GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
POU domain, class 2, associating factor 1
OCA-B, OBF-1, Bob1, BOB.1, OBF.1
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Top mentioned proteins:
Oct-2, OCT, GPR15, Izumo, Oct-1
Papers on
OCA-B
Primary Cutaneous Follicle Center Lymphomas Expressing BCL2 Protein Frequently Harbor BCL2 Gene Break and May Present 1p36 Deletion: A Study of 20 Cases.
New
Créteil, France. In Am J Surg Pathol, Jan 2016
To investigate these issues and to further characterize PCFCL, we studied a series of 25 CFLs without any extracutaneous disease at diagnosis, selected on the basis of BCL2 protein expression using 2 BCL2 antibodies (clones 124 and E17) and BOB1/BCL2 double immunostaining.
NF-κB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells.
New
Ulm, Germany. In Eur J Immunol, Dec 2015
The transcriptional co-activator BOB.1/OBF.1 is crucial for Octamer-driven transcription in B cells.
Oct1 and OCA-B are selectively required for CD4 memory T cell function.
New
Salt Lake City, United States. In J Exp Med, Dec 2015
We find that the transcription factor Oct1 and its cofactor OCA-B are selectively required for the in vivo generation of CD4(+) memory T cells.
Distinguishing Classical Hodgkin Lymphoma, Gray Zone Lymphoma, and Large B-cell Lymphoma: A Proposed Scoring System.
New
Chapel Hill, United States. In Appl Immunohistochem Mol Morphol, Nov 2015
MATERIALS AND METHODS: This system emphasized known criteria used to diagnose CHL that are rare in B-cell lymphoma (BCL) [CD15+, CD45-, CD20- or weak/variable, PAX5+ (weak or moderate), CD79a-, OCT-2-/BOB.1- or OCT-2+/BOB.1- or OCT-2-/BOB.1+,
Hodgkin Lymphoma of the Nasopharynx: Case Report with Review of the Literature.
Review
New
Pittsburgh, United States. In Head Neck Pathol, Sep 2015
Immunohistochemical analysis revealed CD15, CD30, OCT-2, BOB.1, and MUM-1 expression by the neoplastic cells and a lack of expression of CD45, CD20, CD3, EMA, and EBER.
[Primary pulmonary Hodgkin lymphoma diagnosed by CT-guided percutaneous biopsy].
In Rinsho Ketsueki, 2015
Immunological staining revealed the specimens to be CD30- and PAX5-positive, with large dysplastic lymphocytes negative for Bob-1 and Oct-2 with a background of small lymphocytes and eosinophils.
Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment.
Review
New York City, United States. In Clin Lymphoma Myeloma Leuk, 2014
It is characterized histologically by presence of lymphohistiocytic cells which have B-cell phenotype, are positive for CD19, CD20, CD45, CD79a, BOB.1, Oct.2, and negative for CD15 and CD30.
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.
Impact
Boston, United States. In Cancer Cell, 2014
Functional study of genes marked by super-enhancers identifies DLBCLs dependent on OCA-B and suggests a strategy for discovering unrecognized cancer dependencies.
Epstein-Barr virus-positive diffuse large B-cell lymphomas of the elderly.
Review
Tübingen, Germany. In Adv Anat Pathol, 2011
Strong, homogeneous expression of B-cell markers, including transcription factors OCT2 and BOB.1, and lack of CD15 support a diagnosis of EBV+ DLBCL.
Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication.
GeneRIF
New York City, United States. In Mol Cell, 2011
Data show that Igh 3' enhancer-bound OCA-B and promoter-bound TFII-I mediate promoter-enhancer interactions, in both cis and trans, that are important for Igh transcription.
B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma.
GeneRIF
Timişoara / Temesvár, Romania. In Rom J Morphol Embryol, 2010
Twenty-two cases of nodular lymphocyte predominant Hodgkin lymphoma were studied for the immunohistochemical expression of Pax-5, Oct-2, BOB.1, Bcl-6 protein and MUM1/IRF-4.
Evaluation of CARMA1/CARD11 and Bob1 as candidate genes in common variable immunodeficiency.
GeneRIF
Brescia, Italy. In J Investig Allergol Clin Immunol, 2010
genetic polymorphism is associated with common variable immunodeficiency
Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma presenting as an isolated nasopharyngeal mass: a case report and review of literature.
Review
San Diego, United States. In Int J Clin Exp Pathol, 2010
Histologically, the tumor cells exhibited plasmablastic morphology with expression of Bob-1, CD4, CD10, CD45, CD56, CD138, EMA, MUM1, Oct-2, and kappa immunoglobulin light chain, but negative for CD20, CD30, CD79a, PAX-5, and lambda.
B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology.
Review
Milano, Italy. In Hum Pathol, 2010
Alternatively, these cases may resemble primary mediastinal large B-cell lymphoma but contain tumor cells resembling Reed-Sternberg cells and displaying an aberrant phenotype such as CD20(-), CD15(-/+) CD45(+), CD30(+), Pax5(+), OCT2(+/-), and BOB1(+/-).
OCT-2 expression and OCT-2/BOB.1 co-expression predict prognosis in patients with newly diagnosed acute myeloid leukemia.
GeneRIF
Cleveland, United States. In Leuk Lymphoma, 2010
On multivariate analysis, co-expression of OCT-2/BOB.1 remained predictive for achievement of complete remission and increased risk of relapse.
BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin's lymphoma from primary mediastinal large B-cell lymphoma.
GeneRIF
Basel, Switzerland. In Histopathology, 2010
BOB.1 may be helpful marker in the differential diagnosis of classical Hodgkin's lymphoma and primary mediastinal B-cell lymphoma
Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development.
Impact
GeneRIF
New York City, United States. In Cell, 2006
Results suggest that OCA-B is required for pre-BCR and BCR signaling at multiple stages of B cell development through its nontranscriptional regulation of SYK.
OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes.
Impact
GeneRIF
New York City, United States. In Cell, 2002
OcaB is essential for V(D)J recombination of a subset of Igkappa genes. We show that OcaB modulates recombination by directly enhancing Igkappa gene transcription in vivo.
Identification and characterization of a novel OCA-B isoform. implications for a role in B cell signaling pathways.
Impact
New York City, United States. In Immunity, 2001
OCA-B is a B lymphocyte-specific transcription coactivator that mediates tissue- and stage-restricted transcription of immunoglobulin genes.
Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration.
Impact
United States. In Cell, 2001
The POU dimer formed on the PORE (ATTTGAAATGCAAAT) can recruit the transcriptional coactivator OBF-1, whereas POU dimers formed on the consensus MORE (ATGCATATGCAT) or on MOREs from immunoglobulin heavy chain promoters (AT[G/A][C/A]ATATGCAA) fail to interact.
