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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

OGG1 8-oxoguanine DNA glycosylase

OGG1, 8-oxoguanine-DNA glycosylase
Top mentioned proteins: CAN, XRCC1, AGE, POLYMERASE, HAD
Papers using OGG1 antibodies
Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer
Reiter Russel J. et al., In Molecular Biology Reports, 2002
... hOGG1 was purchased from New England Biolabs (Herts, UK) ...
Papers on OGG1
Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity.
Brasier et al., Galveston, United States. In J Innate Immun, Feb 2016
Nuclear ROS oxidize guanine bases to produce mutagenic 8-oxoguanine, a lesion excised by 8-oxoguanine DNA glycosylase1/AP-lyase (OGG1).
Transcription Factors and DNA Repair Enzymes Compete for Damaged Promoter Sites.
Strauss et al., United States. In J Biol Chem, Feb 2016
We incubated 39-mer CRE-containing ds oligonucleotides with recombinant CREB1 alone or with UNG2 or OGG1, followed by electrophoretic mobility shift assay (EMSA).
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Bjørås et al., Oslo, Norway. In Cell Rep, Jan 2016
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline.
Association of XRCC1 and OGG1 DNA repair gene polymorphisms with rheumatoid arthritis in Egyptian patients.
Abdel Galil et al., Az Zaqāzīq, Egypt. In Gene, Jan 2016
In this study, we investigated the association of two XRCC1 (X-ray repair cross-complementing group 1) (rs25487 and rs25489) gene polymorphisms and two OGG1 (8-oxoguanine glycosylase 1) gene polymorphisms (rs159153 and rs3219008) with the susceptibility to RA in 320 Egyptians individuals (160 RA patients and 160 controls).
Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study.
Kayani et al., Islamabad, Pakistan. In Plos One, Dec 2015
The expression of mitochondrial tumor suppressor genes (SIRT3, SIRT4 and MTUS1), mitochondrial DNA repair gene (OGG1-2a) and a proliferation marker (Ki-67) was studied in a study cohort of 120 HNSCC patients and controls with reverse transcriptase polymerase chain reaction (RT-PCR) and real-time PCR (qPCR) in order to determine the potential prognostic significance of these genes.
Current concept of photocarcinogenesis.
Nishisgori, Kōbe, Japan. In Photochem Photobiol Sci, Oct 2015
It has been shown that in Ogg1 knockout mice which are deficient in repairing 8-oxo-7, 8-dihydroguanine (8-oxoG), UVB irradiation up-regulates the inflammatory gene, implying that 8-oxoG is involved in triggering inflammation.
Germ line polymorphisms as predictive markers for pre-surgical radiochemotherapy in locally advanced rectal cancer: a 5-year literature update and critical review.
Gusella et al., Padova, Italy. In Eur J Clin Pharmacol, May 2015
RESULTS: Ten original research articles were found, reporting promising results for some candidate genes in drug metabolism (TYMS, MTHFR), DNA repair (XRCC1, OGG1, CCND1) and inflammation (SOD2, TGFB1)/immunity (IL13) pathways, but with no firm conclusion.
Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.
Boothman et al., Dallas, United States. In Sci Rep, 2014
In contrast, depleting OGG1 N-glycosylase spared cells from ß-lap-induced lethality and blunted PARP1 hyperactivation.
The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis.
Kamp et al., Chicago, United States. In Int J Mol Sci, 2014
We focus on the emerging role for AEC mtDNA damage repair by 8-oxoguanine DNA glycosylase (OGG1) and mitochondrial aconitase (ACO-2) in maintaining mtDNA integrity which is important in preventing AEC apoptosis and asbestos-induced pulmonary fibrosis in a murine model.
Molecular basis of asbestos-induced lung disease.
Kamp et al., China. In Annu Rev Pathol, 2013
We review mitochondrial DNA (mtDNA)-damage and -repair mechanisms, focusing on 8-oxoguanine DNA glycosylase, as well as cross talk between reactive oxygen species production, mtDNA damage, p53, OGG1, and mitochondrial aconitase.
DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression.
Avvedimento et al., Avellino, Italy. In Science, 2008
Localized demethylation produces hydrogen peroxide, which modifies the surrounding DNA and recruits 8-oxoguanine-DNA glycosylase 1 and topoisomeraseIIbeta, triggering chromatin and DNA conformational changes that are essential for estrogen-induced transcription.
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.
McMurray et al., Rochester, United States. In Nature, 2007
Here we show that the age-dependent somatic mutation associated with Huntington's disease occurs in the process of removing oxidized base lesions, and is remarkably dependent on a single base excision repair enzyme, 7,8-dihydro-8-oxoguanine-DNA glycosylase (OGG1).
8-Hydroxyguanine: From its discovery in 1983 to the present status.
Nishimura, Tsukuba, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2006
Lastly, our own recent work is summarized involving a one-year carcinogenesis study of Ogg1 (the gene for 8-OH-G specific glycosylase/AP lyase) knockout mice that have been exposed to oxidative stress.
Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.
Tomlinson et al., London, United Kingdom. In N Engl J Med, 2003
Subgroups were analyzed for changes in the related genes MTH1 and OGG1.
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.
Prakash et al., Galveston, United States. In Nat Genet, 2000
In Saccharomyces cerevisiae, deletion of OGG1, encoding a DNA glycosylase that functions in the removal of 8-oxoG when paired with C, causes an increase in the rate of G:C to T:A transversions.
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