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Opsin 5

OPN-5, PGR-12
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: osteopontin, ACID, MMP-9, CD44, CD45
Papers on OPN-5
Expression of novel opsins and intrinsic light responses in the mammalian retinal ganglion cell line RGC-5. Presence of OPN5 in the rat retina.
Guido et al., Córdoba, Argentina. In Plos One, 2010
The presence of Opn5 in the ganglion cell layer of the rat retina suggests the existence of a novel type of photoreceptor cell.
UV-sensitive photoreceptor protein OPN5 in humans and mice.
Fukada et al., Tokyo, Japan. In Plos One, 2010
UV photoreceptor in human beings OPN5 triggers a UV-sensitive Gi-mediated signaling pathway in the mammalian tissues.
Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions.
Kunugi et al., Tokyo, Japan. In Neuropsychopharmacology, 2008
Genetic variation of the hNP gene may contribute to molecular mechanisms of bipolar disorder and some aspects of memory and intelligence.
RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer.
Kuo et al., Durham, United States. In Surgery, 2008
A luciferase construct coupled in line with OPN-5'-UTR and OPN 3'-UTR presented greater expression in HepG2 (P < .01
An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma.
Wang et al., Bethesda, United States. In Oncogene, 2007
One of these fragments (OPN-5 kDa, residues 167-210) induced low-metastatic HCC cellular invasion via CD44 receptors, which was effectively blocked by the addition of small peptides within the region of OPN-5 kDa.
Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach.
Dunning et al., Cambridge, United Kingdom. In Cancer Epidemiol Biomarkers Prev, 2006
Three SNPs showed no evidence for association and were not studied further, whereas seven SNPs (rs11571171, rs7116336, rs660149, rs10895068, rs500760, rs566351, and rs1042838) exhibited significant associations at P < 0.1 using either a heterogeneity or trend test and progressed to be genotyped in set 2. After both stages, only one SNP was significantly associated with an increased risk of breast cancer - the PGR-12 (rs1042638) V660L valine to leucine polymorphism [VL heterozygotes (odds ratio, 1.13; 95% confidence interval, 1.03-1.24)
Osteopontin posttranslational modifications, possibly phosphorylation, are required for in vitro bone resorption but not osteoclast adhesion.
Butler et al., Houston, United States. In Bone, 2002
We purified two forms of OPN (OPN-2 and OPN-5), which differ in the level of phosphorylation, and compared their activities.
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