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ORAI calcium release-activated calcium modulator 1

Orai1, CRACM1
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Sim, STIM2, V1a, CAN, MAST
Papers using Orai1 antibodies
Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback
Tepikin Alexei V. et al., In Pflugers Archiv, 1994
... cDNA was then used as a template in PCR reactions to amplify full-length human STIM1 or ORAI1 using specific primers (below) containing restriction endonuclease sites to permit subsequent sub-cloning into the C-terminally tagging pEYFP-N1 vector (Clontech, Palo Alto, USA) or ...
Papers on Orai1
Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.
Feske et al., Thousand Oaks, United States. In J Immunol, Feb 2016
To investigate the role of ORAI1 in proinflammatory Th1 and Th17 cells and autoimmune diseases, we genetically and pharmacologically modulated ORAI1 function.
RefSOFI for Mapping Nanoscale Organization of Protein-Protein Interactions in Living Cells.
Zhang et al., San Diego, United States. In Cell Rep, Feb 2016
Using this strategy, termed reconstituted fluorescence-based SOFI (refSOFI), we investigated the interaction between the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the pore-forming channel subunit ORAI1, a crucial process in store-operated Ca(2+) entry (SOCE).
TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling.
Hogan et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, Jan 2016
The core elements of the pathway are the regulatory protein STIM1, located in the endoplasmic reticulum (ER) membrane, the calcium channel ORAI1 in the plasma membrane, and sites of close contact between the ER and the plasma membrane that permit the two proteins to interact.
Variations in ORAI1 Gene Associated with Kawasaki Disease.
Tanaka et al., Yokohama, Japan. In Plos One, Dec 2015
ORAI1 is a Ca2+ release activated Ca2+ (CRAC) channel mediating store-operated Ca2+ entry (SOCE) on the plasma membrane.
Diseases caused by mutations in ORAI1 and STIM1.
Feske et al., New York City, United States. In Ann N Y Acad Sci, Nov 2015
CRAC channels are composed of ORAI1 proteins located in the plasma membrane, which form its ion-conducting pore.
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca²⁺ influx.
Zhou et al., Houston, United States. In Nat Cell Biol, Oct 2015
Store-operated Ca(2+) entry mediated by dynamic STIM1-ORAI1 coupling represents a classical molecular event occurring at ER-PM junctions, but the protein composition and how previously unrecognized protein regulators facilitate this process remain ill-defined.
The STIM1-ORAI1 microdomain.
Hogan, Los Angeles, United States. In Cell Calcium, Oct 2015
The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction.
STIM and ORAI proteins in the nervous system.
Kraft, Leipzig, Germany. In Channels (austin), Oct 2015
Depletion of endoplasmic reticulum calcium stores activates STIM proteins which, in turn, bind and open calcium channels in the plasma membrane formed by the proteins ORAI1, ORAI2, and ORAI3.
Kalinichenko et al., In Urologiia, Jul 2015
These results indicate that genetic factors, in particular polymorphic variants of the ORAI calcium release-activated calcium modulator 1 (ORAI1, rs7135617), may affect multiple kidney stone formation in the Russian population.
Tweeters, Woofers and Horns: The Complex Orchestration of Calcium Currents in T Lymphocytes.
Jefferies et al., Vancouver, Canada. In Front Immunol, 2014
This process termed store-operated Ca(2+) entry (SOCE) involves the ER Ca(2+) sensing molecule, STIM1, and a pore-forming plasma membrane protein, ORAI1.
Stromal interaction molecules as important therapeutic targets in diseases with dysregulated calcium flux.
Brooks et al., Tampa, United States. In Biochim Biophys Acta, 2014
Upon activation, STIM1 interacts with a plasma membrane protein, ORAI1, to activate ORAI-containing calcium-selective plasma membrane channels.
Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer.
Prevarskaya et al., Villeneuve-d'Ascq, France. In Cancer Cell, 2014
By mimicking ORAI protein remodeling observed in primary tumors, we demonstrate in in vitro models that enhanced ORAI3 expression favors heteromerization with ORAI1 to form a novel channel.
Prostate cancer cells alter the nature of their calcium influx to promote growth and acquire apoptotic resistance.
Monteith, Brisbane, Australia. In Cancer Cell, 2014
Prostate cancer cells can undergo an oncogenic switch from a calcium influx pathway capable of inducing apoptosis involving ORAI1 channels to a pro-proliferative calcium influx pathway involving ORAI1/3 heteromeric channels.
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch.
Bautista et al., Berkeley, United States. In Cell, 2013
We identify the ORAI1/NFAT calcium signaling pathway as an essential regulator of TSLP release from keratinocytes, the primary epithelial cells of the skin.
An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry.
Hogan et al., Los Angeles, United States. In Nature, 2013
The STIM1-ORAI1 pathway of store-operated Ca(2+) entry is an essential component of cellular Ca(2+) signalling.
Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development.
Blair et al., Pittsburgh, United States. In Lab Invest, 2012
Micro-CT showed reduced cortical ossification and thinned trabeculae in Orai1(-/-) animals compared with controls; bone deposition was markedly decreased in the knockout mice. This suggests a previously unrecognized role for Orai1 within osteoblasts.
Overexpression of Orai1 and STIM1 proteins alters regulation of store-operated Ca2+ entry by endogenous mediators.
Bolotina et al., Boston, United States. In J Biol Chem, 2012
Variation of expression levels of Orai1 or STIM1 can significantly alter expression and role of some endogenous regulators of store operated calcium entry.
Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion.
Beech et al., Leeds, United Kingdom. In Circ Res, 2012
Suggest that PDGF has a nonclustering mechanism by which to activate Orai1 channels and maintain calcium stores replete.
Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).
Gwack et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2012
Data show that junctate (ASPH) is an interacting partner of Orai1-STIM1 complex.
The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population.
Hou et al., Kao-hsiung, Taiwan. In Scientificworldjournal, 2011
We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.
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