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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Transmembrane and tetratricopeptide repeat containing 1

OLF, GNAL, Galphaolf, Arg99
alpha subunit of GTP-binding protein, first identified in the olfactory system; implicated in the signal transduction for odorant and visual stimuli and for one or more hormones/neurotransmitters [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: EBF, CAN, ACID, HAD, ATPase
Papers on OLF
Novel GNAL mutation with intra-familial clinical heterogeneity: Expanding the phenotype.
Garavaglia et al., Milano, Italy. In Parkinsonism Relat Disord, Jan 2016
INTRODUCTION: Mutations in GNAL have been associated with adult-onset cranio-cervical dystonia, but a limited number of cases have been reported so far and the clinical spectrum associated with this gene still needs to be fully characterized.
Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.
Comoletti et al., New Brunswick, United States. In Structure, Oct 2015
By isothermal titration calorimetry, we determined that only the olfactomedin (OLF) domain of LPHN3 is necessary for FLRT3 association.
Isolated and combined dystonia syndromes - an update on new genes and their phenotypes.
Bhatia et al., London, United Kingdom. In Eur J Neurol, Apr 2015
Some genes, such as ANO3, GNAL and CIZ1, have been discovered for isolated dystonia, but they are probably not a common cause of classic cervical dystonia.
Genome-Wide Mapping of Collier In Vivo Binding Sites Highlights Its Hierarchical Position in Different Transcription Regulatory Networks.
Vincent et al., Toulouse, France. In Plos One, 2014
Collier, the single Drosophila COE (Collier/EBF/Olf-1) transcription factor, is required in several developmental processes, including head patterning and specification of muscle and neuron identity during embryogenesis.
Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies.
Lieberman et al., Atlanta, United States. In Plos One, 2014
Olfactomedin (OLF) domains are found within extracellular, multidomain proteins in numerous tissues of multicellular organisms.
Identification of Putative Natriuretic Hormones Isolated from Human Urine.
Kramer, Bonn, Germany. In Front Endocrinol (lausanne), 2014
This brief review describes some representative methodological approaches to the isolation of putative endogenous inhibitors of epithelial sodium transport - i.e., as ouabain-like factors (OLF) that inhibit the sodium transport enzyme Na-K-ATPase or inhibit the epithelial sodium channel (ENaC).
Characterization of Burkholderia pseudomallei protein BPSL1375 validates the Putative hemolytic activity of the COG3176 N-Acyltransferase family.
Firdaus-Raih et al., Kuala Selangor, Malaysia. In Bmc Microbiol, 2014
Sequence alignments identified seven highly conserved residues (Arg54, Phe58, Asp75, Asp78, Arg99, Glu132 and Arg135), of which several have been implicated with N-acyltransferase activity in previously characterized examples.
Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp.
Gottschalk et al., Würzburg, Germany. In Nat Commun, 2014
Via co-expressed CNG channels (OLF in oocytes, TAX-2/4 in C. elegans muscle), BeCyclOp photoactivation induces a rapid conductance increase and depolarization at very low light intensities.
Inherited isolated dystonia: clinical genetics and gene function.
Dauer, Ann Arbor, United States. In Neurotherapeutics, 2014
Here, I review the clinical genetics and cell biology of three forms of inherited dystonia for which the causative mutation is known: DYT1 (TOR1A), DYT6 (THAP1), DYT25 (GNAL).
Dystonia: an update on phenomenology, classification, pathogenesis and treatment.
Bhatia et al., Heidelberg, Germany. In Curr Opin Neurol, 2014
The recently discovered genes ANO3, GNAL and CIZ1 appear not to be a common cause of adult-onset cervical dystonia.
Genetics in dystonia.
Klein, Lübeck, Germany. In Parkinsonism Relat Disord, 2014
Confirmed genes for isolated dystonias include TOR1A/DYT1; THAP1/DYT6; GNAL/DYT25.
Mutations in GNAL cause primary torsion dystonia.
Ozelius et al., New York City, United States. In Nat Genet, 2013
Using exome sequencing in two families with PTD, we identified a new causative gene, GNAL, with a nonsense mutation encoding p.Ser293* resulting in a premature stop codon in one family and a missense mutation encoding p.Val137Met in the other.
Gα(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia.
Hervé et al., Paris, France. In J Neurosci, 2012
This study demonistrated that Galphaolf upregulation in dyskinetic mice
XLGαolf regulates expression of p27Kip1 in a CSN5 and CDK2 dependent manner.
Saito et al., Ōsaka, Japan. In Biochem Biophys Res Commun, 2012
these findings provide important clues to understanding physiological functions of XLGalpha(olf).
Subcellular localization of a novel G protein XLGalpha(olf).
Kaneko et al., Ōsaka, Japan. In Biochem Biophys Res Commun, 2009
This study provides important clues toward understanding physiological functions of XLGalpha(olf).
The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons.
Usiello et al., Napoli, Italy. In Mol Cell Neurosci, 2008
The absence of Rhes modulates cAMP/PKA signalling in both striatopallidal and striatonigral projection neurons by increasing Golf protein levels and, in turn, influencing motor responses challenged by dopaminergic agonist/antagonist.
Investigation of the G protein subunit Galphaolf gene (GNAL) in attention deficit/hyperactivity disorder.
Barr et al., Toronto, Canada. In J Psychiatr Res, 2008
We hypothesized that the G(s)-like subunit Galpha(olf), expressed in D1-rich areas of the brain, contributes to the genetic susceptibility of ADHD. We examined the inheritance pattern of 12 GNAL polymorphisms in 258 nuclear families.
OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
Massagué et al., New York City, United States. In Cell, 2000
Previously implicated as a transcriptional partner of Olf-1/EBF in olfactory epithelium and lymphocyte development in the rat, OAZ fulfills this role through clusters of fingers that are separate from the BMP signaling module.
Failure of B-cell differentiation in mice lacking the transcription factor EBF.
Grosschedl et al., San Francisco, United States. In Nature, 1995
Various non-lymphoid tissues that express EBF are apparently normal in homozygous mutant mice, including olfactory neurons in which EBF was identified as Olf-1 (refs 5, 6).
Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast.
Reed et al., Baltimore, United States. In Nature, 1993
A novel genetic selection in yeast has been used to isolate a complementary DNA for the transcriptional activator, Olf-1, which binds to the regulatory sequences of several olfactory-specific genes.
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