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POU class 2 homeobox 2

Oct-2, hOCT2, SLC22A2, rOCT2
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: OCT, ACID, Oct-1, CAN, V1a
Papers on Oct-2
The MATE1 rs2289669 polymorphism affects the renal clearance of metformin following ranitidine treatment.
Chung et al., In Int J Clin Pharmacol Ther, Feb 2016
PURPOSE: Human multidrug and toxin extrusion member 1 (MATE1, SLC47A1) and Organic Cation Transporter 2 (OCT2, SLC22A2) play important roles in the renal elimination of various pharmacologic agents, including the anti-diabetic drug metformin.
A PET Tracer For Renal Organic Cation Transporters, 11C-metformin: Radiosynthesis and Preclinical Proof-of-Concept Studies.
Frøkiær et al., Århus, Denmark. In J Nucl Med, Feb 2016
Metformin is a widely used drug and targets OCT-type 2 (OCT2) located in PT.
Comprehensive chemical profiling of Picrorhiza kurroa Royle ex Benth using NMR, HPTLC and LC-MS/MS techniques.
Ahuja et al., India. In Comb Chem High Throughput Screen, Feb 2016
Primary and secondary metabolites were unambiguously identified along with a new report of monoterpenic glycoside (1-β-D-glucopyranosyl)-8-hydroxy-3,7-dimethyl-oct-2(E),6(E)-dienoate) in P. Kurroa.
The non-metabolized β-blocker nadolol is a substrate of OCT1, OCT2, MATE1, MATE2-K and P-glycoprotein, but not of OATP1B1 and OATP1B3.
Fromm et al., In Mol Pharm, Jan 2016
We therefore investigated nadolol as a potential substrate of the hepatic uptake transporters OATP1B1, OATP1B3, and OCT1 and of the renal transporters OCT2, MATE1, and MATE2-K expressed in HEK cells.
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.
Shu et al., Nashville, United States. In Sci Rep, Dec 2015
We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI.
Treatment-resistant depression: are animal models of depression fit for purpose?
Belzung et al., Swansea, United Kingdom. In Psychopharmacology (berl), Oct 2015
Currently, the most promising are the Wistar-Kyoto (WKY) and congenital learned helplessness (cLH) rat strains, the high anxiety behaviour (HAB) mouse strain and the CB1 receptor knockout and OCT2 null mutant mouse strains.
Hodgkin Lymphoma of the Nasopharynx: Case Report with Review of the Literature.
McBee et al., Pittsburgh, United States. In Head Neck Pathol, Sep 2015
Immunohistochemical analysis revealed CD15, CD30, OCT-2, BOB.1, and MUM-1 expression by the neoplastic cells and a lack of expression of CD45, CD20, CD3, EMA, and EBER.
Intratubular germ cell neoplasia of the testis: a brief review.
Akhtar et al., Riyadh, Saudi Arabia. In Adv Anat Pathol, May 2015
The tumor cells manifest many of the proteins normally expressed by mature sperms such as VASA, SSX2, and occasionally OCT2.
Role of organic cation transporters in drug-drug interaction.
Koepsell, Würzburg, Germany. In Expert Opin Drug Metab Toxicol, 2014
INTRODUCTION: Organic cation transporters OCT1, OCT2 and OCT3 expressed in the small intestine, liver, brain and other organs play important roles in absorption, excretion and distribution of cationic drugs.
Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug-Drug Interactions.
Trejtnar et al., Hradec Králové, Czech Republic. In Front Pharmacol, 2014
The goal of this study was to investigate the potential of ETV to interact in vitro with the renal SLC transporters hOAT1, hOCT2, hCNT2 and hCNT3.
Renal tubular transporter-mediated interactions of HIV drugs: implications for patient management.
Domingo et al., Alacant, Spain. In Aids Rev, 2014
While rilpivirine and dolutegravir inhibit mainly the renal transporter OCT2 in the basolateral membrane of the proximal tubular cell, cobicistat predominantly inhibits the renal transporter MATE1 in the luminal membrane.
Transporters and drug-drug interactions: important determinants of drug disposition and effects.
Fromm et al., Nürnberg, Germany. In Pharmacol Rev, 2013
This review will summarize in particular clinically observed drug-drug interactions attributable to inhibition or induction of intestinal export transporters [P-glycoprotein (P-gp), breast cancer resistance protein (BCRP)], to inhibition of hepatic uptake transporters [organic anion transporting polypeptides (OATPs)], or to inhibition of transporter-mediated [organic anion transporters (OATs), organic cation transporter 2 (OCT2), multidrug and toxin extrusion proteins (MATEs), P-gp] renal secretion of xenobiotics.
Functional significance of conserved cysteines in the human organic cation transporter 2.
Wright et al., Halifax, Canada. In Am J Physiol Renal Physiol, 2012
Conserved cysteines in the human organic cation transporter 2 (hOCT2), namely the six cysteines in the long extracellular loop (loop cysteines) and C474 in transmembrane helix 11, are important for plasma membrane targeting.
Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients.
Zhou et al., Jinan, China. In Food Chem Toxicol, 2012
results suggested that SLC22A2 gene polymorphism 808 G/T and cimetidine could attenuate cisplatin nephrotoxicity in Chinese cancer patients
Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.
Sparreboom et al., Münster, Germany. In Clin Cancer Res, 2012
OCT2 plays a decisive role in the renal secretion of creatinine. This process can be inhibited by OCT2 substrates, which impair the usefulness of creatinine as a marker of renal function.
Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition.
Liu et al., Pusan, South Korea. In Plos One, 2011
tryptophan can serve as one of the endogenous substrate for the OCT2 as well as a biomarker candidate indicating the variability of the transport activity of OCT2.
Immunohistochemical expression of Mum-1, Oct-2 and Bcl-6 in systemic anaplastic large cell lymphomas.
Uner et al., Ankara, Turkey. In Tumori, 2011
Half of the cases displayed Oct-2 expression (15/30 cases) of systemic anaplastic large-cell lymphoma measured by tissue microarray immunohistochemistry.
New loci associated with kidney function and chronic kidney disease.
Fox et al., Baltimore, United States. In Nat Genet, 2010
Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3).
Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.
Sharp et al., Cambridge, United States. In Immunity, 1999
Targeted disruption of either of the B cell-specific transcription factors Oct-2 or OCA-B/BOB-1/OBF-1 dramatically affects B cell terminal differentiation.
Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif.
Baltimore et al., Cambridge, United States. In Science, 1988
Thus, this cDNA derives from a gene (oct-2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell-specific transcription factor exists and its amount is controlled through messenger RNA availability.
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