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Nuclear RNA export factor 3

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NXF2, C-1, p15, NXF5, CAN
Papers on NXF3
Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome.
Wang et al., Philadelphia, United States. In Hum Mol Genet, 2014
Male mice with a deletion of a 1.1 Mb Nxf2-Nxf3 X-chromosomal segment exhibit respiratory failure, neonatal lethality and cleft palate.
Prognostic significance of nuclear RNA export factor 3 in hepatocellular carcinoma.
Huang et al., Shanghai, China. In Oncol Lett, 2014
Nuclear RNA export factor 3 (NXF3) is a member of the nuclear RNA export factor family that plays a role in mediating the export of cellular mRNA from the nucleus to the cytoplasm for translation.
An X-chromosomal association study identifies a susceptibility locus at Xq22.1 for hepatitis B virus-related hepatocellular carcinoma.
Huang et al., Shanghai, China. In Clin Res Hepatol Gastroenterol, 2013
The expressions of the three genes near the rs5945919 locus, RAB40AL, BEX1, and NXF3, were analyzed by qRT-PCR between another 24 HCC tissues and paired peritumoral liver tissues.
A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.
Wang et al., Philadelphia, United States. In Biol Reprod, 2013
Here we report the deletion of a 1.1-Mb segment of the mouse X chromosome that is syntenic with the human Xq22.1 region and contains 20 genes that are expressed predominantly in testis and brain, including three members of the nuclear export factor gene family (Nxf2, Nxf3, and Nxf7) and five copies of preferentially expressed antigen in melanoma-like 3 (Pramel3).
Nuclear export factor 3 is involved in regulating the expression of TGF-β3 in an mRNA export activity-independent manner in mouse Sertoli cells.
Sun et al., Hefei, China. In Biochem J, 2013
However, little is known about the roles of NXF3 in spermatogenesis.
De novo duplication of Xq22.1→q24 with a disruption of the NXF gene cluster in a mentally retarded woman with short stature and premature ovarian failure.
Wang et al., Taipei, Taiwan. In Taiwan J Obstet Gynecol, 2011
RESULTS: The duplicated region contained NXF2B, NXF4, NXF3, PLP1, and PGRMC1 genes.
Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis.
Wang et al., Philadelphia, United States. In Mol Reprod Dev, 2011
The Nxf3 is expressed exclusively in Sertoli cells of the postnatal testis, in a developmentally regulated manner.
Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.
Wang et al., Philadelphia, United States. In Dev Biol, 2009
In mouse, four Nxf genes have been identified: Nxf1, Nxf2, Nxf3, and Nxf7.
NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins.
Yoneda et al., Suita, Japan. In Nucleic Acids Res, 2006
In mice, three additional NXF family genes (NXF2, NXF3, NXF7) have been identified and characterized to date.
Molecular cloning and functional characterization of mouse Nxf family gene products.
Yoneda et al., Suita, Japan. In Genomics, 2005
cDNAs encoding the mouse NXF proteins (Tap, NXF7, NXF2, and NXF3) were prepared and the gene products were characterized in terms of their genomic organization, expression patterns, and biochemical properties.
NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila.
Izaurralde et al., Heidelberg, Germany. In Rna, 2001
Depleting endogenous NXF2 or NXF3 has no apparent phenotype.
NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation.
Froyen et al., Leuven, Belgium. In Curr Biol, 2001
Molecular analysis of both breakpoint regions did not reveal an interrupted gene on Xp, but identified a novel nuclear RNA export factor (NXF) gene cluster, Xcen-NXF5-NXF2-NXF4-NXF3-Xqter, in which NXF5 is split by the breakpoint, leading to its functional nullisomy.
Two closely related human nuclear export factors utilize entirely distinct export pathways.
Cullen et al., Durham, United States. In Mol Cell, 2001
Here we demonstrate that NXF3, a human RNA binding protein related to TAP, lacks this domain yet retains the ability to export tethered RNA transcripts and to shuttle between the nucleus and the cytoplasm.
TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.
Izaurralde et al., Heidelberg, Germany. In Mol Cell Biol, 2000
NXF3, which does not bind RNA or localize to the nuclear rim, has no RNA export activity.
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