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Solute carrier organic anion transporter family, member 1B1

OATP1B1, Oatp2, SLCO1B1, OATP-C, SLC21A6
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: OATP, OATP1B3, ACID, CAN, HAD
Papers on OATP1B1
Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians.
Kawai et al., Tokyo, Japan. In Br J Clin Pharmacol, Feb 2016
Intrinsic factors (polymorphism of UGT1A1 for moxifloxacin, SLCO1B1 for simvastatin, and CYP2C9 for meloxicam) were also examined.
Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine.
Yue et al., In Mol Pharm, Feb 2016
Decreased OATP1B1 transport activity is often associated with increased systemic exposure of statins and statin-induced myopathy.
Mixed effects of OATP1B1, BCRP and NTCP polymorphisms on the population pharmacokinetics of pravastatin in healthy volunteers.
Chen et al., Shenyang, China. In Xenobiotica, Feb 2016
This study aims to investigate the effects of genetic polymorphisms in OATP1B1, BCRP and NTCP on pravastatin population pharmacokinetics in healthy Chinese volunteers using a non-linear mixed-effect modelling (NONMEM) approach.
Seventeen years of statin pharmacogenetics: a systematic review.
Maitland-van der Zee et al., Utrecht, Netherlands. In Pharmacogenomics, Jan 2016
In addition, six genome-wide association studies of LDL-C response identified common SNPs in APOE, LPA, SLCO1B1, SORT1 and ABCG2 at genome-wide significance.
Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence Display Hepatic Differentiation Characteristics in Monolayer and Organotypical Spheroid Cultures.
K├╝pper et al., Senftenberg, Germany. In Cell Biol Int, Jan 2016
Additionally, transcripts for phase II liver enzymes and transporter proteins OATP-C, MRP2, Oct1 and BSEP were present in HepaFH3.
Diclofenac and its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.
Rodrigues et al., Bristol, United Kingdom. In Drug Metab Dispos, Jan 2016
DF was identified as a substrate of organic anion transporter 2 only (OAT2, Km = 46.8
Insights into the diagnosis of hepatocellular carcinomas with hepatobiliary MRI.
Pastor et al., Clichy, France. In J Hepatol, Dec 2015
When tumour cells lose organic anion transporting polypeptides (OATP1B1/B3) in cell membranes facing sinusoidal blood, tumours appear hypointense (decreased contrast agent concentrations) in comparison to surrounding normal or cirrhotic liver that retains OATP1B1/B3 expression.
Pharmacogenetic biomarkers predictive of the pharmacokinetics and pharmacodynamics of immunosuppressive drugs.
Haufroid et al., Brussels, Belgium. In Ther Drug Monit, Nov 2015
However, despite some evidence of clear associations between polymorphisms in genes encoding metabolizing enzymes (CYP3A4/3A5, UGT1A9) or drug transporters (ABCB1, ABCC2, SLCO1B1) and pharmacokinetics of several immunosuppressive drugs, pre-emptive genotyping and selection of the optimal starting dose based on the genetic background of the patient is still rarely performed in clinical practice.
Interaction of Drug or Food with Drug Transporters in Intestine and Liver.
Tamai et al., Kanazawa, Japan. In Curr Drug Metab, 2014
Among those transporters, this review will focus on PEPT1 and OATP2B1 as influx transporter and p-glycoprotein (P-gp) and BCRP as efflux transporter in intestinal epithelial cells, and on OATP1B1 and 1B3 as influx transporter and MRP2 as efflux transporter in hepatocytes, respectively, because drug-drug (DDI) and -food (DFI) interactions on these transporter are considered to affect bioavailability of their substrate drugs.
Low-Dose Aspirin-Associated Upper and Mid Gastrointestinal Tract Damage and Gene Polymorphism.
Nishio et al., Kurashiki, Japan. In Curr Pharm Des, 2014
In our previous Japanese study, SLCO1B1 521TT genotype and the SLCO1B1 *1b haplotype were significantly associated with the risk of peptic ulcer and ulcer bleeding in patients taking LDA, especially in the patients with angiotensin converting enzyme inhibitor (ACEI), angiotensin type 1 receptor blocker (ARB), or statin co-treatment.
Pharmacogenetics and cardiovascular disease--implications for personalized medicine.
Cavallari et al., Gainesville, United States. In Pharmacol Rev, 2013
The body of literature that has led to the clinical implementation of CYP2C19 genotyping for clopidogrel, VKORC1, CYP2C9; and CYP4F2 for warfarin; and SLCO1B1 for statins is comprehensively described.
SLCO1B1 *15 haplotype is associated with rifampin-induced liver injury.
Chen et al., Chongqing, China. In Mol Med Report, 2012
the OATP1B1 *15 haplotype is an important predisposing factor for rifampin-induced liver injury.
Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy.
Wang et al., Hangzhou, China. In Arch Gynecol Obstet, 2012
OATP1B1 mRNA was detected in intrahepatic cholestasis of pregnancy placentas and control placentas, but protein expression of OATP1B1 was not found in any of the placentas.
SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians.
Hutz et al., Porto Alegre, Brazil. In Clin Chem Lab Med, 2012
SLCO1B1 c.388A>G polymorphism could play a role in the inter-individual variation of clinical response to simvastatin in Brazilians
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.
Schinkel et al., Amsterdam, Netherlands. In J Clin Invest, 2012
Data show that Rotor syndrome was linked to mutations predicted to cause complete and simultaneous deficiencies of the organic anion transporting polypeptides OATP1B1 and OATP1B3.
Identification of amino acids essential for estrone-3-sulfate transport within transmembrane domain 2 of organic anion transporting polypeptide 1B1.
Hong et al., Guangzhou, China. In Plos One, 2011
amino acids essential for estrone-3-sulfate transport function of OATP1B1
Using genome-wide association studies to identify genes important in serious adverse drug reactions.
Daly, Newcastle upon Tyne, United Kingdom. In Annu Rev Pharmacol Toxicol, 2011
For simvastatin-related myotoxicity, a strong association with SLCO1B1, which encodes the hepatic statin uptake transporter, has been detected.
The expression and function of organic anion transporting polypeptides in normal tissues and in cancer.
Hagenbuch et al., Kansas City, United States. In Annu Rev Pharmacol Toxicol, 2011
Members of the OATP1 and OATP2 families are functionally the best-characterized OATPs.
Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake.
Neuvonen et al., Helsinki, Finland. In Pharmacol Rev, 2011
OATP1B1, current knowledge: expression, function, substrate characteristics, pharmacogenetics, and role in drug interactions [REVIEW]
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
Relling et al., Memphis, United States. In J Clin Oncol, 2010
Germline genetic variation in SLCO1B1 is associated with methotrexate pharmacokinetics and clinical effects.
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