2, ORCTL3 and 4) that are also close phylogenetic relations, with Flipt1 and 2, and OAT2 the only unpaired family members.
Analysis of the gene structure of the human (SLC22A3) and murine (Slc22a3) extraneuronal monoamine transporter.
Brüss et al., Bonn, Germany. In J Neural Transm, 1999
The organization of the human OCT3 gene also shows pronounced similarities with other genes of human organic cation transporters such as those for hOCT1, hOCTN2, hORCTL3, and hORCTL4.
Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.
Nakamura et al., Tokyo, Japan. In Dna Res, 1999
The newly sequenced region contained a total of ten genes including six reported previously: phospholipase C delta 1 (PLCD1), human activin receptor type IIB (hActR-IIB), organic cation transporter-like 1 (OCTL1), organic cation transporter-like 2 (OCTL2), oxidative stress response 1 (OSR1), and human xylulokinase-like protein (XYLB).
Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters.
Nakamura et al., Tokyo, Japan. In Cytogenet Cell Genet, 1997
Through a large-scale sequencing of genomic DNA at 3p22-->p21.3, we have isolated two human genes (ORCTL3 alias OCTL1 and ORCTL4 alias OCTL2) encoding novel members of the family of organic-cation transporter molecules.
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