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Origin recognition complex, subunit 4

Orc4, Orc4p, OSBP2, OBPH1
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: Origin Recognition Complex, Cdc6, Orc6, ORC2, orc5
Papers using Orc4 antibodies
Corticosteroid therapy associated with ischemic necrosis of bone in systemic lupus erythematosus
Kubo Toshikazu et al., In Acta Orthopaedica, 1984
... Rabbits in the control group (n = 25) were fed with commercially available normal diet (ORC4; Oriental Yeast Co. Ltd., Tokyo, Japan), while ...
Papers on Orc4
ORC proteins in the mammalian zygote.
Ward et al., Honolulu, United States. In Cell Tissue Res, Jan 2016
The origin recognition complex (ORC) proteins, ORC1-6, are the first known proteins that bind DNA replication origins to mark the competency for the initiation of DNA synthesis.
De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome.
Yang et al., Houston, United States. In Am J Hum Genet, Jan 2016
Meier-Gorlin syndrome (MGS) is a genetically heterogeneous primordial dwarfism syndrome known to be caused by biallelic loss-of-function mutations in one of five genes encoding pre-replication complex proteins: ORC1, ORC4, ORC6, CDT1, and CDC6.
Drosophila model of Meier-Gorlin syndrome based on the mutation in a conserved C-Terminal domain of Orc6.
Chesnokov et al., Novosibirsk, Russia. In Am J Med Genet A, Nov 2015
Patients with MGS often carry mutations in the genes encoding the components of the pre-replicative complex such as Origin Recognition Complex (ORC) subunits Orc1, Orc4, Orc6, and helicase loaders Cdt1 and Cdc6.
Identification of genes regulating TRAIL-induced apoptosis in rheumatoid arthritis fibroblasts-like synoviocytes.
Morel et al., Montpellier, France. In Genes Immun, Oct 2015
These factors are implicated in different functions, such as the respiratory chain (ND3), the transport of lipids (OSBP2, PLTP), the regulation of signaling linked to extracellular factors (SULF2, GALNT1, SIAE) or the regulation of gene expression (TET2 and LARP6).
ORC4 surrounds extruded chromatin in female meiosis.
Ward et al., Honolulu, United States. In J Cell Biochem, May 2015
Six proteins, ORC1-6, make up the origin recognition complex (ORC) that initiates licensing of DNA replication origins.
Crystal structure of the eukaryotic origin recognition complex.
Berger et al., Baltimore, United States. In Nature, Apr 2015
Comparative analyses indicate that ORC encircles DNA, using its winged-helix domain face to engage the mini-chromosome maintenance 2-7 (MCM2-7) complex during replicative helicase loading; however, an observed out-of-plane rotation of more than 90° for the Orc1 AAA+ domain disrupts interactions with catalytic amino acids in Orc4, narrowing and sealing off entry into the central channel.
Modeling dynamic functional relationship networks and application to ex vivo human erythroid differentiation.
Guan et al., United States. In Bioinformatics, 2015
Furthermore, by comparing the static and the dynamic networks, we identified novel genes (such as OSBP2 and PDZK1IP1) that are potential drivers of erythroid cell differentiation.
Meier-Gorlin syndrome.
Bongers et al., Nijmegen, Netherlands. In Orphanet J Rare Dis, 2014
Mutations in one of five genes (ORC1, ORC4, ORC6, CDT1, and CDC6) of the pre-replication complex, involved in DNA-replication, are detected in approximately 67-78% of patients with MGS.
DNA-protein interaction dynamics at the Lamin B2 replication origin.
Giacca et al., Pisa, Italy. In Cell Cycle, 2014
In addition to the pre-RC component ORC4 and to the transcription factors USF and HOXC13, we found that 2 components of the AP-1 transcription factor, c-Fos and c-Jun, are also associated with the origin DNA during the late G1 phase of the cell cycle and that these factors interact with ORC4.
A role for DNA polymerase θ in the timing of DNA replication.
Hoffmann et al., Toulouse, France. In Nat Commun, 2013
We find that Pol θ binds to chromatin during early G1, interacts with the Orc2 and Orc4 components of the Origin recognition complex and that the association of Mcm proteins with chromatin is enhanced in G1 when Pol θ is downregulated.
Specification of DNA replication origins and genomic base composition in fission yeasts.
Antequera et al., Salamanca, Spain. In J Mol Biol, 2013
The information encoded in these replicators is interpreted by the Orc4 subunit of the ORC (origin recognition complex), which is unique among eukaryotes in that it contains a large domain harboring nine AT-hook subdomains that target ORC to a great variety of A+T-rich sequences along the chromosomes.
Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis.
Bongers et al., Nijmegen, Netherlands. In Eur J Hum Genet, 2012
compared with homozygous missense mutations, compound heterozygous mutations appeared to have a more severe effect on phenotype, causing more severe growth retardation in ORC4
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis.
Yongvanit et al., Khon Kaen, Thailand. In Parasitol Int, 2012
In preliminary results, significantly higher levels of OSBP2 and OSBPL-7 mRNA were seen in blood samples from cholangiocarcinoma patients than in healthy controls.
Mechanisms and pathways of growth failure in primordial dwarfism.
Jackson et al., Edinburgh, United Kingdom. In Genes Dev, 2011
Ten genes have now been identified for microcephalic primordial dwarfism, encoding proteins involved in fundamental cellular processes including genome replication (ORC1 [origin recognition complex 1], ORC4, ORC6, CDT1, and CDC6), DNA damage response (ATR [ataxia-telangiectasia and Rad3-related]), mRNA splicing (U4atac), and centrosome function (CEP152, PCNT, and CPAP).
Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.
Samuels et al., Halifax, Canada. In Nat Genet, 2011
identified three different mutations in the gene encoding ORC4, a component of the eukaryotic origin recognition complex, in five individuals with Meier-Gorlin syndrome
Mutations in the pre-replication complex cause Meier-Gorlin syndrome.
Jackson et al., Edinburgh, United Kingdom. In Nat Genet, 2011
We report here that individuals with this disorder show marked locus heterogeneity, and we identify mutations in five separate genes: ORC1, ORC4, ORC6, CDT1 and CDC6.
A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking.
Yang et al., Sydney, Australia. In J Cell Biol, 2011
ORP5 may cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes.
Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells.
Moore et al., London, United Kingdom. In Plos One, 2009
Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells.
The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing.
Stillman et al., New York City, United States. In Cell, 1995
Here we report the cloning of the genes encoding the 120 kDa (ORC1), 62 kDa (ORC3), and 56 kDa (ORC4) subunits of ORC and the reconstitution of the complete complex after expression of all six subunits in insect cells.
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