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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Oligodendrocyte myelin glycoprotein

OMgp, O-MG
Top mentioned proteins: Nogo, MAG, CD45, NgR, CAN
Papers on OMgp
Experimental and Clinical Advances in Immunotherapy Strategies for Spinal Cord Injury Target on MAIs and Their Receptors.
Wang et al., Chongqing, China. In Curr Pharm Des, Jan 2016
UNASSIGNED: In the injured adult mammalian central nervous system (CNS), the failure of axonal regeneration is thought to be attributed, at least in part, to various myelin-associated inhibitors (MAIs), such as Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp) around the damaged site.
Axonal regeneration inhibitors: emerging therapeutic options.
Kozak et al., Toruń, Poland. In Acta Neurol Belg, Dec 2015
The paper presents the role of Nogo-A, MAG and OMgp proteins in the inhibition of central nervous system regeneration, and their potential clinical significance.
The Neural Stem Cell Microenvironment: Focusing on Axon Guidance Molecules and Myelin-Associated Factors.
Jin et al., Wenzhou, China. In J Mol Neurosci, Aug 2015
Recent reports have implicated three myelin-derived inhibitors, NogoA, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp), as well as several axon guidance molecules as regulators of NSC survival, proliferation, migration, and differentiation.
Increased migration of olfactory ensheathing cells secreting the Nogo receptor ectodomain over inhibitory substrates and lesioned spinal cord.
del Río et al., Barcelona, Spain. In Cell Mol Life Sci, Jul 2015
Results indicate that engineered cells migrate longer distances than unmodified OECs over myelin or oligodendrocyte-myelin glycoprotein (OMgp)-coated substrates.
Glycans of myelin proteins.
Grandis et al., Stockholm, Sweden. In J Neurosci Res, 2015
The MAG has 10 glycosylation sites; the glycoprotein OMgp has 11 glycosylation sites.
Insights into the physiological role of CNS regeneration inhibitors.
Giger et al., Ann Arbor, United States. In Front Mol Neurosci, 2014
Prototypic CNS regeneration inhibitors are broadly expressed in the healthy and injured brain and spinal cord and include myelin-associated glycoprotein (MAG), the reticulon family member NogoA, oligodendrocyte myelin glycoprotein (OMgp), and chondroitin sulfate proteoglycans (CSPGs).
Immunotherapy strategies for spinal cord injury.
Qiu et al., Chongqing, China. In Curr Pharm Biotechnol, 2014
In addition, myelinassociated inhibitors (MAIs) in the injured spinal cord, such as Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte- myelin glycoprotein (OMgp) are known to prevent axonal regeneration through their co-receptors, and to trigger demyelinating autoimmunity through T cell-mediated harmful autoimmune response.
α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction.
Waltho et al., Sheffield, United Kingdom. In Proc Natl Acad Sci U S A, 2014
Its equatorial hydroxyl groups are hydrogen-bonded directly to the enzyme rather than indirectly via water molecules as in step 2. The (C)O-P bond orientation for binding the phosphate in the inert phosphate site differs by ∼ 30° between steps 1 and 2. By contrast, the orientations for the axial O-Mg-O alignment for the TSA of the phosphoryl group in the catalytic site differ by only ∼ 5°, and the atoms representing the five phosphorus-bonded oxygens in the two transition states (TSs) are virtually superimposable.
Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action.
Lee et al., Madrid, Spain. In Plos Biol, 2014
The p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily, is required as a co-receptor for the Nogo receptor (NgR) to mediate the activity of myelin-associated inhibitors such as Nogo, MAG, and OMgp.
Axon growth inhibition by RhoA/ROCK in the central nervous system.
Yamashita et al., Ōsaka, Japan. In Front Neurosci, 2013
The RhoA/ROCK pathway mediates the effects of myelin-associated axon growth inhibitors-Nogo, myelin-associated glycoprotein (MAG), oligodendrocyte-myelin glycoprotein (OMgp), and repulsive guidance molecule (RGM).
Oligodendrocyte differentiation and myelination defects in OMgp null mice.
Mi et al., Cambridge, United States. In Mol Cell Neurosci, 2011
study provided in vitro and in vivo evidence that endogenous OMgp plays an important role in oligodendrocyte differentiation and myelination
Learning disability and oligodendrocyte myelin glycoprotein (OMGP) gene in neurofibromatosis type 1.
Ayter et al., Ankara, Turkey. In Turk J Pediatr, 2011
The results do not support a relationship between the OMGP gene and the learning disability phenotype observed in neurofibromatosis type 1.
Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon.
Del Río et al., Barcelona, Spain. In Cereb Cortex, 2010
Expression of Omg protein in the embryonic mouse telencephalon indicates Omg has a role in axonal target specification and synaptic plasticity.
Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice.
Zheng et al., San Diego, United States. In Neuron, 2010
While myelin-derived axon growth inhibitor OMG may modulate axon sprouting, it does not play a major role in central nervous system axon regeneration failure.
Generation of an OMgp allelic series in mice.
Zheng et al., San Diego, United States. In Genesis, 2009
This allelic series will aid in the study of OMgp in adult CNS axon regeneration using mouse models of spinal cord injury.
PirB is a functional receptor for myelin inhibitors of axonal regeneration.
Tessier-Lavigne et al., San Francisco, United States. In Science, 2008
Three proteins found in myelin--Nogo, MAG, and OMgp--inhibit axon regeneration in vitro and bind to the glycosylphosphatidylinositol-anchored Nogo receptor (NgR).
Glial membranes at the node of Ranvier prevent neurite outgrowth.
Colman et al., New York City, United States. In Science, 2006
Proteomic analysis of these membranes revealed several inhibitors of neurite outgrowth, including the oligodendrocyte myelin glycoprotein (OMgp).
Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor.
Strittmatter et al., New Haven, United States. In Science, 2005
Thus, physiological NgR signaling from myelin-derived Nogo, MAG, and OMgp consolidates the neural circuitry established during experience-dependent plasticity.
P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.
He et al., Boston, United States. In Nature, 2002
In inhibiting neurite outgrowth, several myelin components, including the extracellular domain of Nogo-A (Nogo-66), oligodendrocyte myelin glycoprotein (OMgp) and myelin-associated glycoprotein (MAG), exert their effects through the same Nogo receptor (NgR).
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.
He et al., Boston, United States. In Nature, 2002
Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.
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