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Nuclear RNA export factor 2

NXF2, CT39
This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NXF3, CAN, NXF5, C-1, MEN
Papers on NXF2
Molecular characterization of human Torque Teno virus.
Li et al., Nanchang, China. In Biomed Rep, Nov 2015
In addition, nest-PCR was used to detect TTV within different phylogenetic groups among the 64 specimens, and the results showed that groups 1 (TA278 strain), 4 (KC009) and 5 (CT39) were much more prevalent than groups 2 (PMV isolate) and 3 (11 genotypes) in the different departmental patients.
Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome.
Wang et al., Philadelphia, United States. In Hum Mol Genet, 2014
Male mice with a deletion of a 1.1 Mb Nxf2-Nxf3 X-chromosomal segment exhibit respiratory failure, neonatal lethality and cleft palate.
Cancer-testis antigen expression in digestive tract carcinomas: frequent expression in esophageal squamous cell carcinoma and its precursor lesions.
Yantiss et al., New York City, United States. In Cancer Immunol Res, 2014
The highest frequency of expression was found in esophageal squamous cell carcinomas: Positive staining for MAGEA, CT45, CT7, SAGE1, GAGE, NXF2, NY-ESO-1, and CT10 was observed in 57%, 38%, 33%, 33%, 29%, 29%, 19%, and 14% of squamous cell carcinomas, respectively.
The cancer‑testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo.
Yu et al., Beijing, China. In Mol Med Report, 2013
Nuclear RNA export factor 2 (NXF2) is a CTA of which the expression pattern, regulation and clinical significance are unclear.
Expression of cancer/testis (CT) antigens in squamous cell carcinoma of the head and neck: evaluation as markers of squamous dysplasia.
Chen et al., New York City, United States. In Pathol Res Pract, 2013
The expression of 8 CT antigens (MAGE-A, GAGE, NY-ESO-1, CT7, CT10, SAGE1, CT45 and NXF2) in 76 cases of invasive head and neck squamous cell carcinoma (SCC) was evaluated immunohistochemically.
A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.
Wang et al., Philadelphia, United States. In Biol Reprod, 2013
Here we report the deletion of a 1.1-Mb segment of the mouse X chromosome that is syntenic with the human Xq22.1 region and contains 20 genes that are expressed predominantly in testis and brain, including three members of the nuclear export factor gene family (Nxf2, Nxf3, and Nxf7) and five copies of preferentially expressed antigen in melanoma-like 3 (Pramel3).
Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability.
Froyen et al., Leuven, Belgium. In Plos One, 2012
Based on synteny, mouse Nxf2 is the ortholog of human NXF5.
Multiple cancer testis antigens function to support tumor cell mitotic fidelity.
Whitehurst et al., Chapel Hill, United States. In Mol Cell Biol, 2012
Remarkably, these testis proteins, FMR1NB, NXF2, MAGEA5, FSIP1, and STARD6, are required for accurate chromosome segregation in tumor cells.
The kinesin superfamily protein KIF17: one protein with many functions.
Besharse et al., Milwaukee, United States. In Biomol Concepts, 2012
KIF17's interaction with NXF2 enables the transport of mRNA bidirectionally in dendrites.
The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.
Williamson et al., Los Angeles, United States. In J Mol Biol, 2012
NXF1-like members of the NXF (nuclear export factor) family orchestrate bulk nuclear export of mRNA, while functionally distinct NXF variant proteins carry out separate substrate-specific and tissue-specific RNA regulation.
[Sex chromosomes and male infertility].
Huang et al., Nanjing, China. In Zhonghua Nan Ke Xue, 2010
The importance of the X chromosome in mammalian spermatogenesis is suggested by its enrichment of germ cell-specific genes expressed in spermatogenesis, such as AR, USP26, TAF7L, TEX11, KAL1, AKAP4, and NXF2.
Regulation of male fertility by X-linked genes.
Wang et al., Philadelphia, United States. In J Androl, 2010
Recent genetic studies in mice show that X-linked, germ cell-specific genes, such as A-kinase anchor protein 4 (Akap4), nuclear RNA export factor 2 (Nxf2), TBP-associated factor 7l (Taf7l), and testis-expressed gene 11 (Tex11), indeed play important roles in the regulation of male fertility.
Male infertility and the involvement of the X chromosome.
Lissens et al., Brussels, Belgium. In Hum Reprod Update, 2009
In the second part of the study, the results of mutation analyses of seven genes (AR, SOX3, USP26, NXF2, TAF7L, FATE and AKAP4) are described.
Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.
Wang et al., Philadelphia, United States. In Dev Biol, 2009
These studies demonstrate that Nxf2 plays a dual function in spermatogenesis: regulation of meiosis and maintenance of spermatogonial stem cells.
[Genetics and male infertility].
Lissens et al., Brussels, Belgium. In Verh K Acad Geneeskd Belg, 2008
The genes NXF2, USP26 and TAF7L were investigated for the presence of mutations.
Is there a role for the nuclear export factor 2 gene in male infertility?
Lissens et al., Brussels, Belgium. In Fertil Steril, 2008
Data do not support role for NXF2 in male infertility.
Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells.
Huang et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2007
FMRP and Nxf2 associate with and destabilize Nxf1 mRNA in neuronal cells.
NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins.
Yoneda et al., Suita, Japan. In Nucleic Acids Res, 2006
Results suggest that NXF2, a nucleo-cytoplasmic mRNA transporter, plays additional roles in the cytoplasmic localization of mRNAs through interactions with cytoplasmic motor proteins.
The role of spermatogonially expressed germ cell-specific genes in mammalian meiosis.
Pan et al., Philadelphia, United States. In Chromosome Res, 2006
In particular, we cite previously unpublished studies demonstrating that the NXF2 protein, an X-encoded factor, is present in early spermatocytes.
Identification and characterization of the mouse nuclear export factor (Nxf) family members.
Felber et al., Frederick, United States. In Nucleic Acids Res, 2004
The NXF2 protein is found in the nucleus, the nuclear envelope and cytoplasm, and is an active mRNA export receptor.
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