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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

NudE nuclear distribution gene E homolog

Nudel, NDEL1, EOPA
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: 1-Alkyl-2-acetylglycerophosphocholine Esterase, DISC1, V1a, CAN, NdeI
Papers using Nudel antibodies
NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
Vallee Richard B. et al., In The Journal of Cell Biology, 2002
... Full-length NudE and NudEL as well as the NudE-C188 and NudE-N189 deletion constructs were each cloned from a mouse cDNA library using the Marathon cDNA Amplification kit (CLONTECH Laboratories, Inc.) into pEGFP-C1 ...
Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation
Hirotsune Shinji et al., In The Journal of Cell Biology, 2001
... Ndel1 cDNA was conjugated to pLexA (Clontech Laboratories, Inc.) and used ...
Papers on Nudel
Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis.
Belangero et al., São Paulo, Brazil. In Eur Neuropsychopharmacol, Dec 2015
We observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls.
Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis.
Maes et al., São Paulo, Brazil. In Mol Neurobiol, Nov 2015
FEP patients with depression showed increased COMT expression and decreased NDEL1 expression.
Half-life of DISC1 protein and its pathological significance under hypoxia stress.
Kamiya et al., Baltimore, United States. In Neurosci Res, Aug 2015
Overexpression of PDE4B2, a binding partner of DISC1, prolonged the half-life of DISC1, whereas NDEL1 does not alter DISC1 protein stability.
The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system.
Collinson et al., Aberdeen, United Kingdom. In Neuroscience, 2014
While genetic linkage analyses have shown an association of nuclear distribution factor E (NDE1, or NudE) and its ohnolog NDE-like 1 (NDEL1, or Nudel) with mental disorders, the cellular mechanisms remain unclear.
Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia.
Evans et al., Edinburgh, United Kingdom. In Plos One, 2013
Finally, the expression levels of DISC1, AKAP9, FEZ1, NDEL1 and PCM1 were compared between 63 controls and 69 schizophrenic subjects.
Molecular pathways controlling the sequential steps of cortical projection neuron migration.
Hippenmeyer, Klosterneuburg, Austria. In Adv Exp Med Biol, 2013
In this chapter, I will focally review recent advances that improved our understanding of the cell-autonomous and possible cell-nonautonomous functions of the evolutionarily conserved LIS1/NDEL1-complex in regulating the sequential steps of cortical projection neuron migration.
NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.
Soares et al., Düsseldorf, Germany. In Biomol Concepts, 2013
Nuclear distribution element 1 (NDE1, also known as NudE) and NDE-like 1 (NDEL1, also known as Nudel) are paralogous proteins essential for mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders.
A unique role of dynein and nud family proteins in corticogenesis.
Hirotsune et al., Ōsaka, Japan. In Neuropathology, 2012
In particular, we reported that LIS1 and NDEL1 are essential for dynein transport to the plus-end of microtubules by kinesin, which is essential to maintain the proper distribution of cytoplasmic dynein within the cell.
Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance.
Zhu et al., Shanghai, China. In Cell Res, 2012
Cytosolic mfGbeta is recruited to dynein by Nudel and transported to the centrosome for rapid sequestration and degradation.
Multiple modes of cytoplasmic dynein regulation.
Ori-McKenney et al., New York City, United States. In Nat Cell Biol, 2012
Studies indicate that binding of dynactin, LIS1 and NudEL regulate cytoplasmic dynein motor activity.
DISC1-binding proteins in neural development, signalling and schizophrenia.
Porteous et al., Edinburgh, United Kingdom. In Neuropharmacology, 2012
APP, Dixdc1, LIS1, NDE1, NDEL1), neural progenitor proliferation (GSK3β), neurosignalling (Girdin, GSK3β, PDE4) and synaptic function (Kal7, TNIK).
Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly.
Wagner et al., Boston, United States. In J Biol Chem, 2012
DISC1 forms octamers via dimers as building blocks. S704C forms higher-order oligomers, without affecting its affinity with NDEL1
A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.
Smith et al., Columbia, United States. In J Neurosci, 2011
Expressing a mutant Ndel1 lacking key phosphorylation sites shuts down organelle transport completely in axons.
Ndel1, Nudel (Noodle): flexible in the cell?
Nguyen et al., Calgary, Canada. In Cytoskeleton (hoboken), 2011
Nuclear distribution element-like 1 (Ndel1 or Nudel) was firstly described as a regulator of the cytoskeleton in microtubule and intermediate filament dynamics and microtubule-based transport.
LIS1 and NudE induce a persistent dynein force-producing state.
Gross et al., New York City, United States. In Cell, 2010
LIS1, NudE, and NudEL are dynein interactors initially implicated in brain developmental disease but now known to be required in cell migration, nuclear, centrosomal, and microtubule transport, mitosis, and growth cone motility.
An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics.
Hirotsune et al., Ōsaka, Japan. In Nat Cell Biol, 2009
These findings demonstrate a surprising role of aPKC-Aurora A-NDEL1 pathway in microtubule remodelling during neurite extension.
Aurora A moonlights in neurite extension.
Gleeson et al., In Nat Cell Biol, 2009
PKCzeta activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension.
Requirement for Nudel and dynein for assembly of the lamin B spindle matrix.
Zheng et al., Shanghai, China. In Nat Cell Biol, 2009
Nudel regulates microtubule organization in part by facilitating assembly of the lamin B spindle matrix in a dynein-dependent manner.
Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division.
Wynshaw-Boris et al., Los Angeles, United States. In Cell, 2008
Increased expression of the LIS/dynein binding partner NDEL1 restores cortical microtubule and dynein localization in Lis1-deficient cells.
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