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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Nucling, UACA, betacap73, Uveal autoantigen with coiled coil domains and ankyrin repeats
Top mentioned proteins: PrP, Autoantigen, CAN, Apaf-1, V1a
Papers on Nucling
Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3.
Fukui et al., Tokushima, Japan. In J Biol Chem, Nov 2015
We herein identified Nucling as an important regulator of involution of the mammary gland.
Identification of UACA, EXOSC9, and ΤΜX2 in bovine periosteal cells by mass spectrometry and immunohistochemistry.
Akiyama, Hirakata, Japan. In Anal Bioanal Chem, 2014
Mass spectrometry analysis of partial peptide data combined with immunohistochemistry also indicated that uveal autoantigen with coiled coil domains and ankyrin repeats (UACA), exosome complex component RRP45 (EXOSC9), and thioredoxin-related transmembrane protein 2 (TMX2) were expressed in bovine periosteal cells.
Identification of novel binding partners for caspase-6 using a proteomic approach.
Park et al., Kongju, South Korea. In J Microbiol Biotechnol, 2014
Of these, five proteins (hnRNP-M, DHX38, ASPP2, MTA2, and UACA) were subsequently examined by co-immunoprecipitation for interactions with caspase-6.
Paracrine apoptotic effect of p53 mediated by tumor suppressor Par-4.
Rangnekar et al., Lexington, United States. In Cell Rep, 2014
Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4.
Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells.
Fukuda et al., Sendai, Japan. In Biochem Biophys Res Commun, 2013
We screened for a Rab39-specific effector by performing a yeast two-hybrid assay with GTP-locked Rab39A/B as the bait and identified UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) as a specific Rab39A/B-binding protein.
Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4.
Rangnekar et al., Lexington, United States. In Cancer Res, 2013
Mechanistic investigations revealed that NF-κB mediated this antiapoptotic mechanism by upregulating expression of UACA, a proinflammatory protein in certain disease settings.
Nucling, a novel protein associated with NF-κB, regulates endotoxin-induced apoptosis in vivo.
Fukui et al., Tokushima, Japan. In J Biochem, 2013
Nucling is a proapoptotic protein that regulates the apoptosome and nuclear factor-kappa B (NF-κB) signalling pathways.
Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.
Kainov et al., Helsinki, Finland. In Cell Death Dis, 2012
In particular, we demonstrate that ABT-263 altered Bcl-xL interactions with Bcl-2 antagonist of cell death (Bad), Bcl-2-associated X protein (Bax), uveal autoantigen with coiled-coil domains and ankyrin repeats protein (UACA).
Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo.
D'Cunha et al., Minneapolis, United States. In Plos One, 2012
Expression of pro-survival and anti-apoptotic genes (HSP70, BIRC5, BIRC4, BIRC2, UACA, APAF-1) was estimated by qRTPCR.
Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma.
Benkova et al., Praha, Czech Republic. In Int J Oncol, 2012
The down-regulation of APIP and UACA expression suggests that the threshold to activate the apoptosome apparatus may be decreased in non-small cell lung cancer cells.
The role of Kupffer cells in carbon tetrachloride intoxication in mice.
Kojo et al., Nara, Japan. In Biol Pharm Bull, 2011
We investigated the role of Kupffer cells during CCl(4) intoxication using Nucling-knockout mice (the KO group), in which the number of Kupffer cells is largely reduced.
NF-kappaB regulates the expression of Nucling, a novel apoptosis regulator, with involvement of proteasome and caspase for its degradation.
Fukui et al., Tokushima, Japan. In J Biochem, 2010
Nucling expression is induced by canonical NF-kappaB signalling pathway, whereas Nucling is undergoing proteasome degradation, as well as being cleaved by caspase system under stress conditions
Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice.
Fukui et al., Tokushima, Japan. In Int J Cancer, 2010
Nucling deficiency could be a powerful tool to reveal the NF-kappaB-related molecular networks leading to hepatitis and hepatocellular carcinoma development.
Inhibition of angiogenesis in vitro: a central role for beta-actin dependent cytoskeletal remodeling.
Herman et al., Boston, United States. In Microvasc Res, 2009
Specifically, the beta-actin network has previously been shown to be (i) enriched in regions of highly motile cytoplasm, and (ii) modulated by its isoactin-specific barbed-end capping protein, beta cap73.
Nucling interacts with nuclear factor-kappaB, regulating its cellular distribution.
Fukui et al., Tokushima, Japan. In Febs J, 2009
a novel function of Nucling as a suppressor of nuclear factor-kappaB, mediated by its cytoplasmic retention through physical interaction
Attenuation of MPTP-induced neurotoxicity and locomotor dysfunction in Nucling-deficient mice via suppression of the apoptosome pathway.
Fukui et al., Tokushima, Japan. In J Neurochem, 2006
These results indicate an important role for Nucling in MPTP-induced neuronal degeneration and suggest that the suppression of Nucling would be of therapeutic benefit for the treatment of neurodegeneration in PD.
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